Ruben Dörfel
@rdoerfel.bsky.social
Interested in aging, neuroimaging, and machine learning.
PhD student at Karolinska Institutet, NRU Rigshospitalet, and DIKU UCPH
PhD student at Karolinska Institutet, NRU Rigshospitalet, and DIKU UCPH
Pinned
Ruben Dörfel
@rdoerfel.bsky.social
· Mar 18
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Predicting brain age from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. Ideally, as a clinically valid biomarker, brain age should indicate...
www.medrxiv.org
I'm happy to share our latest pre-print on assessing the clinical validity of brain age as a biomarker of aging-related diseases and structural and memory decline in the brain!
www.medrxiv.org/content/10.1...
(1/7)
www.medrxiv.org/content/10.1...
(1/7)
Interesting paper showing that "much inter-individual differences in neuroanatomical volumes almost exclusively reflects stable differences between individuals" before 60 years, rather than age-related changes.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes
Differences in the volumes of brain structures between individuals are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains u...
www.biorxiv.org
November 7, 2025 at 9:38 AM
Interesting paper showing that "much inter-individual differences in neuroanatomical volumes almost exclusively reflects stable differences between individuals" before 60 years, rather than age-related changes.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Pretty good perspective paper on brain age in kids:
www.nature.com/articles/s41...
I think a lot of the points / issues are relevant to the entire field, not only brain age in younger populations.
www.nature.com/articles/s41...
I think a lot of the points / issues are relevant to the entire field, not only brain age in younger populations.
Current challenges and future directions for brain age prediction in children and adolescents - Nature Communications
This Perspective outlines how brain-age prediction models are increasingly applied to child and adolescent populations and examines the specific challenges this entails. It offers practical recommenda...
www.nature.com
November 6, 2025 at 10:53 AM
Pretty good perspective paper on brain age in kids:
www.nature.com/articles/s41...
I think a lot of the points / issues are relevant to the entire field, not only brain age in younger populations.
www.nature.com/articles/s41...
I think a lot of the points / issues are relevant to the entire field, not only brain age in younger populations.
Pretty cool development! New high-res neuro-PET scanner. Look at the cortical ribbon and the small subcortical regions and nuclei!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT - European Journal of Nuclear Medicine and Molecular Imaging
Purpose Current brain-dedicated positron emission tomography (PET) systems (e.g., the High-Resolution Research Tomograph, HRRT) are unable to accurately and precisely measure pharmacologically-specifi...
link.springer.com
November 6, 2025 at 10:09 AM
Pretty cool development! New high-res neuro-PET scanner. Look at the cortical ribbon and the small subcortical regions and nuclei!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Ruben Dörfel
Registration opened just 1 week ago and we already have 390+ registrations from more than 25 countries and presenting 85+ papers! We are very excited to see the community support the #EurIPS initiative and look forward to meeting you all in Copenhagen 🙌
October 8, 2025 at 12:11 PM
Registration opened just 1 week ago and we already have 390+ registrations from more than 25 countries and presenting 85+ papers! We are very excited to see the community support the #EurIPS initiative and look forward to meeting you all in Copenhagen 🙌
Reposted by Ruben Dörfel
Congratulations to everyone who got their @neuripsconf.bsky.social papers accepted 🎉🎉🎉
At #EurIPS we are looking forward to welcoming presentations of all accepted NeurIPS papers, including a new “Salon des Refusés” track for papers which were rejected due to space constraints!
At #EurIPS we are looking forward to welcoming presentations of all accepted NeurIPS papers, including a new “Salon des Refusés” track for papers which were rejected due to space constraints!
September 19, 2025 at 9:13 AM
Congratulations to everyone who got their @neuripsconf.bsky.social papers accepted 🎉🎉🎉
At #EurIPS we are looking forward to welcoming presentations of all accepted NeurIPS papers, including a new “Salon des Refusés” track for papers which were rejected due to space constraints!
At #EurIPS we are looking forward to welcoming presentations of all accepted NeurIPS papers, including a new “Salon des Refusés” track for papers which were rejected due to space constraints!
