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Mrinmoy

@palmrinmoy.bsky.social

81 followers 110 following 18 posts

Postdoc @schuhlab.bsky.social. Former MSCA PhD fellow with @metorrespadilla.bsky.social. Oocytes, Embryos and Chromatin.

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Mrinmoy @palmrinmoy.bsky.social · Apr 23

How does the genome find its place in the 3D space of the nucleus after fertilization?

Out now @cellcellpress.bsky.social:
cell.com/cell/fulltext/…

👇 A thread 👇

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Mrinmoy @palmrinmoy.bsky.social · Jul 14

Defended my PhD last week! It’s been an incredible journey filled with challenges and exciting science. I'm deeply grateful to everyone who was part of it -especially @metorrespadilla.bsky.social for taking me on this ride. #PhDone 🎓

Reposted by Mrinmoy

Deutsche Forschungsgemeinschaft @dfg.de · May 12

#LeibnizPreis für exzellente Forschung in der #Epigenetik: Welche Mechanismen liegen der Zellplastizität und Reprogrammierung von Zellen zugrunde? An der Antwort, die zukünftig bei der Heilung von Organen helfen könnte, arbeitet Maria-Elena Torres-Padilla @metorrespadilla.bsky.social. Gratulation!

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Reposted by Mrinmoy

Schuh Lab @schuhlab.bsky.social · Apr 29

We’re proud to announce #OvoLabs, co-founded by Melina
@schuhlab.bsky.social, Agata Zielinska, and Oleksandr Yagensky. Building on decades of meiosis research, Ovo Labs aims to pioneer novel therapies to overcome the challenges of age-related infertility.

MPI for Multidisciplinary Sciences @mpi-nat.bsky.social · Apr 29

More hope for pregnancy: The start-up #OvoLabs develops drugs to improve egg quality & success of fertility treatments. For this, the company founded by Melina Schuh @schuhlab.bsky.social, Agata Zielinska, & Oleksandr Yagensky secures £4 million in start-up capital.
www.mpinat.mpg.de/5006185/pr_2...

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Reposted by Mrinmoy

Cell - a Cell Press journal @cp-cell.bsky.social · Apr 23

Now online! The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways

The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways

In vivo screening in mouse embryos provides insights into the functional interplay between chromatin and the nuclear envelope in the establishment of lamina-associated domains, the earliest feature of nuclear organization following fertilization.

dlvr.it

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Mrinmoy @palmrinmoy.bsky.social · Apr 23

Thank you @anajaneva.bsky.social for sharing our work. You and IES are deeply missed! ❤️

Reposted by Mrinmoy

Helmholtz Munich @helmholtzmunich.bsky.social · Apr 23

How DNA Self-Organizes in the Early Embryo 🧬

The new insights challenge the classical model of genome organization & could lead to new disease treatments.

👉 t1p.de/25q7l

@metorrespadilla.bsky.social @palmrinmoy.bsky.social @epihmgu.bsky.social @lmumuenchen.bsky.social

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Reposted by Mrinmoy

ME Torres-Padilla @metorrespadilla.bsky.social · Apr 23

Here is-🥳🥳😇 tremendous effort by @palmrinmoy.bsky.social brilliantly supported by @tamas-schauer.bsky.social &super help by federico,iliya,tsune,adam,@mamartirenom.bsky.social

Very happy to see this come to fruition- Look forward to feedback from colleagues !

More 👉 www.cell.com/cell/fulltex...

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Mrinmoy @palmrinmoy.bsky.social · Apr 23

Read the press release on our work from
@www.helmholtz-munich.de here:
www.helmholtz-munich.de/en/epigeneti...

Mrinmoy @palmrinmoy.bsky.social · Apr 23

It has been an incredible journey in the @epihmgu.bsky.social community, with lots of discussions and advice. Also thanks to everyone who provided plasmid constructs for designing the screen and help with sequencing!

Mrinmoy @palmrinmoy.bsky.social · Apr 23

Grateful to all co-authors and collaborators who contributed their expertise, especially during the revisions! 🙏Thank you @mamartirenom.bsky.social for your guidance with the meta-analysis of the huge dataset.

Mrinmoy @palmrinmoy.bsky.social · Apr 23

🧬 This work is the result of a lot of hard work over 5 years of my PhD.

