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preprintclub.bsky.social
Preprint Club - Immunology
@preprintclub.bsky.social
600 followers 150 following 100 posts
Cross-Institutional Journal Club. We review immunology #preprints and highlight our favourites. Check our website 👉 https://www.preprintclub.com/
www.preprintclub.com
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Dec 10
#PreprintClub is now on Bluesky!

Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · 1d
Izabella Valdez from Mount Sinai will present a preprint from the Moriarity lab at @UMN on FAS and TGFβR2 base editing in primary T cells
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · 1d
Today, Nicolas Ruffin from Karolinska will present a preprint from @josephsunlab.bsky.social on how STAT3 operates as an inflammation-dependent transcriptional switch!
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · 1d
Today at #PreprintHub2, Teresa Neuwirth from

@cemm.oeaw.ac.at will present a #preprint by

@retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬
www.biorxiv.org/content/10.1...
Type I interferon signaling instills divergent metastatic phenotypes and immunotherapy responses
Metastatic colonization of distant tissues is responsible for most cancer deaths, yet while this colonization is typically preceded by lymph node (LN) metastasis, the clonal and functional relationshi...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · 15d
Also tomorrow from #PreprintHub1 Shelley Herbrich from MD Anderson will present a #preprint from @LHooperLab on how the gut microbiota regulates intestinal T cell development.

www.biorxiv.org/content/10.1...
The gut microbiota directs vitamin A flux to regulate intestinal T cell development
The intestinal microbiota shapes adaptive immunity, but the mechanisms remain incompletely defined. Here, we show that the microbiota initiates the movement of retinoids—dietary vitamin A derivatives ...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · 15d
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.

www.biorxiv.org/content/10.1...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · 16d
Tomorrow in #PreprintHub2,
@alisaiakupova.bsky.social from
‪@mdc-berlin.bsky.social‬ will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens
Oral tolerance represents a hallmark of intestinal mucosal immunity to prevent inflammatory responses to harmless natural antigens, such as dietary components or commensal organisms. However, the unde...
www.researchsquare.com
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Reposted by Preprint Club - Immunology
theonlylabever.bsky.social
Arthur Mortha @theonlylabever.bsky.social · Jul 17
pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here -> ‪
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social
Regulation of inflammatory responses by pH-dependent transcriptional condensates
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically disordered region. Inflammation-associated acidification triggers a pH-dependent switch in transcriptional...
www.cell.com
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jul 9
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erin-mccaffrey.bsky.social
Erin McCaffrey, PhD @erin-mccaffrey.bsky.social · Jul 8
Thank you to @amitava-bio.bsky.social and Thomas Weichhart for this really nice summary of our preprint! www.nature.com/articles/s41...
Spatial immunometabolic zonation in tuberculosis granulomas - Nature Reviews Immunology
A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.
www.nature.com
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Reposted by Preprint Club - Immunology
weichhartlab.bsky.social
Weichhart Lab @weichhartlab.bsky.social · Jul 8
Amitava Sinha via the @preprintclub.bsky.social‬ wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...
Spatial immunometabolic zonation in tuberculosis granulomas - Nature Reviews Immunology
A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.
www.nature.com
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Reposted by Preprint Club - Immunology
natrevimmunol.nature.com
Nature Reviews Immunology @natrevimmunol.nature.com · Jul 3
Another Journal Club article from @preprintclub.bsky.social -
Mehdi Chaib and James Allison @mdanderson.bsky.social report on @biorxiv-immuno.bsky.social preprint by Han et al. that describes a mechanism by which metastatic tumours secure iron in the bone marrow
#immunosky #cancersky
rdcu.be/euBTD
Tumour cells mimic erythroblasts to hijack iron from bone marrow macrophages
Nature Reviews Immunology - A preprint by Han et al. reports that tumour cells acquire iron in the bone marrow through phenotypic mimicry of erythroblasts, which promotes metastasis and leads to...
rdcu.be
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jul 2
Take a look at our feedback 👉👈

www.preprintclub.com/preprint-rev...
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jul 2
This semester’s #preprinthub2 club, led by Carolina Mangana & Alex Deltedesco has concluded with a #preprint on how human chronic inflammation is orchestrated by spatially restricted inflammation-activated #DCs. 🎻🫨🚧 #immunosky