Reposted by Ruben Dörfel
In short, world-class research from NeurIPS accessible in Europe.
EurIPS takes place over 3 days + 2 workshop days, at the same time as NeurIPS in San Diego.
Follow this account for more updates, and see you in wonderful Copenhagen 📅
eurips.cc
EurIPS takes place over 3 days + 2 workshop days, at the same time as NeurIPS in San Diego.
Follow this account for more updates, and see you in wonderful Copenhagen 📅
eurips.cc
EurIPS Copenhagen 2025 - A NeurIPS-endorsed conference in Europe
A NeurIPS-endorsed conference in Europe held in Copenhagen, Denmark
eurips.cc
August 27, 2025 at 6:41 AM
In short, world-class research from NeurIPS accessible in Europe.
EurIPS takes place over 3 days + 2 workshop days, at the same time as NeurIPS in San Diego.
Follow this account for more updates, and see you in wonderful Copenhagen 📅
eurips.cc
EurIPS takes place over 3 days + 2 workshop days, at the same time as NeurIPS in San Diego.
Follow this account for more updates, and see you in wonderful Copenhagen 📅
eurips.cc
Interesting paper by Vidal-Piñeiro et al. doi.org/10.1162/imag....
They show that "Increasing the follow-up time was associated with a substantial increase in longitudinal reliability, while the impact of increasing the number of observations was comparatively minor."
They show that "Increasing the follow-up time was associated with a substantial increase in longitudinal reliability, while the impact of increasing the number of observations was comparatively minor."
Reliability of structural brain change in cognitively healthy adult samples
Abstract. In neuroimaging research, tracking individuals over time is key to understanding the interplay between brain changes and genetic, environmental, or cognitive factors across the lifespan. Yet...
doi.org
August 6, 2025 at 8:42 AM
Interesting paper by Vidal-Piñeiro et al. doi.org/10.1162/imag....
They show that "Increasing the follow-up time was associated with a substantial increase in longitudinal reliability, while the impact of increasing the number of observations was comparatively minor."
They show that "Increasing the follow-up time was associated with a substantial increase in longitudinal reliability, while the impact of increasing the number of observations was comparatively minor."
Reposted by Ruben Dörfel
EurIPS includes a call for both Workshops and Affinity Workshops!
We look forward to making #EurIPS a diverse and inclusive event with you.
The submission deadlines are August 22nd, AoE.
More information at:
eurips.cc/call-for-wor...
eurips.cc/call-for-aff...
We look forward to making #EurIPS a diverse and inclusive event with you.
The submission deadlines are August 22nd, AoE.
More information at:
eurips.cc/call-for-wor...
eurips.cc/call-for-aff...
July 28, 2025 at 8:51 AM
EurIPS includes a call for both Workshops and Affinity Workshops!
We look forward to making #EurIPS a diverse and inclusive event with you.
The submission deadlines are August 22nd, AoE.
More information at:
eurips.cc/call-for-wor...
eurips.cc/call-for-aff...
We look forward to making #EurIPS a diverse and inclusive event with you.
The submission deadlines are August 22nd, AoE.
More information at:
eurips.cc/call-for-wor...
eurips.cc/call-for-aff...
Reposted by Ruben Dörfel
Updated my Python project setup guide - originally created for my students but might be useful for other researchers and data scientists. Covers pyenv, poetry, git, and project structure best practices. Open to suggestions for improvements.
rdoerfel.github.io/blog/2025/En...
rdoerfel.github.io/blog/2025/En...
Setting up a Scientific Python Project from Scratch | Ruben P. Dörfel
A guide to set up a scientific Python project from scratch, covering version control, virtual environments, and project structure.
rdoerfel.github.io
July 10, 2025 at 2:27 PM
Updated my Python project setup guide - originally created for my students but might be useful for other researchers and data scientists. Covers pyenv, poetry, git, and project structure best practices. Open to suggestions for improvements.
rdoerfel.github.io/blog/2025/En...
rdoerfel.github.io/blog/2025/En...
