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Medicine Nobel goes to three researchers who identified immune system’s security guards

Reposted by Saori Abe

Science Magazine @science.org · 3d

This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease

scim.ag

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Reposted by Saori Abe

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

Fragility fractures remain a common & serious
complication of long-term oral glucocorticoid therapy
that can affect all skeletal sites although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications

Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

www.thelancet.com

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Saori Abe @oriabe114.bsky.social · 5d

www.nature.com/articles/s41...

Original article📖→ www.nejm.org/doi/10.1056/...
“In vivo CD19 CAR T-cell therapy for refractory systemic lupus erythematosus.” N. Engl. J. Med.

#SLE #lupus #CART

In vivo CAR-T cell engineering in refractory SLE - Nature Reviews Rheumatology

Infused lipid nanoparticles were successfully used to generate CAR-T cells in patients with refractory systemic lupus erythematosus, achieving B cell depletion.

Dynamic control of autoreactive B cells from spontaneous germinal centers

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Reposted by Saori Abe

Waggoner Lab @labwaggoner.bsky.social · 7d

Urine proteins reveal distinct coagulation and complement cascades underlying acute versus chronic lupus nephritis @jci.org www.jci.org/articles/vie...

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Reposted by Saori Abe

Waggoner Lab @labwaggoner.bsky.social · 7d

Review @natrevimmunol.nature.com
Regulators of CD8+ T cell exhaustion
www.nature.com/articles/s41...

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Saori Abe @oriabe114.bsky.social · 7d

academic.oup.com/jimmunol/adv...
“Dynamic control of autoreactive B cells from spontaneous germinal centers” 🐭
#SLE #lupus #autoantibody

Abstract. Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled

academic.oup.com

3

Saori Abe @oriabe114.bsky.social · 7d

www.nature.com/articles/s41...

“Here we provide a high-resolution spatial kidney cell atlas of 57 samples from patients with RPGN ( #ANCA -associated GN, #lupus nephritis and anti-glomerular basement membrane-GN) to characterize the cell signaling pathways in glomerular crescent development.” 🫘🗺️

Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease - Nature Immunology

Here the authors provide a deep tissue analysis of patients with autoimmune kidney diseases, identifying a conserved spatiotemporal immune program for the development of glomerular crescents and sclerosis.

Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation

Reposted by Saori Abe

Waggoner Lab @labwaggoner.bsky.social · 12d

The loss of naïve-like precursor T follicular regulatory cells during COVID-19 correlates with autoantibody production
www.science.org/doi/10.1126/...

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Saori Abe @oriabe114.bsky.social · 13d

www.science.org/doi/10.1126/...

📖”Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation”
#RA #Tcell #Bcell #arthritis

Individuals at risk for rheumatoid arthritis exhibit inflammation and immune dysregulation before and during transition to active disease.

www.science.org

Saori Abe @oriabe114.bsky.social · 14d

📣Upcoming webinar announcement
👇Register for 🆓 😉❣️
#APLAR #AYR #webinar #WorldArthritisDay #gout

Lupus nephritis - Nature Reviews Disease Primers

Saori Abe @oriabe114.bsky.social · 14d

www.nature.com/articles/s41...
#lupusnephritis #lupus #SLE

This PrimeView highlights the mechanisms of lupus nephritis, and summarizes the epidemiology, diagnosis and management of this disease. It accompanies the Primer on this topic by Parodis et al.

Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjögren’s disease reveals common and distinct immune activation and fibroblast-mediated inflammation - N...

Reposted by Saori Abe

FOCIS - Federation of Clinical Immunology Societies @focisimmunology.bsky.social · 14d

Register today for the first FOCIS Journal Club! Free for all (non-members need a code at check-out)!

🔬 Dive into cutting-edge translational immunology
💬 Connect with experts & peers
🌍 Join the global FOCIS community

Learn more & register: zurl.co/elAO1

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Saori Abe @oriabe114.bsky.social · 16d

www.nature.com/articles/s41...
📖”Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjögren’s disease reveals common and distinct immune activation and fibroblast-mediated inflammation”
#Sjogren #SSA #centromere

Sjögren’s disease (SjD) can be split into different subtypes and these may have different molecular profiles. Here the authors compare anti-SSA and anti-centromere autoantibody positive SjD and show u...

