Patricia Coelho
@patriciacoelho.bsky.social
Research Laboratory Manager @walmsley-lab.bsky.social in the CIR @edinuni-irr.bsky.social @edinburgh-uni.bsky.social 🇵🇹🏴 #neutrophils #hypoxia
Reposted by Patricia Coelho
Excited to share our work at @natcomms.nature.com
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
December 15, 2025 at 8:09 PM
Excited to share our work at @natcomms.nature.com
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
Reposted by Patricia Coelho
New study (Walmsley lab) has for the first time, found the set of proteins neutrophils express within a tumour at high detail. This tech has opened the door to understanding neutrophil roles in brain tumours such as glioblastoma but also more generally in health and disease states.
edin.ac/48JhnPq
edin.ac/48JhnPq
December 16, 2025 at 3:29 PM
New study (Walmsley lab) has for the first time, found the set of proteins neutrophils express within a tumour at high detail. This tech has opened the door to understanding neutrophil roles in brain tumours such as glioblastoma but also more generally in health and disease states.
edin.ac/48JhnPq
edin.ac/48JhnPq
Reposted by Patricia Coelho
How low blood oxygen can affect your body's immune defences 🛡️
A new study reveals that neutrophils have their genetic material modified by hypoxia and how the BCG vaccine may reverse this immune response.
Our article: edin.ac/49nENu4
Nature Immunology paper: www.nature.com/articles/s41...
A new study reveals that neutrophils have their genetic material modified by hypoxia and how the BCG vaccine may reverse this immune response.
Our article: edin.ac/49nENu4
Nature Immunology paper: www.nature.com/articles/s41...
October 28, 2025 at 10:30 AM
How low blood oxygen can affect your body's immune defences 🛡️
A new study reveals that neutrophils have their genetic material modified by hypoxia and how the BCG vaccine may reverse this immune response.
Our article: edin.ac/49nENu4
Nature Immunology paper: www.nature.com/articles/s41...
A new study reveals that neutrophils have their genetic material modified by hypoxia and how the BCG vaccine may reverse this immune response.
Our article: edin.ac/49nENu4
Nature Immunology paper: www.nature.com/articles/s41...
Reposted by Patricia Coelho
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
rdcu.be
October 28, 2025 at 11:24 AM
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Reposted by Patricia Coelho
Students celebrate their IRR internship 🧑🔬
For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes.
Read about the experience on IRR stories: edin.ac/4oPP33G
For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes.
Read about the experience on IRR stories: edin.ac/4oPP33G
Students celebrate their IRR internship | Institute for Regeneration and Repair | Institute for Regeneration and Repair
For four weeks this summer, IRR hosted local high school students as part of both the BioQuarter’s Summer Interns and University’s Career Ready programmes.
edin.ac
August 25, 2025 at 2:05 PM
Students celebrate their IRR internship 🧑🔬
For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes.
Read about the experience on IRR stories: edin.ac/4oPP33G
For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes.
Read about the experience on IRR stories: edin.ac/4oPP33G
Reposted by Patricia Coelho
Thanks to all who helped make this possible: the EMERGE team, research nurses, clinical & research collaborators & patients.
@kmechtler.bsky.social
@pranvera.bsky.social
@patriciacoelho.bsky.social
@ajmhowden.bsky.social
@mas-g.bsky.social
@walmsley-lab.bsky.social
@edinuni-irr.bsky.social
@kmechtler.bsky.social
@pranvera.bsky.social
@patriciacoelho.bsky.social
@ajmhowden.bsky.social
@mas-g.bsky.social
@walmsley-lab.bsky.social
@edinuni-irr.bsky.social
July 27, 2025 at 1:39 PM
Thanks to all who helped make this possible: the EMERGE team, research nurses, clinical & research collaborators & patients.
@kmechtler.bsky.social
@pranvera.bsky.social
@patriciacoelho.bsky.social
@ajmhowden.bsky.social
@mas-g.bsky.social
@walmsley-lab.bsky.social
@edinuni-irr.bsky.social
@kmechtler.bsky.social
@pranvera.bsky.social
@patriciacoelho.bsky.social
@ajmhowden.bsky.social
@mas-g.bsky.social
@walmsley-lab.bsky.social
@edinuni-irr.bsky.social
Reposted by Patricia Coelho
Super proud that my PhD paper is finally out! doi.org/10.1111/all.... RSV leaves long-lasting marks on the lung, potentially boosting future immune responses but also contributing to allergen sensitisation.
Epithelial Memory After Respiratory Viral Infection in Mice Results in Prolonged Enhancement of Antigen Presentation
RSV infection induces lasting epigenetic and transcriptional changes in LECs, upregulating MHC-I and MHC-II, further amplified by LPS exposure. This is accompanied by increased antigen uptake, proc...
doi.org
August 12, 2025 at 10:21 AM
Super proud that my PhD paper is finally out! doi.org/10.1111/all.... RSV leaves long-lasting marks on the lung, potentially boosting future immune responses but also contributing to allergen sensitisation.
Reposted by Patricia Coelho
Super happy to get this doi.org/10.1128/cmr.... #review out on long-term effects of respiratory viruses on lung epithelial cells!
The long reach of influenza and other respiratory viruses: from acute epithelial injury to post-viral lung disease | Clinical Microbiology Reviews
SUMMARYRespiratory viral infections cause extensive cell death in the lung epithelium, resulting
from both direct viral action and exuberant immune responses. Recovery following viral
infection requir...
doi.org
July 28, 2025 at 6:23 PM
Super happy to get this doi.org/10.1128/cmr.... #review out on long-term effects of respiratory viruses on lung epithelial cells!
Reposted by Patricia Coelho
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...
www.biorxiv.org
July 27, 2025 at 12:28 PM
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Reposted by Patricia Coelho
Welcome to our brand new Blue Sky page!
We are really excited to be here to engage with our network in friendly, informative and productive ways!
Join us 😊
We are really excited to be here to engage with our network in friendly, informative and productive ways!
Join us 😊
November 19, 2024 at 4:50 PM
Welcome to our brand new Blue Sky page!
We are really excited to be here to engage with our network in friendly, informative and productive ways!
Join us 😊
We are really excited to be here to engage with our network in friendly, informative and productive ways!
Join us 😊