This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

🔬 Braf : le verrou moléculaire que les cellules cancéreuses peuvent forcer - Une équipe internationale, dont des scientifiques bordelais du CBMN*, explorent une piste prometteuse pour entraver ces cellules cancéreuses :

Flying start to the #iubmbkinases meeting in beautiful Queenstown, NZ. Jubilee Award from IUBMB to Kevan Shokat yesterday, and a kinase masterclass from Susan Taylor this morning

New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation.

Learn more in this week's issue: scim.ag/44uRorm

🚨 Fully funded PhD position in plant & structural biology! Join the @eliastahl.bsky.social lab in collaboration with our team. Exciting project on protein structure/function in plants 🌱. Contact us for details!
#PlantBiology #StructuralBiology #PhDposition @iecb.bsky.social

Fascinating and diverse programme of talks at the joint Autophagy UK and @ukproteostasis.bsky.social meeting in Dundee this week! & super happy to have the chance share our #pseudoligase work 📣

🎉 New paper out in Science!
In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer.
Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social

With less than a month to submit abstracts for the
@iubmb.bsky.social Focussed Meeting on (pseudo)Kinases in stunning Queenstown, we are delighted to announce travel scholarships for selected ECRs thanks to @biologists.bsky.social and the Maurice and Phyllis Trust! www.ivvy.com.au/event/IUBMB25/

We are recruiting 🤩🤩🤩!!! If you are looking to establish ylur lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!

A few more days to apply for postdoctoral positions in my group. We investigate :

- tau amyloid formation at a molecular level

- tau LLPS

- tau-spliceosome interaction in tauopathies.

More info here : www.fichou-lab.cnrs.fr/en/home

Reminder - still one month to apply to be a tenure track group leader at MRC LMB. Please do reach out for any information.

Hi Vahid, yes! International students with a master's degree from a non-French university can definitely apply.

Here is the link to apply: aap.u-bordeaux.fr/siaap/pub/ap...

(4/4) 📍 University of Bordeaux, France
🎓 Funding: UB PhD Scholarship
📅 Deadline: March 17, 2025

Interested? DM me! 📩

#PhD #StructuralBiology #Cryo-EM #Nanobodies #CancerResearch #Fellowship #Science

(3/4) 💊 Project 2: Nanobody development for kinase targeting – Engineer therapeutic nanobodies to selectively inhibit disease-relevant kinases.
🔗 Apply here: adum.fr/as/ed/voirpr...

(2/4) 🔬 Project 1: Structural biology of protein kinases in cancer – Use cutting-edge cryo-EM, X-ray crystallography, and biophysics to study key kinases in disease.
🔗 Apply here: adum.fr/as/ed/voirpr...

(1/4) 🚀 PhD Fellowship Opportunity @iecb.bsky.social @univbordeaux.bsky.social University of Bordeaux!
Looking for talented international Master’s graduates to apply for a PhD fellowship via the UB PhD Scholarship.

Two exciting projects in kinase biology & nanobody therapeutics! ⬇️ Please Repost

(2/4) 🔬 Project 1: Structural biology of protein kinases in cancer – Use cutting-edge cryo-EM and biophysics to study key kinases in Human disease.

🔗 Apply here: adum.fr/as/ed/voirpr...

Join us next week on Friday the 7th, at 11 am, in our IECB amphitheater to learn a whole lot on the design and applications of enzyme cascades for organic synthesis 🤓🧪👩‍🔬⚗️! Guest speaker Prof. Sabine Flitsch from the University of Manchester 🤩!!!

www.iecb.u-bordeaux.fr/evenements/i...

Looking forward to be there! The list of speakers is impressive. So proud to be part of it.

Thanks Rémi, it is indeed time for me to change my horizon here.