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Reposted by Philip Ruthig

LMU Open Science Center @lmu-osc.bsky.social · 28d

💡 Explore how practices from distributed, open-source software can make science more professional, open, and collaborative! Attend the “Science as amateur software development” lecture by Prof. Dr. @rmcelreath.bsky.social on Wed 17 Sept, 9:00.
👉 Register here: www.pretix.osc.lmu.de/lmu-osc/OSSS...

Promotional poster for the LMU Open Science Center Summer School 2025 Public Lecture. The poster features a photo of speaker Prof. Dr. Richard McElreath. The text states the lecture focuses on science as amateur software development, time and date of lecture being 9:00-10:00 CEST on Wednesday September 17 2025, and instructions to register online. Logos of LMU Open Science Center, LMU, and Universitätsbibliothek München are displayed at the bottom.

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Philip Ruthig @philipruthig.bsky.social · Aug 30

Wrote the same thing as a tweetorial on X, got a single interaction with the tweet. I guess it is finally time to leave that place for good

Philip Ruthig @philipruthig.bsky.social · Aug 21

How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are?

In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️

plos.io/4mq5tOy
#neuroscience #neuroskyence #whitematter #deeplearning

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Philip Ruthig @philipruthig.bsky.social · Aug 26

😱

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Reposted by Philip Ruthig

PLOS Biology @plosbiology.org · Aug 22

#Myelination enables faster signal propagation in the brain, but takes more energy & space. @philipruthig.bsky.social &co reveal how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @plosbiology.org 🧪 plos.io/4mq5tOy

Arrangement of raw data, semantic, and instance segmentation of human corpus callosum fibers, acquired by transmission electron microscopy. The data used for this image were generated by Maria Morozova, David Edler von der Planitz, and Philip Ruthig. All cover Art was created by the MPI for Human Cognitive and Brain Sciences Graphics department (Andrea Sandmann)

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Philip Ruthig @philipruthig.bsky.social · Aug 21

That leaves me to thank my excellent co-1st author David Edler von der Planitz, and our collaborators and co-supervisors @siawooshmr.bsky.social, @nikweiskopf.bsky.social, Evgeniya Kirilina, and Markus Morawski!

A collaborative project of @mpicbs.bsky.social and @unileipzig.bsky.social!

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Philip Ruthig @philipruthig.bsky.social · Aug 21

That concludes the skeetorial - check the full paper @plosbiology.org: plos.io/4mq5tOy

bsky.app

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Philip Ruthig @philipruthig.bsky.social · Aug 21

Furthermore, we supply other scientists with the necessary functions that describe our experimental data - important for anyone who might want to simulate brain-wide activity!

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Philip Ruthig @philipruthig.bsky.social · Aug 21

Based on this anatomical data, we estimate that corpus callosum fibers conduct signals ~25% faster than short white matter fibers, and show a higher portion of very fast fibers (>8m/s).

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Philip Ruthig @philipruthig.bsky.social · Aug 21

In contrast, the g-ratio distribution of both sets of fibers is almost identical!

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Philip Ruthig @philipruthig.bsky.social · Aug 21

Additionally, both groups of fibers seems to have a large amount of fibers near the g-ratio of 0.6. This seems to be the equilibrium for long fibers where energy expenditure by the organism, space constraints, velocity and efficiency of signal transduction meet.

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Philip Ruthig @philipruthig.bsky.social · Aug 21

We fitted a generalized extreme value function (GEV) to all of the distributions and found that both axon diameter and myelin thickness is downscaled in shorter fibers.

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Philip Ruthig @philipruthig.bsky.social · Aug 21

Using a fully automated deep learning analysis, we segmented each structure in the TEM data and analyzed the axonal diameter, myelin thickness, and g-ratio (ratio between axon radius & myelin thickness).

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Philip Ruthig @philipruthig.bsky.social · Aug 21

To investigate this issue, we sampled white matter tissue from body donors from a variety of superficial white matter (mostly short fibers) and corpus callosum areas (very long fibers), and prepared them for transmission electron microscopy.