Updated my Python project setup guide - originally created for my students but might be useful for other researchers and data scientists. Covers pyenv, poetry, git, and project structure best practices. Open to suggestions for improvements.
rdoerfel.github.io/blog/2025/En...
rdoerfel.github.io/blog/2025/En...
Setting up a Scientific Python Project from Scratch | Ruben P. Dörfel
A guide to set up a scientific Python project from scratch, covering version control, virtual environments, and project structure.
rdoerfel.github.io
July 10, 2025 at 2:27 PM
Updated my Python project setup guide - originally created for my students but might be useful for other researchers and data scientists. Covers pyenv, poetry, git, and project structure best practices. Open to suggestions for improvements.
rdoerfel.github.io/blog/2025/En...
rdoerfel.github.io/blog/2025/En...
Reposted by Ruben Dörfel
New article out at Human Brain Mapping showing that brain age ≠ brain ageing (estimating brain age on all available features).
This is not the only article showcasing this. Brain age is still useful, but be careful about the longitudinal claims.
doi.org/10.1002/hbm....
This is not the only article showcasing this. Brain age is still useful, but be careful about the longitudinal claims.
doi.org/10.1002/hbm....
April 16, 2025 at 10:35 AM
New article out at Human Brain Mapping showing that brain age ≠ brain ageing (estimating brain age on all available features).
This is not the only article showcasing this. Brain age is still useful, but be careful about the longitudinal claims.
doi.org/10.1002/hbm....
This is not the only article showcasing this. Brain age is still useful, but be careful about the longitudinal claims.
doi.org/10.1002/hbm....
Reposted by Ruben Dörfel
FOMO25 accepted at #MICCAI2025! 🚀
Excited to announce the first challenge at MICCAI focusing on the development of self-supervised pretraining of foundation models for brain MRI! 🧠
With access to a large-scale dataset, codebase, cash prices and multiple tracks.
Read more ⬇️
Excited to announce the first challenge at MICCAI focusing on the development of self-supervised pretraining of foundation models for brain MRI! 🧠
With access to a large-scale dataset, codebase, cash prices and multiple tracks.
Read more ⬇️
April 22, 2025 at 1:03 PM
FOMO25 accepted at #MICCAI2025! 🚀
Excited to announce the first challenge at MICCAI focusing on the development of self-supervised pretraining of foundation models for brain MRI! 🧠
With access to a large-scale dataset, codebase, cash prices and multiple tracks.
Read more ⬇️
Excited to announce the first challenge at MICCAI focusing on the development of self-supervised pretraining of foundation models for brain MRI! 🧠
With access to a large-scale dataset, codebase, cash prices and multiple tracks.
Read more ⬇️
Reposted by Ruben Dörfel
I'm happy to share our latest pre-print on assessing the clinical validity of brain age as a biomarker of aging-related diseases and structural and memory decline in the brain!
www.medrxiv.org/content/10.1...
(1/7)
www.medrxiv.org/content/10.1...
(1/7)
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Predicting brain age from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. Ideally, as a clinically valid biomarker, brain age should indicate...
www.medrxiv.org
March 18, 2025 at 3:33 PM
I'm happy to share our latest pre-print on assessing the clinical validity of brain age as a biomarker of aging-related diseases and structural and memory decline in the brain!
www.medrxiv.org/content/10.1...
(1/7)
www.medrxiv.org/content/10.1...
(1/7)
I'm happy to share our latest pre-print on assessing the clinical validity of brain age as a biomarker of aging-related diseases and structural and memory decline in the brain!
www.medrxiv.org/content/10.1...
(1/7)
www.medrxiv.org/content/10.1...
(1/7)
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Predicting brain age from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. Ideally, as a clinically valid biomarker, brain age should indicate...
www.medrxiv.org
March 18, 2025 at 3:33 PM
I'm happy to share our latest pre-print on assessing the clinical validity of brain age as a biomarker of aging-related diseases and structural and memory decline in the brain!
www.medrxiv.org/content/10.1...
(1/7)
www.medrxiv.org/content/10.1...
(1/7)
Reposted by Ruben Dörfel
Remember the whole #narps (www.narps.info) splash?