Huge thanks to @metorrespadilla.bsky.social for trusting me with this challenging opportunity. Special mention to my bioinformatics buddy and plot wizard @tamas-schauer.bsky.social

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Mrinmoy @palmrinmoy.bsky.social · Apr 23

n/n✨ In summary:
LAD formation is epigenetically regulated, developmentally staged, and remarkably resilient!

Mrinmoy @palmrinmoy.bsky.social · Apr 23

9/n: Successful zygotic genome activation (ZGA) is typically associated with correct nuclear-lamina organization...

...but ZGA can occur even when lamina contacts are perturbed, especially at the resilient 2-cell stage.

Mrinmoy @palmrinmoy.bsky.social · Apr 23

8/n: Early embryos lack the constitutive heterochromatin pathway, including chromatin-compacting histone variants.

This absence enables the non-canonical embryonic chromatin to co-exist with a unique and dynamic LAD organization not seen in differentiated cells.

Mrinmoy @palmrinmoy.bsky.social · Apr 23

7/n: We found that compartment boundaries constrain LAD disruption and serve as scaffolding cues for organizing the genome.

LADs often spread only within B compartments, and LAD inversions follow compartment boundaries.

Mrinmoy @palmrinmoy.bsky.social · Apr 23

6/n:🧬 Even if LADs are disrupted in zygotes, embryos can rebuild LAD architecture at the 2-cell stage.

BUT:
Disruption at the 2-cell stage impairs preimplantation development.

Mrinmoy @palmrinmoy.bsky.social · Apr 23

5/n:🎯 H3K4me3 contributes to the robustness of nuclear organization.

HP1 proteins anchor broad H3K9me3 domains to the lamina. But H3K4me3 acts as a barrier, a chromatin boundary that blocks excessive lamina binding.
This balance is critical for correct nuclear organization.

Mrinmoy @palmrinmoy.bsky.social · Apr 23

4/n: We found that maternal inheritance of H3K27me3, not de novo methylation, is key to LAD formation in zygotes.

🎯 LAD establishment is maternally bookmarked and regulated through a PRC2–lamina antagonism.

Mrinmoy @palmrinmoy.bsky.social · Apr 23

3/n:💡 We discovered that chromatin pathways, not structural components, are the primary regulators of LADs in early embryos.

The interplay of H3K9, H3K27, and H3K4 methylation is a major player in shaping genome-lamina contacts.

Mrinmoy @palmrinmoy.bsky.social · Apr 23

2/n: Using in vivo perturbation screening + simultaneous LAD mapping, we built a toolbox to explore how chromatin dynamics guide nuclear organization post-fertilization.

🧬 A glimpse into the genome's first "address book" at the beginning of life.

Mrinmoy @palmrinmoy.bsky.social · Apr 23

1/n: We reveal how chromatin pathways shape genome-lamina interactions in early mouse embryos, and what happens when they go wrong.

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Mrinmoy @palmrinmoy.bsky.social · Apr 23

How does the genome find its place in the 3D space of the nucleus after fertilization?

Out now @cellcellpress.bsky.social:
cell.com/cell/fulltext/…

👇 A thread 👇

2 9 42

Reposted by Mrinmoy

Genes & Development @genesdev.bsky.social · Apr 22

In this study, Hermant et al. describe the evolution of the retrotransposon MERVL and its cis-regulatory transcription factor binding motifs, highlighting the phyloregulatory adaptation at play during early embryogenesis.

Learn more here:
➡️ tinyurl.com/gd352270

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Mrinmoy @palmrinmoy.bsky.social · Apr 21

🚨New paper alert!

RIF1 as a key in vivo regulator of replication timing consolidation during early mammalian development.

Another great collaborative effort from my time in the @metorrespadilla.bsky.social lab. Excited to see this one out!!

ME Torres-Padilla @metorrespadilla.bsky.social · Apr 21

Paper Out👇🥳 thanks to ALL authors, Nakatani-san @tamas-schauer.bsky.social @palmrinmoy.bsky.social and bluesky-less

RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔

👉 www.cell.com/developmenta...

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Reposted by Mrinmoy

ME Torres-Padilla @metorrespadilla.bsky.social · Apr 10

we've put a Review together 👇

Just came out at www.nature.com/articles/s41...

hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos

Enjoy :) - feedback welcome

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