www.biorxiv.org/content/10.1...
Human chronic inflammation is orchestrated by spatially restricted inflammation-activated Dendritic cells
Dendritic cells (DCs) form coordinated networks that orchestrate inflammatory responses across tissues. Upon activation, conventional dendritic cells (DCs) undergo changes in their transcriptome, phen...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 30
Happy to share with you another excellent preprint highlight. #immunosky
natrevimmunol.nature.com
Nature Reviews Immunology @natrevimmunol.nature.com · Jun 30
NEW Journal Club article from @boyantsankovsci.bsky.social & Dana Philpott @preprintclub.bsky.social highlights a @biorxiv-immuno.bsky.social paper by Srivastava et al. that identifies a previously unknown C19S-modified insulin neoantigen.
rdcu.be/et76Z
Insulin neoantigen elicits memory T cell activation in diabetes
Nature Reviews Immunology - A preprint by Srivastava et al. reports that C19S modification of insulin, which occurs in response to a stressed microenvironment, promotes pro-inflammatory T cell...
rdcu.be
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 27
The Preprint club community is growing! Take a look if you’re interested in #genomics.
genomicspc.bsky.social
Genomics Preprint Club @genomicspc.bsky.social · Jun 25
📣 Hello Bluesky! We’re hosting our June Genomics Preprint Club meeting this Friday, June 27 from 3–4pm EST!

📩 Contact us to join!

🗣️ Presenters:
- Krzysiek Gogolewski: www.medrxiv.org/content/10.1...
- Arnav Wadhawan: www.medrxiv.org/content/10.1...
Informational flyer for next GPC meeting on Friday, June 27 from 3-4pm EST.
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 24
Check out our feedback on this #preprint 📚 📚📚

www.preprintclub.com/preprint-rev...
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 24
In our Wednesday #DoubleFeatureEvent Toronto’s own Arthur Mortha will present a #preprint from @xuzhoulab.bsky.social about the role of pH in environment-dependent control of #inflammation. 🔥🔥🔥

www.biorxiv.org/content/10.1...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 24
Tomorrow, in #PreprintClubHub1 MD Anderson’s Tiantian Zhou will present a #preprint about the way AI-guided CAR designs and AKT3 degradation can synergize to enhance bispecific and trispecific CAR-T cell persistence and overcome #antigen escape. 💻 3️⃣ 🚗

www.biorxiv.org/content/10.1...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 24
Today, in #preprinthub2 Amitava Sinha will present a #preprint from Angelo lab @stanfordmedicine.bsky.social on how the immunometabolic topography of TB granulomas governs cellular organization and bacterial control. 🦠🚦🙊 #immunosky

www.biorxiv.org/content/10.1...
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 17
In our Wednesday #DoubleFeatureEvent Oxford’s own Meghna Shajil will present a #preprint about how hormetic elevation of taurine restrains #inflammaging by deactivation of the NLRP3 inflammasome. 🐂 🧓 3️⃣

www.biorxiv.org/content/10.1...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 17
Tomorrow, in #PreprintClubHub1 Mount Sinai’s own Yu-Chan Chih will present a #preprint about redirecting cytomegalovirus immunity against pancreatic cancer for immunotherapy. ⤴️🫧🦀

www.biorxiv.org/content/10.1...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 17
Today, Michelle Montoya from @uvaimmunology.bsky.social will present a #preprint on how Serpine1 plays a critical role in #Th17 cell differentiation and #psoriasis pathogenesis. 🐭🙌☝️

www.biorxiv.org/content/10.1...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 10
Today, in #preprinthub2 @cleeterichter.bsky.social will lead a discussion of a #preprint from @santoshvardhana.bsky.social @mskcancercenter.bsky.social on MEK-dependent bioenergetic demand driving terminal CD8+ T cell exhaustion. 🫩🍰💥 #immunosky

www.biorxiv.org/content/10.1...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 10
Check out our feedback on this #preprint 📚 📚📚

www.preprintclub.com/preprint-rev...
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 10
Tomorrow, in #PreprintClubHub1 Toronto’s own Sai Chung will present a #preprint about the way liver transplant rejection features #memory cell priming, spatially differentiated #networks and novel drug #targets. 🤔 📶 🎯

www.biorxiv.org/content/10.1...
Liver transplant rejection features memory cell priming, spatially differentiated networks and novel drug targets
Acute T-cell-mediated transplant rejection, the earliest contributor to immunological graft failure responds variably to T-cell suppression. Early rejection can co-exist with donor-specific antibodies...
www.biorxiv.org
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preprintclub.bsky.social
Preprint Club - Immunology @preprintclub.bsky.social · Jun 3
Check out our feedback on this #preprint 📚 📚📚

www.preprintclub.com/preprint-rev...
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