Omar Kamileen
@omarkamileen.bsky.social
An impatient optimist. 🇩🇪🇱🇰
Reposted by Omar Kamileen
Mass spectrometry imaging: principles and applications in plant research nph.onlinelibrary.wiley.com/doi/10.1111/... @newphyt.bsky.social
Mass spectrometry imaging: principles and applications in plant research
Mass spectrometry imaging (MSI) is an advanced analytical technique that combines mass spectrometry with spatial mapping, enabling the direct, label-free detection and visualization of molecular dist...
nph.onlinelibrary.wiley.com
December 26, 2025 at 10:21 PM
Mass spectrometry imaging: principles and applications in plant research nph.onlinelibrary.wiley.com/doi/10.1111/... @newphyt.bsky.social
Reposted by Omar Kamileen
Dopamine biosynthesis in plants https://www.biorxiv.org/content/10.64898/2025.12.10.693491v1
December 14, 2025 at 1:02 AM
Dopamine biosynthesis in plants https://www.biorxiv.org/content/10.64898/2025.12.10.693491v1
Reposted by Omar Kamileen
Nicotine biosynthesis completed by cryptic activating glucosylation https://www.biorxiv.org/content/10.64898/2025.12.04.692101v1
December 7, 2025 at 1:45 AM
Nicotine biosynthesis completed by cryptic activating glucosylation https://www.biorxiv.org/content/10.64898/2025.12.04.692101v1
Reposted by Omar Kamileen
🔓Don't miss in our latest issue this #OpenAccess review by @maximilianfrey.bsky.social & co. @ipbhalle.bsky.social, @unihalle.bsky.social & @mpi-ce.bsky.social looking at the biosynthesis of biologically active terpenoids in the mint family #naturalproducts #secmet
Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)
Covering: 2000 to 2025 The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including…
pubs.rsc.org
December 4, 2025 at 12:52 PM
🔓Don't miss in our latest issue this #OpenAccess review by @maximilianfrey.bsky.social & co. @ipbhalle.bsky.social, @unihalle.bsky.social & @mpi-ce.bsky.social looking at the biosynthesis of biologically active terpenoids in the mint family #naturalproducts #secmet
Reposted by Omar Kamileen
#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
November 24, 2025 at 4:57 PM
#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
Reposted by Omar Kamileen
Researchers have manufactured organic light-emitting diodes (OLED) on a nanoscale – that’s around a hundred times smaller than a human cell. This not only enables ultra-sharp screens and microscopes, but also opens up entirely novel possibilities for wave optics applications. ethz.ch/en/news-and-...
Manufacturing the world's tiniest light-emitting diodes
Researchers from ETH Zurich have manufactured organic light-emitting diodes (OLEDs) on a nanoscale – that’s around a hundred times smaller than a human cell. This not only enables ultra-sharp screens ...
ethz.ch
November 24, 2025 at 9:40 AM
Researchers have manufactured organic light-emitting diodes (OLED) on a nanoscale – that’s around a hundred times smaller than a human cell. This not only enables ultra-sharp screens and microscopes, but also opens up entirely novel possibilities for wave optics applications. ethz.ch/en/news-and-...
Reposted by Omar Kamileen
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 21, 2025 at 5:37 PM
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
Reposted by Omar Kamileen
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
www.science.org
November 21, 2025 at 10:20 AM
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
Reposted by Omar Kamileen
Multimodal learning enables chat-based exploration of single-cell data - @bocklab.bsky.social @cemm.oeaw.ac.at @meduniwien.ac.at go.nature.com/3WPGJnW
Multimodal learning enables chat-based exploration of single-cell data - Nature Biotechnology
CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.
go.nature.com
November 11, 2025 at 4:58 PM
Multimodal learning enables chat-based exploration of single-cell data - @bocklab.bsky.social @cemm.oeaw.ac.at @meduniwien.ac.at go.nature.com/3WPGJnW
Reposted by Omar Kamileen
Tension, suspense, or narrative arc in a story is the stuff that keeps the reader going. But how do you introduce suspense in a scientific article? That is what my latest post is all about.
aboutacademicwritingandzo.substack.com/p/how-to-wri...
