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Olivier Saulnier @olivier-saulnier.bsky.social · 28d

RNA-binding proteins mediate the maturation of chromatin topology during differentiation

www.nature.com/articles/s41...

RNA-binding proteins mediate the maturation of chromatin topology during differentiation - Nature Cell Biology

Dehingia, Milewska-Puchała and colleagues find a pervasive lncRNA-mediated increase in interactions between CTCF and RNA-binding proteins during embryonic stem cell differentiation. These interactions...

www.nature.com

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Olivier Saulnier @olivier-saulnier.bsky.social · Sep 4

Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do
www.cell.com/neuron/fullt...

Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do

In this comprehensive review, Karreman & Winkler explore how neural influences on the brain’s metastatic process govern brain tropism, colonization, and growth. Conversely, metastatic cancer has disti...

www.cell.com

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Olivier Saulnier @olivier-saulnier.bsky.social · Sep 4

Cell-type-specific enrichment of somatic aneuploidy in the mammalian brain

www.cell.com/neuron/fullt...

Cell-type-specific enrichment of somatic aneuploidy in the mammalian brain

Mutations during brain development can alter the DNA of neurons, impacting their genetic identity. Using single-nucleus DNA methylation sequencing data from the adult mouse brain, Mukamel et al. ident...

www.cell.com

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Olivier Saulnier @olivier-saulnier.bsky.social · Aug 28

Kinda philosophical — depends if you separate cell types from cell states. Most “types” probably go through transient states at some point (this is actually hard to pinpoint), so the total number can blow up

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Olivier Saulnier @olivier-saulnier.bsky.social · Aug 28

www.biorxiv.org/content/10.1...
SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms

SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms

The alternative splicing of the adapter protein NUMB is dysregulated in multiple cancer types, regulating its functional divergence towards either tumor suppression or oncogenesis in an isoform depend...

www.biorxiv.org

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Olivier Saulnier @olivier-saulnier.bsky.social · Jul 10

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice
www.nature.com/articles/s41...

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience

Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...

www.nature.com

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Olivier Saulnier @olivier-saulnier.bsky.social · Jul 3

Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants

www.nature.com/articles/s41...

Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants - Nature Biotechnology

The effects of oncofusions and other protein variants on chromatin remodeling are identified by PROD-ATAC.

www.nature.com

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Olivier Saulnier @olivier-saulnier.bsky.social · Jul 1

Gene context drift identifies drug targets to mitigate cancer treatment resistance
www.cell.com/cancer-cell/...

Gene context drift identifies drug targets to mitigate cancer treatment resistance

Jassim et al. introduce a graph-embedding computational pipeline (RECODR) that measures changes in gene co-expression context during cancer treatment. RECODR enables the design of highly effective com...

www.cell.com

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Olivier Saulnier @olivier-saulnier.bsky.social · Jun 13

Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis

www.biorxiv.org/content/10.1...

Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis

The transition from benign to malignant growth is a pivotal yet poorly understood step in cancer progression that marks the shift from a pathologically inert condition to a clinically lethal disease. ...

www.biorxiv.org

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Olivier Saulnier @olivier-saulnier.bsky.social · Jun 10

It was great to see you ☀️

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Olivier Saulnier @olivier-saulnier.bsky.social · May 20

Congratulations @cedricboeckx.bsky.social 🎉, looking forward to reading it!!

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Reposted by Olivier Saulnier

Silvia De Rubeis @derubeislab.bsky.social · May 18

🧪 New paper alert!

In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠

www.nature.com/articles/s41...

Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X - Nature Communications

Genetic mutations in the DDX3X gene are associated with a neurodevelopmental disorder primarily affecting females. Here authors show that Ddx3x mediates sexual dimorphisms during brain development at ...

www.nature.com

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Olivier Saulnier @olivier-saulnier.bsky.social · May 19

Radiation-induced amphiregulin drives tumour metastasis
doi.org/10.1038/s415...

