Abstract. Nocardiosis is an uncommon yet potentially devastating infection. Nocardia tends to affect individuals with chronic lung disease or immunocomprom

Sorbonne Université met à disposition un dispositif d’accompagnement pour renforcer les projets Marie Skłodowska Curie Postdoctoral Fellowships.

AbstractNocardiosis is an uncommon yet potentially devastating infection. Nocardia tends to affect individuals with chronic lung disease or immunocompromising conditions, 2 groups increasing in number. Incidence of nocardiosis is likely to increase as well, and it is vital to have an approach to this complex disease. Here, we aim to review the presentation, diagnosis, and management of Nocardia in the modern era. We will also highlight areas of uncertainty in our understanding of nocardiosis and propose a general approach to nocardiosis therapy, accounting for response and tolerance of Nocardia treatment.

Prompt and accurate diagnosis of Nocardia skin infections is important in immunocompromised hosts, especially transplant patients. The sporotrichoid form, which is otherwise known as the lymphocutaneo...

ISBA2025

The northern snakehead (<i>Channa argus</i>) is a valuable aquaculture species across certain Asian countries, contributing significantly to economic prosperity and dietary needs. However, its productivity faces significant challenges, particularly from diseases such as nocardiosis, caused by <i>Noc</i> …

Purpose The prolonged treatment recommended for nocardiosis does not rely on strong evidence. Consequently, some clinicians opt shorter therapy in certain circumstances. We assessed the effectiveness ...

A combined strategy of 2D-NMR-metabolomics-driven substructure tracking with genome mining led to the targeted discovery of 10 nocobactin-type lipopeptides (1–10) from the Arctic-derived phychrophillic Nocardia sp. L-016, among which 1–5 are new compounds, named nocardimicins S–W. The phenoxazole moiety in 1–10, featuring unique NMR values and correlations, was used as a probe for tracking nocardimicin analogues. The structures of 1–5 were established based on extensive MS and NMR spectroscopic analyses. The biosynthesis of nocardimicins (1–10) in Nocardia sp. L-016 is proposed to be achieved by the noc biosynthetic gene cluster, which is composed of two sub-gene clusters (I and II) separated by a 228 kb region. Compounds 1–10 showed moderate inhibition against human cancer cell lines of HCT116 and HepG2 with IC50 values in the range of 3.5–10.2 μM. This work provides an effective application of paired-omics technologies in the discovery of new natural products.

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Brasilicardin A, BraA, is a secondary metabolite produced by the bacterium Nocardia terpenica, and a

Brasilicardin A, BraA, is a secondary metabolite produced by the bacterium Nocardia terpenica, and a

Soil-dwelling Actinomycetes are a diverse and ubiquitous component of the global microbiome, but lar

Nocardia are gram-positive bacteria from the actinobacterial class. Some Nocardia species can infect

Nocardia are gram-positive bacteria from the actinobacterial class. Some Nocardia species can infect