Sam Foley
@physfoley.bsky.social
800 followers 530 following 520 posts
Physics of membranes and self-assembly || Biophysics postdoc at Johns Hopkins || Previously Penn State -> Carnegie Mellon || views are now yours, good luck || /dʒɪf/ || www.samuelfoley.com
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physfoley.bsky.social
I’m excited to finally share our new preprint! Membrane-associated assembly processes like CME function as precisely-tunable, spatially targetable, robust on/off switches that don’t require energy at decision-time.

arxiv.org/abs/2505.17290

🧪
Top: Illustration of a lattice model of self-assembly coupled to membrane and receptor binding. An arrow along the bottom indicates that increases to various model parameters result in assembly nucleation events.
Bottom left: Theoretical assembly "phase diagram" showing the extent of assembly in the membrane adhesiveness-receptor concentration plane.
Bottom right: Decision boundaries, like the sharp transition seen on the left, plotted for various values of receptor affinity.
physfoley.bsky.social
Chicago style is now officially sanctioned though
Reposted by Sam Foley
keithwdickinson.bsky.social
Today is a day when arts degrees are worthless, but the product of those degrees is so valuable it would kill an entire industry if they were made to pay for it.
physfoley.bsky.social
Pittsburgh being exactly on the boundary between Northeast and Midwest is perfect.
Reposted by Sam Foley
rosalafersousa.bsky.social
Over the weekend ICE abducted an NIH contractor when he showed up to a courthouse for his green card hearing. He is documented. His wife is a citizen.

He is also member of the skeleton crew of animal care staff that works through a shutdown, to ensure the health and wellbeing of research animals.
physfoley.bsky.social
I wrote up some notes on Brownian dynamics of (nearly flat) Helfrich membranes to help myself learn, and decided to post them publicly in case anyone else finds them helpful. Starting from Stokes equations and going through stochastic simulation in Fourier space.

www.samuelfoley.com/misc/
Misc - Sam Foley
www.samuelfoley.com
physfoley.bsky.social
Leaves the door open for future awards, I suppose
We've had one, yes, but what about second Nobel?
physfoley.bsky.social
Or a really fast sketch artist given the assignment the night before the announcement?
physfoley.bsky.social
🤔
techmeme.com
OpenAI's computing deals with Nvidia, AMD, Oracle, and others have topped $1T, commitments that dwarf its revenue and raise questions about how it can fund them (Financial Times)

Main Link | Techmeme Permalink
Reposted by Sam Foley
physfoley.bsky.social
Hard to trust the safety of new verb additives these days what with all the corporate lobbying from Big Dictionary.
physfoley.bsky.social
A very expensive day later, and the consensus seems to be: he had a tummy ache
physfoley.bsky.social
Yes, but I don't have tremendously good reasons for not picking it. I picked Ubuntu because it has by far the most community support online, making it easy to fix problems by googling. I picked XFCE because it's lightweight and a mature project.
physfoley.bsky.social
XFCE is definitely minimalist, light and snappy. I didn't feel like I had to make any compromises choosing it over GNOME.
physfoley.bsky.social
The application I use is called PCem, and it supports a ton of architectures. I can't remember if I followed a specific guide when I first set it up, but the trickiest part is picking the right combination of hardware and drivers. And I was talking about the Star Wars episode 1 video game lol
physfoley.bsky.social
I kept a small Win11 partition for dual booting but only ended up booting it up like 3 times. The biggest issue is the lack of MS Office desktop applications on Linux (there are some things LibreOffice just can't do compatibly), but I just run them in a Windows VM rather than rebooting to Windows.
physfoley.bsky.social
I've been using a Thinkpad L14 Gen 1 with a Ryzen 7 PRO 4750U running Xubuntu for about a year and a half now and it's been great for my work, which mainly consists of coding in Python, Julia, and C++, and reading and writing papers.
physfoley.bsky.social
Never a good day to be at the pet ER with the kitty
physfoley.bsky.social
I'm curious what your main qualms are with VScode. I resisted for a while due to bad memories of visual studio, but I was pleasantly surprised by how nice it is to use, and on Linux at that.
physfoley.bsky.social
Nothing like compiling a Pentium processor emulator so you can install Windows 98 with a properly emulated Voodoo graphics card and play some classic games lost to that weird intermediate period between what works in DOSbox and what still runs on modern OSes.
physfoley.bsky.social
I know there are more important things to worry about, but the NIH website main banner being a super shitty AI-generated image pisses me off so much. "Know your blood pressure numbers" yeah they got me there, that is good advice after seeing the picture.
physfoley.bsky.social
This is what I've done ever since I realized journals provide RSS feeds
Reposted by Sam Foley
philipcball.bsky.social
We seem on the verge of so many breakthroughs in disease control right now, and yet are facing the ravings of a governing death cult. No news service should be treating this stuff as some kind of "controversy". It's a derangement.