We are very interested in how to utilize the multiverse in neuroimaging. Because no matter how we process biological data, if we do something reasonable, the underlying results shouldn't change too much - because biology doesn't change, right?
We are very interested in how to utilize the multiverse in neuroimaging. Because no matter how we process biological data, if we do something reasonable, the underlying results shouldn't change too much - because biology doesn't change, right?
March 17, 2025 at 9:15 AM
Remember the whole #narps (www.narps.info) splash?
We are very interested in how to utilize the multiverse in neuroimaging. Because no matter how we process biological data, if we do something reasonable, the underlying results shouldn't change too much - because biology doesn't change, right?
We are very interested in how to utilize the multiverse in neuroimaging. Because no matter how we process biological data, if we do something reasonable, the underlying results shouldn't change too much - because biology doesn't change, right?
Reposted by Ruben Dörfel
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Led by @rdoerfel.bsky.social
doi.org/10.1101/2025...
Led by @rdoerfel.bsky.social
doi.org/10.1101/2025...
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Predicting brain age from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. Ideally, as a clinically valid biomarker, brain age should indicate...
doi.org
March 15, 2025 at 10:04 AM
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Led by @rdoerfel.bsky.social
doi.org/10.1101/2025...
Led by @rdoerfel.bsky.social
doi.org/10.1101/2025...
Reposted by Ruben Dörfel
Hier das Fazit - aber wie immer: So eine Grafik erzählt nicht die ganze Geschichte, schaut rein und guckt die Quellen an - überprüft gern alles selbst.
February 19, 2025 at 12:24 PM
Hier das Fazit - aber wie immer: So eine Grafik erzählt nicht die ganze Geschichte, schaut rein und guckt die Quellen an - überprüft gern alles selbst.
Reposted by Ruben Dörfel
Great review by Svensson et al. on how to systematically evaluate geroprotective interventions in humans!
link.springer.com/article/10.1...
1/3
link.springer.com/article/10.1...
1/3
In vivo medical imaging for assessing geroprotective interventions in humans - GeroScience
There is a growing interest in developing drugs with a general geroprotective effect, aimed at slowing down aging. Several compounds have been shown to increase the lifespan and reduce the incidence o...
link.springer.com
February 14, 2025 at 9:32 AM
Great review by Svensson et al. on how to systematically evaluate geroprotective interventions in humans!
link.springer.com/article/10.1...
1/3
link.springer.com/article/10.1...
1/3
Great review by Svensson et al. on how to systematically evaluate geroprotective interventions in humans!
link.springer.com/article/10.1...
1/3
link.springer.com/article/10.1...
1/3
In vivo medical imaging for assessing geroprotective interventions in humans - GeroScience
There is a growing interest in developing drugs with a general geroprotective effect, aimed at slowing down aging. Several compounds have been shown to increase the lifespan and reduce the incidence o...
link.springer.com
February 14, 2025 at 9:32 AM
Great review by Svensson et al. on how to systematically evaluate geroprotective interventions in humans!
link.springer.com/article/10.1...
1/3
link.springer.com/article/10.1...
1/3
Reposted by Ruben Dörfel
Health pseudoscience in a nutshell:
A non-expert uses in vitro/animal studies to infer a revolutionary understanding of a disease, then sells a dietary supplement whose effectiveness likewise rests on preliminary studies done in cells in culture flasks.
Every. Frickin'. Time.
A non-expert uses in vitro/animal studies to infer a revolutionary understanding of a disease, then sells a dietary supplement whose effectiveness likewise rests on preliminary studies done in cells in culture flasks.
Every. Frickin'. Time.
February 10, 2025 at 6:51 PM
Health pseudoscience in a nutshell:
A non-expert uses in vitro/animal studies to infer a revolutionary understanding of a disease, then sells a dietary supplement whose effectiveness likewise rests on preliminary studies done in cells in culture flasks.
Every. Frickin'. Time.
A non-expert uses in vitro/animal studies to infer a revolutionary understanding of a disease, then sells a dietary supplement whose effectiveness likewise rests on preliminary studies done in cells in culture flasks.