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Philip Ruthig @philipruthig.bsky.social · Aug 21

How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are?

In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️

plos.io/4mq5tOy
#neuroscience #neuroskyence #whitematter #deeplearning

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Philip Ruthig @philipruthig.bsky.social · Aug 21

Out now in @plosbiology.org: our recent study on white matter myelination and axon diameters in long and short fibers of humans! Skeetorial coming soon :)

PLOS Biology @plosbiology.org · Aug 21

#Myelination enables faster signal propagation in the brain, but takes more energy & space. @philipruthig.bsky.social &co reveal how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @plosbiology.org 🧪 plos.io/4mq5tOy

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Reposted by Philip Ruthig

Christophe 🔬 L @christlet.bsky.social · Jul 14

When a microscope facility user asks about how to make a red/green overlay

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Reposted by Philip Ruthig

Markus Elsner @markuselsner.bsky.social · Jun 23

Our spin-off company is hiring a COO. (Stay tuned for more job offers)

www.linkedin.com/jobs/view/42...

Deep Piction hiring Chief Operating Officer in Greater Munich Metropolitan Area | LinkedIn

Posted 10:54:20 AM. Chief Operating Officer (COO)Location: Munich, Germany (On-site) Employment Type: Full-timeAbout…See this and similar jobs on LinkedIn.

www.linkedin.com

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Reposted by Philip Ruthig

☁️ retornam ☁️ @retornam.bsky.social · Jun 21

bsky.app/profile/matt...

Meme showing Principal Skinner from
The Simpsons in two frames.

The first frame has him with the words "Am I out of touch?"

The second frame has him with the words “No it is the entire corpus of human knowledge that is wrong."

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Reposted by Philip Ruthig

Josh Moore @joshmoore.bsky.social · Jun 11

🚀 We’re hiring again! Join @gerbi-gmb.de as a Software Developer!

💻 Build scalable #bioimaging solutions

🌍 Collaborate globally

🎯 Contribute to open science through #OME #Zarr

📣 Tell your #NGFF friends.

Remote, full-time. Apply by 30 June 2025: All submissions via bit.ly/gerbi-jobs-2...

Screenshot of the PDF available at https://cloud.gerbi-gmb.de/s/6LrYfMByymPnHP5/download/2025_OME-Zarr_sw_developer.pdf

Screenshot of the PDF available at https://cloud.gerbi-gmb.de/s/y4rBGFM6dXn8Jkr/download/2025_OME-Zarr_web_developer.pdf

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Reposted by Philip Ruthig

Karl Deisseroth @deisseroth.bsky.social · May 30

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...

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Philip Ruthig @philipruthig.bsky.social · May 20

Signs I am, indeed, living in Munich, pt 1:

I just paid 9€ for a pretzel and croissant.

Philip Ruthig @philipruthig.bsky.social · May 18

Definitely going to, soon!

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Reposted by Philip Ruthig

Blake Richards @tyrellturing.bsky.social · May 12

+1000

I think AI will help us do scientific research in numerous ways, but the bulk of the work that real scientists do is not anything that "AI scientists" will be able to do.

Ted Underwood @tedunderwood.com · May 12

This pattern is going to repeat in one domain after another, and gradually force us to admit that 60% of every job is networking, knowing who to trust, and doing poorly justified risk/benefit assessment.

Eugene Vinitsky 🍒 @eugenevinitsky.bsky.social · May 12

The “AI Scientist” work, while interesting, sort of mischaracterizes the process of science as generating hypotheses and running experiments. The actual thing is so much more interesting: interpreting unclear evidence, reasoning about unsteady foundations, etc.

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Philip Ruthig @philipruthig.bsky.social · May 7

📌

Reposted by Philip Ruthig

Jo Wolff @jowolff.bsky.social · May 3

Every now again it’s useful to repeat advice about accessing papers that are behind a paywall that excludes you. Email the author. My estimate is that 90% of academics are so thrilled that a living, breathing, possibly even reading, person shows interest that they will swiftly send you a copy.

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