#AcademicWriting #WritingTips #NarrativeArc #Suspense
aboutacademicwritingandzo.substack.com/p/how-to-wri...
#AcademicWriting #WritingTips #NarrativeArc #Suspense
How to write your paper like a page turner
Working my way through scientific articles I often lose my focus.
aboutacademicwritingandzo.substack.com
November 6, 2025 at 1:22 PM
Tension, suspense, or narrative arc in a story is the stuff that keeps the reader going. But how do you introduce suspense in a scientific article? That is what my latest post is all about.
aboutacademicwritingandzo.substack.com/p/how-to-wri...
#AcademicWriting #WritingTips #NarrativeArc #Suspense
aboutacademicwritingandzo.substack.com/p/how-to-wri...
#AcademicWriting #WritingTips #NarrativeArc #Suspense
www.nature.com/articles/s41... Really fabulous work! Animal pigments engineered in bacteria.
Growth-coupled microbial biosynthesis of the animal pigment xanthommatin - Nature Biotechnology
A growth-coupled biosynthetic pathway enables xathommatin synthesis in the soil bacterium Pseudomonas putida.
www.nature.com
November 3, 2025 at 10:09 PM
www.nature.com/articles/s41... Really fabulous work! Animal pigments engineered in bacteria.
Reposted by Omar Kamileen
Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants go.nature.com/3CdewQS
rdcu.be/eNaje
rdcu.be/eNaje
Binary vector copy number engineering improves Agrobacterium-mediated transformation - Nature Biotechnology
Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants.
go.nature.com
October 31, 2025 at 3:04 AM
Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants go.nature.com/3CdewQS
rdcu.be/eNaje
rdcu.be/eNaje
Reposted by Omar Kamileen
Excited to see our paper online! We combined scMS and scRNA-seq from the same plant cells 🌱 — a step toward true single-cell multi-omics in plants.
Overview 👇
Overview 👇
A research team from the @oconnorlab.bsky.social has made a breakthrough in elucidating the biosynthesis of plant natural products by combining scRNA-seq and scMS in the same plant cell. The study was published in @pnas.org. www.ice.mpg.de/516369/PR_Ka...
A glimpse into the cell factory: matching gene expression to metabolite production in single plant cells
A research team at the Max Planck Institute for Chemical Ecology has successfully combined single-cell RNA sequencing (scRNA-seq) and single-cell mass spectrometry (scMS) analysis on the same plant ce...
www.ice.mpg.de
October 27, 2025 at 6:32 PM
Excited to see our paper online! We combined scMS and scRNA-seq from the same plant cells 🌱 — a step toward true single-cell multi-omics in plants.
Overview 👇
Overview 👇
Reposted by Omar Kamileen
Discovery and engineering of the biosynthesis of rotenoids www.nature.com/articles/s44... @natsynth.nature.com
Discovery and engineering of the biosynthesis of rotenoids - Nature Synthesis
Rotenoids are natural insecticides from Fabaceae plants. Here the complete biosynthetic pathway to make rotenoids is elucidated in Amorpha fruticosa and Tephrosia vogelii, revealing a unique Fe(II)-de...
www.nature.com
October 21, 2025 at 8:41 PM
Discovery and engineering of the biosynthesis of rotenoids www.nature.com/articles/s44... @natsynth.nature.com
Reposted by Omar Kamileen
Very exciting to finally see our iridoid cyclase ICYC online @natplants.nature.com!
A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
Discovery of iridoid cyclase completes the iridoid pathway in asterids - Nature Plants
Iridoids are terpenoid metabolites found in thousands of plants. Using single-cell transcriptomics, the authors discovered an unexpected enzyme that has been neofunctionalized to catalyse the cyclization required to form the iridoid scaffold.
www.nature.com
October 3, 2025 at 9:39 AM
Very exciting to finally see our iridoid cyclase ICYC online @natplants.nature.com!
A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
Reposted by Omar Kamileen
Our new study in Nature Plants maps how "multi-tasking" enzymes in plants transfer nitrogen, a key step toward improving crop N use efficiency. 🌱
Big thanks to our collaborators from Max Planck, Hokkaido Univ, & MSU, and for support from @NSF and @DOE.