Every. Frickin'. Time.
An amazing educational piece on the evolution of aging, and why natural selection does NOT favor longevity:
www.youtube.com/watch?v=1_Jb...
www.youtube.com/watch?v=1_Jb...
Simulating the Evolution of Aging
YouTube video by Primer
www.youtube.com
February 5, 2025 at 9:53 AM
An amazing educational piece on the evolution of aging, and why natural selection does NOT favor longevity:
www.youtube.com/watch?v=1_Jb...
www.youtube.com/watch?v=1_Jb...
Reposted by Ruben Dörfel
📢 Call for Papers: Fairness of AI in Medical Imaging (MELBA Journal Special Issue)
We invite submissions for our special issue on fairness in AI for medical imaging in MELBA, an open-access journal at the intersection of machine learning & biomedical imaging.
faimi-workshop.github.io/2024-melba/
We invite submissions for our special issue on fairness in AI for medical imaging in MELBA, an open-access journal at the intersection of machine learning & biomedical imaging.
faimi-workshop.github.io/2024-melba/
Fairness of AI in Medical Imaging
MELBA Special Issue
faimi-workshop.github.io
February 3, 2025 at 9:36 PM
📢 Call for Papers: Fairness of AI in Medical Imaging (MELBA Journal Special Issue)
We invite submissions for our special issue on fairness in AI for medical imaging in MELBA, an open-access journal at the intersection of machine learning & biomedical imaging.
faimi-workshop.github.io/2024-melba/
We invite submissions for our special issue on fairness in AI for medical imaging in MELBA, an open-access journal at the intersection of machine learning & biomedical imaging.
faimi-workshop.github.io/2024-melba/
Reposted by Ruben Dörfel
AfD Sachsen: Sogar gerichtlich bestätigt gesichert rechtsextrem und verfassungsfeindlich
CDU Sachsen: Wir sollten die AfD Sachsen jetzt nicht vorverurteilen und sie in Posten wählen oder beim Holocaustgedenken sprechen lassen!
Leute, die AfD Sachsen IST zu verurteilen! Die Ergebnisse sind da!
CDU Sachsen: Wir sollten die AfD Sachsen jetzt nicht vorverurteilen und sie in Posten wählen oder beim Holocaustgedenken sprechen lassen!
Leute, die AfD Sachsen IST zu verurteilen! Die Ergebnisse sind da!
January 24, 2025 at 8:44 AM
AfD Sachsen: Sogar gerichtlich bestätigt gesichert rechtsextrem und verfassungsfeindlich
CDU Sachsen: Wir sollten die AfD Sachsen jetzt nicht vorverurteilen und sie in Posten wählen oder beim Holocaustgedenken sprechen lassen!
Leute, die AfD Sachsen IST zu verurteilen! Die Ergebnisse sind da!
CDU Sachsen: Wir sollten die AfD Sachsen jetzt nicht vorverurteilen und sie in Posten wählen oder beim Holocaustgedenken sprechen lassen!
Leute, die AfD Sachsen IST zu verurteilen! Die Ergebnisse sind da!
If you're looking for something to occupy the final days before the grind begins again, I highly recommend this blog post:
It explains how and when flow matching and diffusion are equivalent, unifying both frameworks so that you can use the best of both worlds!
diffusionflow.github.io
It explains how and when flow matching and diffusion are equivalent, unifying both frameworks so that you can use the best of both worlds!
diffusionflow.github.io
Diffusion Meets Flow Matching
Flow matching and diffusion models are two popular frameworks in generative modeling. Despite seeming similar, there is some confusion in the community about their exact connection. In this post, we a...
diffusionflow.github.io
January 3, 2025 at 10:56 AM
If you're looking for something to occupy the final days before the grind begins again, I highly recommend this blog post:
It explains how and when flow matching and diffusion are equivalent, unifying both frameworks so that you can use the best of both worlds!
diffusionflow.github.io
It explains how and when flow matching and diffusion are equivalent, unifying both frameworks so that you can use the best of both worlds!
diffusionflow.github.io
