Lightnews — Scholar-powered news

Reposted by Markus Elsner

Randall Munroe @xkcd.com · 1d

4-panel comic. (1) [person in front of window, shaped like a trapezoid with a curved top] This weekend, I had to make an oversized screen for a porch window. (2) [person sitting with hands on head surrounded by images of assorted equations and measurements] It involved countless tiny problems, each somehow way harder than it should be. Oblique angles. Curved edges. Noncoplanarity. (3) [person in front of window with screen on it, with building detritus strewn on the ground] ...I solved them all. I measured precisely. I did trigonometry. I made custom parts. And it fit *perfectly.* No gaps, no ripples. (4) [person typing at computer] I know that your foundation normally limits its purview to physics, medicine, peace, chemistry, and literature. However, if you review the attached photos showing how well the screen fits into the...

Markus Elsner @markuselsner.bsky.social · 1d

Same in Germany until few weeks ago, when our conservatives took a leaf out of the GOP's playbook. Hope they will realize in time that this only benefited the far right

Cathleen Crudden @cathleencrudden.bsky.social · 2d

You know what's great about Canada's supreme court? I don't know any of their names or their political affiliations.

derek guy @dieworkwear.bsky.social · 2d

i had no idea this is how canada's supreme court dresses

1

Reposted by Markus Elsner

Cathleen Crudden @cathleencrudden.bsky.social · 2d

You know what's great about Canada's supreme court? I don't know any of their names or their political affiliations.

derek guy @dieworkwear.bsky.social · 2d

i had no idea this is how canada's supreme court dresses

Nine members of the Canadian Supreme Court sitting for a photo. They are dressed in red robes trimmed in white.

1 3 30

Reposted by Markus Elsner

Waggoner Lab @labwaggoner.bsky.social · 1d

@biorxivpreprint.bsky.social Bioengineered human tonsil organoids as an immuno-engineering platform for evaluating immune functions @nusingapore.bsky.social
www.biorxiv.org/content/10.1...

1 3

Reposted by Markus Elsner

Addgene @addgene.bsky.social · 3d

Thanks for sharing the plasmids at Addgene! www.addgene.org/browse/artic...

1 3

Markus Elsner @markuselsner.bsky.social · 3d

With the Nobel week coming up, I hope that next gen sequencing will finally be honored

1

Markus Elsner @markuselsner.bsky.social · 3d

💯

Christophe 🔬 L @christlet.bsky.social · 3d

Never forget #saladsunday

2

Reposted by Markus Elsner

AnniZLab: [🦠, 🧬 , ✨] @annizlab.bsky.social · 3d

BindCraft: an AlphaFold2-powered de novo protein binder design tool 🧬✨
Tested in some bacterial systems too! Designs so far are short peptides or mini-domains. Looking forward to long/full protein design ahead! 🧪 #microsky
www.nature.com/articles/s41...

One-shot design of functional protein binders with BindCraft - Nature

BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

www.nature.com

10 41

Reposted by Markus Elsner

Eric Topol @erictopol.bsky.social · 6d

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...

6 68 220

Markus Elsner @markuselsner.bsky.social · 7d

but, but CHINA:

1

Reposted by Markus Elsner

Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 8d

What a line from the Pope! I am so pleased he is carrying on Pope Francis’ advocacy for immigrants.

More pointedly, the pope said, "Someone who says, I'm against abortion, but is in favor of the death penalty is not really pro-life. Someone who says, I'm against abortion but I'm in agreement with the inhuman treatment of immigrants in the United States, I don't know if that's pro-life."

220 4.5K 18K

Markus Elsner @markuselsner.bsky.social · 8d

I don't know why I keep thinking about this Tacitus quote today:
"They create a desolation and call it peace."

1 3

Reposted by Markus Elsner

Christophe 🔬 L @christlet.bsky.social · 8d

Link for today's #GEF25 stream:
www.youtube.com/watch?v=eG32...

