Mannowetz and Chung et al. investigated the properties and efficacy of the RARα selective antagonist YCT-529 as a male contraceptive. Mouse and non-human primates experienced fertility inhibition through disruption of spermatogenesis which was reversed upon cessation of oral administration.

Maatz, Lindberg et al. identify molecular alterations and immune response changes in endomyocardial biopsies from patients with myocarditis after COVID-19 infection, after anti-COVID-19 vaccination or from non-COVID-related causes.

This narrative review summarizes the epidemiology and pathophysiology of out-of-hospital cardiac arrest and sudden cardiac death and discusses the clinical assessment and treatment of apparently healthy young adults with no known structural heart or coronary artery disease.

In a randomized controlled trial in individuals with persistent atrial fibrillation, an individualized ablation procedure, in which areas with abnormal electrophysiological characteristics—as detected by an AI algorithm—were targeted for ablation, led to improved efficacy for reducing arrhythmia recurrence at 12 months following the ablation procedure.

AbstractBackground. Attention-deficit/hyperactivity disorder (ADHD) is one of the most commonly diagnosed mental disorders in children. For many patients,

About 80 percent of manufacturing investments spurred by a Biden-era climate law have flowed to Republican districts. Efforts to stop federal payments are already causing pain.

A former Republican director of USAID says the agency is critical to U.S. interests and can’t be abolished or folded into the State Department.

Podcast Episode · The Ezra Klein Show · 02/02/2025 · 14m

BMC Public Health

Epicardial engineered heart muscle allografts from induced pluripotent stem cell-derived cardiomyocytes can safely and effectively remuscularize chronically failing hearts in rhesus macaques, leading to improved cardiac function and paving the way for human clinical trials.