Window Screen

xkcd.com/3151/

Truly chuffed for our fearless food physicists @mpipks.bsky.social + collabs from AT @istaresearch.bsky.social, IT & ES who won this year’s Ig Nobel - the #NobelPrize of hearts❤️for cracking the science of perfect pasta !🍝Kudos to all for intrepidly consuming lots of cheese in the name of science!😋

Biology Department

xkcd.com/3140/

Duke is recruiting a tenure-track Assistant Professor in AI/ML for Biology—joint Discovery AI Initiative × Cell Biology Search. Building models for protein design, single-cell/spatial omics, imaging, proteomics, genomics? Apply: academicjobsonline.org/ajo/jobs/30509
#hiring #AIforBio #CompBio

Thank you to my two amazing mentors @bagnatlab.bsky.social, @ditalialab.bsky.social and co-author James Norman. Excited to hear your thoughts!

(8/n) To decode the circuit components, we use genetics to show the increasing expression of Egf ligand near the bifurcation. We propose negative feedback required for the oscillations is provided by the transcription of spry and dusp

(7/n) We show that the first cycle is slower and built a simple mathematical model to understand how an oscillatory circuit can generate different frequencies following a bifurcation

(6/n) We found interesting features of the oscillations. Remarkably, oscillators are very synchronized. We map emergence of synchronicity and the first oscillation cycle

(5/n) This provides an example of how biology uses oscillators as timers to generate periodic patterns!

(4/n) 4) These oscillations result in periodic increases in the expression of segmentation pathway genes, allowing induction and maturation of cells to build segments

(3/n) We found that the notochord cells display intra-cellular Erk oscillations of around 10 hours

(2/n) We wanted to investigate what controlled the pace at which segmentation proceeded

(1/n) The zebrafish notochord slowly builds the vertebral column of the spine over ~ 2 weeks through a process of molecular segmentation (=division of tissue into units)

Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below

Thank you for the support! @febsletters.bsky.social

5 dynamical systems concepts every developmental biologist needs to know! This came out of the 2023 Morphogenesis Program. @pauformosa.bsky.social ‪@perez-carrasco.bsky.social‬
journals.biologists.com/dev/article/...

Please spread the word!
We are looking for postdoc(s) interested in quantitative problems in Development and Regeneration. Previous experience in quantitative biology is not required. We will support you and provide a great training environment if you are committed to learn new things.