Lightnews — Scholar-powered news

Reposted by Arthur Mortha

Hepworth Lab @hepworth-lab.bsky.social · Sep 8

New Postdoc position as part of the recently awarded MRC Core in Exposome Immunology, led by Jo Konkel here @lydiabeckeriii.bsky.social. Job ad and more info below:
www.jobs.manchester.ac.uk/Job/JobDetai...

www.bmh.manchester.ac.uk/research/ins...

Research Associate in MRC CoRE in Exposome Immunology (Defining Acute and Chronic Mucosal Responses to Pollution Exposure):Oxford Road

Project Title: Defining Acute and Chronic Mucosal Responses to Pollution Exposure

www.jobs.manchester.ac.uk

13 12

Arthur Mortha @theonlylabever.bsky.social · Sep 8

This one is going to be amazing! The 6th International Conference on Innate Lymphoid Cells.
ilc6vancouver.com
Mark your calendars, tell your friends and share widely please. 😘
#immunosky #2026ILC6 #ILC6Vancouver #ILC6

1 3 11

Arthur Mortha @theonlylabever.bsky.social · Sep 5

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice: Cell Reports www.cell.com/cell-reports...

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice

Makhijani et al. investigate the colonic immune landscape in the 5XFAD model, showing a reduction in CXCR4+ antibody-secreting cells and a concomitant increase in brain CXCL12. Dietary intervention wi...

www.cell.com

5

Reposted by Arthur Mortha

The Buck Institute for Research on Aging @buckinstitute.org · Aug 29

Is brain/gut axis a superhighway for immune response to #Alzheimers? Study in @cellpress.bsky.social shows immune cells use that route in mouse models. Feeding animals high fiber diet reduced AD-related frailty. Congrats Dr. Winer, Dr. Makhijani, & Dr. Andersen
www.buckinstitute.org/news/the-gut...

The gut immune system is altered in mouse model of Alzheimer’s, providing a new target for therapeutics

Feeding the animals a high fiber diet reduced Alzheimer’s-related frailty including tremor.

www.buckinstitute.org

2 4

Reposted by Arthur Mortha

Dr. Lisa Reynolds @drlarey.bsky.social · Jul 16

In our latest work we've explored associations between the fecal bile acid pool and helminth infection status in school aged children in Uganda. Have a read and see what we found!

1 4 10

Arthur Mortha @theonlylabever.bsky.social · Jul 17

pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here -> ‪
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social

Regulation of inflammatory responses by pH-dependent transcriptional condensates

BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically disordered region. Inflammation-associated acidification triggers a pH-dependent switch in transcriptional...

www.cell.com

1 4 7

Arthur Mortha @theonlylabever.bsky.social · Jul 4

HBD.

2

Arthur Mortha @theonlylabever.bsky.social · Jul 2

Happy 🇨🇦 day! 😘

2

Arthur Mortha @theonlylabever.bsky.social · Jun 30

www.nature.com/articles/d41...

Single-celled organisms set for greater role in gut health

Long cast as villains, some protists, such as Blastocystis, are potentially beneficial to human health.

www.nature.com

1 5

Reposted by Arthur Mortha

John Rubinstein @johnrubinstein.bsky.social · May 31

🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...

2026 Canada Excellence Research Chair Opportunities | Research & Innovation

research.utoronto.ca

1 45 37

Reposted by Arthur Mortha

King Lab at McGill University @ikinglab.bsky.social · Jun 10

Are you an established PI that studies the human immune system and looking for a change of location? If the answer is yes, #McGill has an amazing opportunity to provide long-term funding at a world class institution. Apply now!!!! Please repost!!! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Canadian Excellence Research Chair (CERC) in Human Immunology

Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

mcgill.wd3.myworkdayjobs.com

1 31 22

Reposted by Arthur Mortha

Tom Hollenstein @tomhollenstein.bsky.social · Jun 5

My Canadian university, Queen's, is offering TWENTY 4-year funded PhDs (40k CAD/yr) for a student of ANY citizenship who has been accepted at a top 100 US university but have had offer rescinded OR are reconsidering offer due to US policy.
Details found here👇

www.queensu.ca/grad-postdoc...

Queen’s Special U.S. Doctoral Recruitment Initiative | School of Graduate Studies and Postdoctoral AffairsDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown...

Queen’s University is a globally engaged, research-intensive institution dedicated to attracting and supporting exceptional PhD students who will significantly advance our research mission.

www.queensu.ca

19 1.4K 1.9K

Reposted by Arthur Mortha

Immunology Podcast @immunologypodcast.com · Jun 4

Why is Dr. Arthur Mortha's lab called @theonlylabever.bsky.social?

Find out in our latest episode, and learn about his work on ILCs and their interactions with the #microbiome!

Listen now: bit.ly/43NmHO0

1 5

Reposted by Arthur Mortha

Gil Kaplan, MD, MPH, FCAHS @gilkaplan.bsky.social · Apr 30

Open-access @nature.com paper from GIVES21 consortium and IOIBD, co-led by Siew Ng and I, funded by @helmsleytrust.bsky.social, reveals the global evolution of IBD across epidemiologic stages. Co–first authors: Dr. Hracs and Dr. Windsor, @ucalgary.bsky.social. www.nature.com/articles/s41...

Global evolution of inflammatory bowel disease across epidemiologic stages - Nature

An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across epidemiologic stages 1 to 3 of...

www.nature.com

5 14

Reposted by Arthur Mortha

Miriam Merad @miriammerad.bsky.social · May 26

25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.