3 8

Reposted by Markus Elsner

Randall Munroe @xkcd.com · 9d

Hiking

xkcd.com/3147/

Comic. [Two people hiking up mountain] PERSON 1: Okay, we’re nearing the next downhill segment I’ll put in the order. ...Confirming start and end points… Submitted! [water slide being dropped from above by drones] PERSON 2 with long hair: Look, here it comes! [Waterslide positioned on downhill slope of mountain with both people riding down] BOTH: Wheeee [Waterslide carried back into the air] [Both people continuing to hike up next slope] [caption] On-demand waterslide delivery has really improved the whole hiking experience.

24 240 2.4K

Reposted by Markus Elsner

Nature Biotechnology @natbiotech.nature.com · 9d

Funding and public support for vaccines in the United States is at an all-time low. Promising research is resulting in effective antivirals, but they should not take the place of vaccines go.nature.com/4gijtYv

2 3

Reposted by Markus Elsner

Denis Wirtz @deniswirtz.bsky.social · 10d

Multimodal SRS imaging reveals metabolic remodeling in ovarian precancerous lesions.

In collaboration with Prof. Lingyan Shi (UCSD), we integrated spatial metabolomics into a new 3D tissue mapping workflow at single-cell resolution

More here: www.biorxiv.org/content/10.1...

1 6 24

Markus Elsner @markuselsner.bsky.social · 10d

Tissue clearing community as well!

1 2

Reposted by Markus Elsner

Nature @nature.com · 10d

Nature research paper: In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

go.nature.com/3IeODUh

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature

In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

go.nature.com

12 37

Markus Elsner @markuselsner.bsky.social · 10d

Haahah, I also only realized this week

1

Reposted by Markus Elsner

Following Hadrian @followinghadrian.bsky.social · 10d

Marking #WorldRiversDay with photos of the Euphrates River in Turkey.

1 9 55

Reposted by Markus Elsner

Rita Strack @ritastrack.bsky.social · 10d

@ewerslab.bsky.social Helge Ewers is starting the day strong at #GEF25. Check out this incredible work on cytokinesis! www.biorxiv.org/content/10.1...

2 2 16

Reposted by Markus Elsner

Christian Thiels @christianthiels.bsky.social · 11d

Myriam Bloch, six years old when she was brutally murdered by German Nazis. An estimated 1.5 million children fell victim to the Holocaust. Lest we forget. 🕯️

Auschwitz Memorial @auschwitzmemorial.bsky.social · 12d

27 September 1937 | A French Jewish girl, Myriam Bloch, was born in Metz.

She arrived at #Auschwitz on 20 December 1943 in a transport of 850 Jews deported from Drancy. She was among 505 of them murdered in gas chambers after the selection.
--

Children at Auschwitz: https://youtu.be/aYKx_zpLSqA

A vintage photo of a young gile standing and holding a toy. The girl is smiling and dressed in a light-colored outfit with curly hair.

9 32

Reposted by Markus Elsner

Rita Strack @ritastrack.bsky.social · 11d

When I left the bad place, I thought my social media life was essentially over, and I found that heartbreaking, because it's an important part of my life and my work. But it wasn't true! I am humbled to have hit 14K followers here. Thank you.

3 1 110

Reposted by Markus Elsner

Eric Topol @erictopol.bsky.social · 12d

Checkpoint inhibitors are the mainstay of cancer immunotherapy. Here's a new review article for the current state of the science and where we're headed www.science.org/doi/10.1126/...

4 32 140

Markus Elsner @markuselsner.bsky.social · 12d

Argg, I wonder what our right wing idiots will do, if they ever come to power.

Karl Jacoby @karl-jacoby.bsky.social · 12d

Only an administration intent on committing war crimes in the present and future would stoop to calling Wounded Knee a "battle" rather than what it truly was: a massacre of over 250 Lakotas, mainly women, children, and the elderly. 1/

1