Radiation-induced amphiregulin drives tumour metastasis - Nature

Radiotherapy induces expression of the EGFR ligand amphiregulin, which promotes metastasis growth at remote sites in mouse models and human patients by shifting myeloid cells towards an immunosup...

doi.org

Reposted by Olivier Saulnier

Debby Silver @debbysilver.bsky.social · May 14

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

www.nature.com

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Reposted by Olivier Saulnier

Transposon and Cancer Epigenetics Group @deniz-lab.bsky.social · May 6

I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...

Transposable elements as genome regulators in normal and malignant haematopoiesis - Blood Cancer Journal

Blood Cancer Journal - Transposable elements as genome regulators in normal and malignant haematopoiesis

www.nature.com

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Reposted by Olivier Saulnier

Institut Curie @institutcurie.bsky.social · May 6

📆 5-6 juin 2025 : Paris Kids Cancer, co-dirigé par l’ @ap-hp.bsky.social , @gustaveroussy.fr, l’Institut National du Cancer et l’Institut Curie, organise son 1er symposium sur le système immunitaire chez l'enfant et sa dysrégulation
ℹ️ plus d'information : curie.fr/symposium-paris-kids-cancer-2025

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Olivier Saulnier @olivier-saulnier.bsky.social · May 6

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure
www.cell.com/cell-reports...

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure

LaBelle et al. show immune microenvironment changes following chemo-/radiotherapy and immune checkpoint blockade therapy via single-cell RNA-seq of matched tumor, T cells, and myeloid cells in pediatr...

www.cell.com

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Reposted by Olivier Saulnier

Victor Javier @vjsanchez.bsky.social · Apr 25

Spatial mapping of transcriptomic plasticity in metastatic #PancreaticCancer 🧪 www.nature.com/articles/s41...

Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer - Nature

Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation i...

www.nature.com

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Olivier Saulnier @olivier-saulnier.bsky.social · Apr 24

Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth

www.nature.com/articles/s41...

Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth - Nature Cell Biology

Abeysundara, Rasnitsyn, Fong et al. report that the presence of leptomeningeal metastatic tumour cells leads to the recruitment and remodelling of fibroblasts, which, in turn, facilitate the colonizat...

www.nature.com

Olivier Saulnier @olivier-saulnier.bsky.social · Apr 23

Happy to add you @r-rahbari.bsky.social

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Olivier Saulnier @olivier-saulnier.bsky.social · Apr 22

Congratulations @haldipur.bsky.social, It's great to see it out! 🧠
Mapping the developmental profile of ventricular zone-derived neurons in the human cerebellum
doi.org/10.1073/pnas...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

doi.org

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Reposted by Olivier Saulnier

Evgeny Kvon @evgenykvon.bsky.social · Apr 9

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...

DNA-guided transcription factor interactions extend human gene regulatory code - Nature

A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

www.nature.com

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Reposted by Olivier Saulnier

Institut Curie @institutcurie.bsky.social · Apr 8

🔴 Dans un entretien à @lexpress.bsky.social, Yasmine Belkaid DG @pasteur.fr, Bana Jabri DG @institutimagine.bsky.social et Alain Puisieux, Pdt du Directoire de l’Institut Curie, lancent un appel pour défendre la #science face aux menaces qui pèsent sur elle.

➡️ www.lexpress.fr/sciences-san...

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Olivier Saulnier @olivier-saulnier.bsky.social · Apr 8

The path to leptomeningeal metastasis
www.nature.com/articles/s41...

The path to leptomeningeal metastasis - Nature Reviews Cancer

Metastasis to the leptomeninges causes substantial neurological morbidity and mortality. Owing to the lack of mechanistic studies in this area, patients still face a bleak clinical prognosis. In this ...

www.nature.com

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Reposted by Olivier Saulnier

Nori Zolboot @norjin.bsky.social · Apr 2

✨So happy to see part of my PhD work with @lippilab.bsky.social out today in @cp-neuron.bsky.social! ✨

We developed new tools to study microRNA-target networks with greater spatial and temporal resolution and found neuronal subtype- and developmental stage-specific roles:

MicroRNA mechanisms instructing Purkinje cell specification

Zolboot et al. introduce DD-T6B and SAP-seq, methods for investigating microRNA function with enhanced spatiotemporal resolution, and identify Purkinje cell-specific microRNAs and targets instructing ...

www.cell.com

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