The Polygenic Score Catalog
@pgscatalog.bsky.social
An open database of polygenic scores and the relevant metadata required for accurate application and evaluation
https://www.pgscatalog.org/
https://www.pgscatalog.org/
We hope it's easy to use with tutorials for UKB (pgsc-calc.readthedocs.io/en/v3-alpha....) & All of Us (pgsc-calc.readthedocs.io/en/v3-alpha.... )! But feel free to contact us on Github: github.com/PGScatalog/p...!
With that, happy holidays from the PGS Catalog team! 🎁 🎄
With that, happy holidays from the PGS Catalog team! 🎁 🎄
UK Biobank Research Analysis Platform tutorial | PGS Catalog Calculator documentation.
How to calculate polygenic scores on the UK Biobank Research Analysis Platform
buff.ly
December 15, 2025 at 3:44 PM
We hope it's easy to use with tutorials for UKB (pgsc-calc.readthedocs.io/en/v3-alpha....) & All of Us (pgsc-calc.readthedocs.io/en/v3-alpha.... )! But feel free to contact us on Github: github.com/PGScatalog/p...!
With that, happy holidays from the PGS Catalog team! 🎁 🎄
With that, happy holidays from the PGS Catalog team! 🎁 🎄
The new alpha only implements PGS scoring at the moment, but the roadmap will reimplement our existing genetic ancestry tools! Lot's of under-the-hood optimisation using python (zarr, dash), and it only takes VCF or BGEN input atm. github.com/PGScatalog/p...
buff.ly
December 15, 2025 at 3:44 PM
The new alpha only implements PGS scoring at the moment, but the roadmap will reimplement our existing genetic ancestry tools! Lot's of under-the-hood optimisation using python (zarr, dash), and it only takes VCF or BGEN input atm. github.com/PGScatalog/p...
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
GitHub - PGScatalog/pgsc_calc: The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation
The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation - PGScatalog/pgsc_calc
github.com
November 11, 2025 at 5:43 PM
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
Another highlight from this release is a new score for all-cause dementia, 🔗: www.pgscatalog.org/score/PGS005.... Thanks to D'Aoust et al. for sharing!
A polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
April 17, 2025 at 11:11 AM
Another highlight from this release is a new score for all-cause dementia, 🔗: www.pgscatalog.org/score/PGS005.... Thanks to D'Aoust et al. for sharing!
Also out today is this multi-ancestry PGS for PSA! 🔗: www.pgscatalog.org/publication/...
📣 Happy to share our latest paper - an exciting step forward for PSA genetics with a much larger and more diverse GWAS and a more predictive PGS ⚡️
@johnwitte.bsky.social
@stanford-cancer.bsky.social
@stanfordmedicine.bsky.social
@johnwitte.bsky.social
@stanford-cancer.bsky.social
@stanfordmedicine.bsky.social
📢ONLINE @naturegenet.bsky.social
📰Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.
By Thomas Hoffmann, @lindakachuri.bsky.social, @johnwitte.bsky.social and co.
⬇️
www.nature.com/articles/s41...
📰Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.
By Thomas Hoffmann, @lindakachuri.bsky.social, @johnwitte.bsky.social and co.
⬇️
www.nature.com/articles/s41...
February 26, 2025 at 2:44 PM
Also out today is this multi-ancestry PGS for PSA! 🔗: www.pgscatalog.org/publication/...