10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1, MLL-1). More than 80 fusion partners have been identified, and differences in fusion partner have been linked t...

The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.

Nature Metabolism, Published online: 16 September 2025; doi:10.1038/s42255-025-01352-4Rizzollo et al. show that BDH2 participates in iron distribution between cellular compartments, which sets the threshold for the ferroptosis vulnerability of the melanoma cell phenotypes, ultimately affecting their metastatic capacity

Metabolomic profiling of chemoresistant AML shows branched-chain amino acid accumulation that fuels protein translation. Mayerhofer et al. identify the ribosomal hydroxylase OGFOD1 as a regulator of this BCAA-dependent protein synthesis program, linking its activity to post-chemotherapy relapse.