Saori Abe @oriabe114.bsky.social · 16d

😊👍

A roadmap for defining “extrafollicular” B cell responses

Saori Abe @oriabe114.bsky.social · 16d

www.cell.com/immunity/abs...

📖A roadmap for defining “extrafollicular” B cell responses

#Bcell

The term “extrafollicular” is now being used expansively to describe a variety of B cell processes beyond the original use of the term, potentially obscuring important distinct immunological processes...

www.cell.com

Saori Abe @oriabe114.bsky.social · 17d

pubmed.ncbi.nlm.nih.gov/40964009/
Preprint 📖”Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus”

#lupus #Tph #Tfh

Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus - PubMed

Pathologic T cell-B cell interactions drive disease in systemic lupus erythematosus (SLE). The T cells that activate B cell responses include T peripheral helper (Tph) and T follicular helper (Tfh) ce...

pubmed.ncbi.nlm.nih.gov

Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in lupus nephritis

Saori Abe @oriabe114.bsky.social · 17d

www.sciencedirect.com/science/arti...
📖 Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in #lupus nephritis

“We identified VCAM1-expressing proximal tubule cells as components of an LN-specific inflammatory niche localised in the kidney cortex.“

Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), characterised by kidney inflammation, tubular injury, and interst…

www.sciencedirect.com

Human Atypical B Cells. An Overview - PubMed

Saori Abe @oriabe114.bsky.social · 17d

pubmed.ncbi.nlm.nih.gov/40968927/
📖 “Human Atypical B Cells. An Overview”

#ABC #Bcell #Immunologicalreviews

Owing to their participation in diverse infections and autoimmune diseases, B cells lacking expression of CD27, having low CD21 levels or expressing markers such as CD11c or T-bet, have gained major p...

pubmed.ncbi.nlm.nih.gov

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Saori Abe @oriabe114.bsky.social · 18d

😍
#doglover

Waggoner Lab @labwaggoner.bsky.social · 18d

Dogs extend verbal labels for functional classification of objects @currentbiology.bsky.social
www.cell.com/current-biol...

Saori Abe @oriabe114.bsky.social · 18d

www.nature.com/articles/s41...

“Using CRISPR-interference screens, we confirm that emVar-containing T cell cis-regulatory elements modulate target genes that regulate T cell proliferation, providing plausible mechanisms by which these variants alter #autoimmune disease risk.”
#Tcell #gene

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics

Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...

Arthritis Consumer Experts (ACE), in partnership with Lupus Canada, has launched the National Lupus Survey to learn directly from people living with lupus about their care experiences, challenges, and...

Reposted by Saori Abe

Arthritis Consumer Experts & JointHealth™ Programs @acejointhealth.bsky.social · 22d

Have your voice heard: National Lupus Survey now open! If you or someone you know lives with #lupus, please share 🙏

Take the survey now: surveymonkey.com/r/ACELCNatio...

#ArthritisAwarenessMonth #ACESurvey @schroeder-uhn.bsky.social @lupuschat.bsky.social @arthritispower.bsky.social

National Survey on Lupus

surveymonkey.com

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Saori Abe @oriabe114.bsky.social · 22d

www.nature.com/articles/s41...
“CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, rather than pathogen class, shape diversity in programming potential.”
#Tfh #Tcell #Immunosky

TFH cell programs by pathogen and species - Nature Immunology

CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, rather than pathogen class, shape divers...

‘Lipstick on a pig’: how to fight back against a peer-review bully

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Reposted by Saori Abe

Waggoner Lab @labwaggoner.bsky.social · 23d

‘Lipstick on a pig’: how to fight back against a peer-review bully @nature.com @katarinazimmer.bsky.social
www.nature.com/articles/d41...

Scientific societies, journals, editors and researchers are pushing back against mean-spirited peer reviews.