“America First” Will Destroy U.S. Science

The U.S. government has sought to restrict immigration under the “America First” doctrine. These policies severely harm American science by stripping it of talent and eliminating a major driver of its...

www.cell.com

1 55 250

Reposted by Arthur Mortha

Science Magazine @science.org · May 22

In a new #ScienceImmunology Review, researchers discuss how interactions between the nervous and immune systems could impact neurological disorders and allergy-related behaviors like food avoidance. scim.ag/4mpgzE5

The nervous system comprises the CNS and associated sensory nerves (blue) and the autonomic nervous system, which includes sympathetic and parasympathetic nerves (red) and the ENS (purple). The immune system is composed of cells that span the entire body. This includes the meningiocranial immune system, which comprises immune cells important for neural development, brain repair, and brain border protection. Repeated exposure to allergens at mucosal sites (for example, lung, skin, and gut) can trigger local type 2 immunity. Type 2 immune cells signal to neurons across the periphery and brain through cytokines, whereas neurons signal to immune cells via neurotransmitters and neuropeptides. This is not an exhaustive list of cellular players, given that other tissue resident cells (e.g., fibroblasts and glial cells) may also respond to these signals.

2 13 64

Reposted by Arthur Mortha

Theresa Kim, PhD, MS @tyk314.net · May 6

📢📢📢Link here!
The #NIH town hall is tomorrow 1-2 PM ET. I hope someone asks, "When will you comply with the name and email signature block mandates?"

NIH Town Hall - Landing Page

Please check back on the day of the event, May 7, 2025 at 1 PM ET

bit.ly

2 11 17

Reposted by Arthur Mortha

Nature Reviews Immunology @natrevimmunol.nature.com · Apr 23

Robbie Jin & Tracy McGaha discuss a study from @raquelbuj.bsky.social @airdlab.bsky.social reporting that Cdkn2alow tumours impair macrophage phagocytosis by depriving them of zinc

CDKN2Alow tumours mediate immunotherapy resistance by depriving macrophages of zinc - Nature Reviews Immunology

A preprint by Buj et al. reports that Cdkn2alow tumour cells upregulate plasma membrane expression of the zinc importer SLC39A9, which deprives macrophages of zinc and impairs their phagocytic capacit...

www.nature.com

2 3 8

Arthur Mortha @theonlylabever.bsky.social · Apr 23

Congratulations team King! 🥳

1

Reposted by Arthur Mortha

Ivan Zanoni @lozanzi.bsky.social · Apr 19

#WeekendRead! #NotAllFatIsEqual! @lexiong.bsky.social Seillet &co show @cp-immunity.bsky.social that #diet saturated fatty acids rapidly impair (while unsaturated fatty acids favor via lipid droplets) IL22 production by ILC3 supporting dysbiosis & gut permeability, exacerbating inflammation!

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis

Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

www.cell.com

7 19

Reposted by Arthur Mortha

Preprint Club - Immunology @preprintclub.bsky.social · Apr 15

Check out our feedback on this #preprint 📚 📚📚

www.preprintclub.com/preprint-rev...

1 2

Reposted by Arthur Mortha

Preprint Club - Immunology @preprintclub.bsky.social · Apr 15

Tomorrow, in #PreprintClubHub1 MD Anderson’s own Ben Shrank will present a #preprint about a pan-cancer T-cell target atlas for the identification of tumour-specific antigens. 🍳 🎯 🌎

www.biorxiv.org/content/10.1...

A pan-cancer atlas of T cell targets

T-cell-based immunotherapies have revolutionized cancer treatment, yet only a minority of patients respond to these approaches, significantly constrained by the limited knowledge of tumor-specific ant...

www.biorxiv.org

1 2

Reposted by Arthur Mortha

Preprint Club - Immunology @preprintclub.bsky.social · Apr 15

In our Wednesday #DoubleFeatureEvent, Toronto’s Madhieh Golzari will present a #preprint about how maternal immune activation imprints a regulatory #T-cell deficiency that drives an autism-like phenotype in offspring. 🤰🤰🤰

www.biorxiv.org/content/10.1...

Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotype

Maternal immune activation (MIA) triggers an IL-17-driven autism spectrum disorder (ASD) in mouse and human offspring. While regulatory T cells (Tregs) regulate Th17 cells, their involvement in MIA an...

www.biorxiv.org

1 3

Reposted by Arthur Mortha

Jim Johnson 🇨🇦 @jimjohnsonsci.bsky.social · Apr 4

www.nature.com/naturecareer... UBC LSI Job!!

Assistant Professor (tenure track) – Chromatin, Epigenetics - Vancouver, British Columbia (CA) job with The University of British Columbia (UBC) | 12837841

Assistant Professor (tenure track) - Chromatin Regulation, Genetic Regulatory Mechanisms, Epigenetics, Epigenomics

www.nature.com

36 32

Reposted by Arthur Mortha

Preprint Club - Immunology @preprintclub.bsky.social · Apr 1

Tomorrow, in #PreprintClubHub1 Toronto’s Miki Gams will present a #preprint from @BusadaLab about how androgen signalling in type 2 innate lymphoid cells drives sex differences in Helicobacter-induced #gastric inflammation and atrophy. 💪🫄🦠

www.biorxiv.org/content/10.1...

Androgen Signaling in Type 2 Innate Lymphoid Cells Drives Sex Differences in Helicobacter-Induced Gastric Inflammation and Atrophy

Background & Aims: Gastric cancer is the fifth most common cancer worldwide. Men are disproportionately affected by gastric cancer, which ranks as the fourth most common cancer in men compared to eigh...

www.biorxiv.org

1 3