Learn more: rdcu.be/eFOFN
#PlantMetabolism
Big thanks to our collaborators from Max Planck, Hokkaido Univ, & MSU, and for support from @NSF and @DOE.
Learn more: rdcu.be/eFOFN
#PlantMetabolism
Mapping multi-substrate specificity of Arabidopsis aminotransferases
Nature Plants - Systematic characterization of Arabidopsis aminotransferase family enzymes uncovered many previously unrecognized activities and revealed their multi-substrate specificity, aspects...
rdcu.be
September 12, 2025 at 11:40 AM
Our new study in Nature Plants maps how "multi-tasking" enzymes in plants transfer nitrogen, a key step toward improving crop N use efficiency. 🌱
Big thanks to our collaborators from Max Planck, Hokkaido Univ, & MSU, and for support from @NSF and @DOE.
Learn more: rdcu.be/eFOFN
#PlantMetabolism
Big thanks to our collaborators from Max Planck, Hokkaido Univ, & MSU, and for support from @NSF and @DOE.
Learn more: rdcu.be/eFOFN
#PlantMetabolism
Reposted by Omar Kamileen
Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1
Discovery of homoharringtonine pathway enzymes reveals a whole plant model for coordinated biosynthesis
Plants have evolved to produce diverse molecules that inhibit protein translation. A lead example is homoharringtonine (HHT), both a key tool for ribosomal profiling and an FDA-approved treatment for ...
www.biorxiv.org
September 2, 2025 at 10:13 PM
Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1
Reposted by Omar Kamileen
The multilayered regulation of aromatic amino acid biosynthesis in plants: Trends in Biochemical Sciences www.cell.com/trends/bioch...
The multilayered regulation of aromatic amino acid biosynthesis in plants
The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for
the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp),
as well as vitamins, hormones, and ...
www.cell.com
August 28, 2025 at 12:20 AM
The multilayered regulation of aromatic amino acid biosynthesis in plants: Trends in Biochemical Sciences www.cell.com/trends/bioch...
Reposted by Omar Kamileen
Discovery happens less when you're trying to be the expert and more when you're trying to be the learner.
August 27, 2025 at 3:24 AM
Discovery happens less when you're trying to be the expert and more when you're trying to be the learner.
Reposted by Omar Kamileen
Protein Structural Phylogenetics academic.oup.com/gbe/article/...
Protein Structural Phylogenetics
Abstract. Protein structural phylogenetics is an interdisciplinary branch of molecular evolution that (i) uses 3D structural data to trace evolutionary his
academic.oup.com
August 26, 2025 at 4:33 PM
Protein Structural Phylogenetics academic.oup.com/gbe/article/...
Reposted by Omar Kamileen
Into natural product biosynthesis & tailoring enzymes? Frustrated by the lack of a dedicated resource to explore their functions? Tired of endless literature searches for reaction info? Meet the MITE database, freely available at mite.bioinformatics.nl. Preprint: doi.org/10.26434/che... (1/8)
August 21, 2025 at 10:52 AM
Into natural product biosynthesis & tailoring enzymes? Frustrated by the lack of a dedicated resource to explore their functions? Tired of endless literature searches for reaction info? Meet the MITE database, freely available at mite.bioinformatics.nl. Preprint: doi.org/10.26434/che... (1/8)
Reposted by Omar Kamileen
Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity www.nature.com/articles/s41...
rdcu.be/eAC91
rdcu.be/eAC91
Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets - Nature Biotechnology
Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity.
www.nature.com
August 13, 2025 at 6:27 PM
Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity www.nature.com/articles/s41...
rdcu.be/eAC91
rdcu.be/eAC91
Reposted by Omar Kamileen
Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology
A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale.
Single-gene-per-cell delivery coupled to an effective transcriptional selection system
www.biorxiv.org/content/10.1...
Single-gene-per-cell delivery coupled to an effective transcriptional selection system
www.biorxiv.org/content/10.1...
August 7, 2025 at 10:37 PM
Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology