Paula Tirado
@paulatiradom.bsky.social
40 followers 100 following 3 posts
Biologist 🧬| PhD researcher at @InstitutoCajal 🧠🔬 Adult and developmental neurogenesis in the hippocampus
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Reposted by Paula Tirado
aixa-v-morales.bsky.social
El próximo sábado 27 de septiembre estaremos hablando de la #enfermedadRara #SyndromeLambShaffer con las familias de los pacientes. Encuentro abierto a científicos, médicos y familiares de pacientes.
Nos vemos allí!
@institutocajal.bsky.social @csic.es @rarascsic.bsky.social 🧬🧠
Reposted by Paula Tirado
pilar-rguezm.bsky.social
Very happy to wrap up #SENC2025 presenting my poster. Thank you all for coming. Being located next to @paulatiradom.bsky.social has been really fun (and useful for adult neurogenesis enthusiasts!)
Reposted by Paula Tirado
aixa-v-morales.bsky.social
📢 If you are a fun of #neuraldevelopment and #neurodevelopmentaldisoderes you shouldn't miss this exciting Symposium at #SENC2025 Friday the 5th 9:00am with Silvia Capello, Daniel del Toro, Antonella Consiglio
and more. See you there ! @institutocajal.bsky.social
@csic.es @idibaps.bsky.social
paulatiradom.bsky.social
Only one day left until #SENC2025 ! ✨ Don't miss our poster on hippocampal neurogenesis 🧠 on Friday session from 15.00 to 18.30 S05-13.
Reposted by Paula Tirado
csic.es
CSIC @csic.es · Aug 14
🧬Un gen clave en el desarrollo embrionario protege la reserva de células madre en el cerebro adulto

🔬 La investigación del @institutocajal.bsky.social-#CSIC revela una ventana temporal después del nacimiento, crítica para establecer una neurogénesis adulta duradera

➡️ http://tiny.cc/iovq001
Reposted by Paula Tirado
aixa-v-morales.bsky.social
Ever wondered how adult #NeuralStemCells develop and acquire their lifelong potential?
Excited to share our latest work on the origin of #AdultNeurogenesis by Cris Medina
@paulatiradom.bsky.social Lingling Li & @pilar-rguezm.bsky.social now in @plosbiology.org🧪🧠
@institutocajal.bsky.social
👇🧵
New neurons are generated throughout adult life in the adult neurogenic niche in the hippocampus through activation of reversibly quiescent neural stem cells (NSCs). The cover highlights DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Medina-Menéndez et al. report that Sox5 is required to control the correct establishment of quiescence during the first postnatal weeks of dentate gyrus development, which is essential for establishing long-lasting adult neurogenesis. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002654
paulatiradom.bsky.social
So happy to see this one finally out! Have a read if you are interested in adult neurogenesis and neural development ✨🧠🧪
aixa-v-morales.bsky.social
Ever wondered how adult #NeuralStemCells develop and acquire their lifelong potential?
Excited to share our latest work on the origin of #AdultNeurogenesis by Cris Medina
@paulatiradom.bsky.social Lingling Li & @pilar-rguezm.bsky.social now in @plosbiology.org🧪🧠
@institutocajal.bsky.social
👇🧵
New neurons are generated throughout adult life in the adult neurogenic niche in the hippocampus through activation of reversibly quiescent neural stem cells (NSCs). The cover highlights DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Medina-Menéndez et al. report that Sox5 is required to control the correct establishment of quiescence during the first postnatal weeks of dentate gyrus development, which is essential for establishing long-lasting adult neurogenesis. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002654
Reposted by Paula Tirado
aixa-v-morales.bsky.social
Our new work on the establishment of quiescence in #adultneurogenesis , done at @institutocajal.bsky.social @csic.es, is out in @plosbiology.org .
Proud of a Great team, Cristina Medina,
@paulatiradom.bsky.social , Lingling Li , @pilar-rguezm.bsky.social and the rest ! 🎊🎉🧠
plosbiology.org
Quiescent hippocampal #NeuralStemCells (NSCs) support #neurogenesis in adulthood. @aixa-v-morales.bsky.social &co show that NSCs have different levels of quiescence & that Sox5 controls the balance between shallow & deep quiescence during hippocampal development @plosbiology.org 🧪 plos.io/44Su34u
Top: DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Image credit: Cristina Medina-Menéndez. Bottom: Summary of NSC quiescence dynamics during early postnatal DG development (left) and their alterations in Sox5null mice (right).
Reposted by Paula Tirado
pilar-rguezm.bsky.social
💥 We are very proud of our last paper now plublished in @plosbiology.org ! Really thorough study of how NSCs acquire quiescence during early postnatal stages by @aixa-v-morales.bsky.social lab. Great job @paulatiradom.bsky.social 💪. Congrats!
plosbiology.org
Quiescent hippocampal #NeuralStemCells (NSCs) support #neurogenesis in adulthood. @aixa-v-morales.bsky.social &co show that NSCs have different levels of quiescence & that Sox5 controls the balance between shallow & deep quiescence during hippocampal development @plosbiology.org 🧪 plos.io/44Su34u
Top: DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Image credit: Cristina Medina-Menéndez. Bottom: Summary of NSC quiescence dynamics during early postnatal DG development (left) and their alterations in Sox5null mice (right).
Reposted by Paula Tirado
Reposted by Paula Tirado
institutocajal.bsky.social
🧠✨ Imagen del mes | Hipocampo en desarrollo
Esta región del cerebro, clave para la memoria, sigue generando neuronas en la adultez. En el Instituto Cajal, Paula Tirado investiga cómo se forman y regulan las células madre que lo hacen posible. Descubre más aquí https://tr.ee/7hDKcM
Reposted by Paula Tirado
sergiuppasca.bsky.social
This week we welcome on campus 2025 class of students for our hands-on Stanford Brain Organogenesis course.
With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to their labs.
paulatiradom.bsky.social
Mi amiga y artistaza @mateohenar.bsky.social ha preparado una exposicion de ilustraciones inspiradas en el trabajo de mujeres científicas y he tenido la gran suerte de que me incluya 💜👩🏻‍🔬✨ Podéis disfrutarla desde ya en Madrid o en su web ⬇️ retratodelamujerenciencia.my.canva.site
Reposted by Paula Tirado
institutocajal.bsky.social
A lo mejor, algún día, el #8M deja de celebrarse porque se han cumplido todas sus reinvindicaciones y ya no es relevante.

Mientras eso no sea así, habrá que insistir, en la ciencia, en el trabajo, y en cualquier lado.

Feliz #diainternacionaldelamujer
Reposted by Paula Tirado
pilar-rguezm.bsky.social
En un #28F de hace 2 años escribí un pequeño hilo en Twitter para hablar de una enfermedad rara que, cada día, lo es un poco menos: el síndrome de Lamb-Shaffer. ¿Os parece si hacemos un poco de mudanza y me lo traigo a Bluesky? 📦
⬇️ Aquí viene un poco de copia-pega
Reposted by Paula Tirado
crick.ac.uk
This is an image of a living zebrafish embryo with the heart visible, labelled with fluorescent proteins and taken using confocal #microscopy 🧪🔬

Image credits: Rashmi Priya and Srinivas Allanki
A black and white face-like image with large buggy eyes. In the middle there is a small heart-shaped structure with tendrils coloured in a variety of colours like purple, red and yellow.