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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Aug 12

🚀 Big milestone achieved!

GRAINS-BP trial is officially underway as we’ve randomised our first participant.

Huge thanks to @fzmarques.bsky.social, our collaborators, funders, and PhD student Malindi. 🙌

For more information and recruitment, please check out www.marqueslab.com/trials

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Reposted by Rikeish R Muralitharan MD, PhD

Prof Francine Marques @fzmarques.bsky.social · May 25

Our latest paper is out in Cardiovascular Research

We used a genetics approach to provide human evidence of gut-to-host crosstalk in how blood pressure is regulated

Authors include Leticia Camargo Tavares, @mattsnelson.bsky.social @rikeish.bsky.social

academic.oup.com/cardiovascre...

Rare pathogenic variants in G-protein-coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk

Gut microbial metabolites called short-chain fatty acids (SCFAs) confer protection against cardiovascular disease (CVD) and its primary risk factor, hypert

academic.oup.com

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Reposted by Rikeish R Muralitharan MD, PhD

Prof Francine Marques @fzmarques.bsky.social · May 25

Our review on the gut-heart axis published in Circ Res is now out www.ahajournals.org/doi/10.1161/...

We cover gut #microbiome, 'leaky gut', foods & metabolites, +++

Congratulations @mattsnelson.bsky.social @rikeish.bsky.social and our co-authors 👏

American Heart Association Journals

www.ahajournals.org

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · May 18

🚨Do you have high blood pressure (BP) but not on meds?
Join our clinical study exploring how fibre supplements may lower BP naturally.
✅ Free health checks
$ Compensation for your time
📍 @AlfredHealth VIC
🔬 Ages 18–75
📲 Apply now: [email protected]
#ClinicalTrials #BP

Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · May 18

We addressing the gap in the literature by initiating a #clinical #trial.

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · May 18

Great team effort including Malindi, Vaughan Macefield, Damian Keating, Daniela Carnevale, and @fzmarques.bsky.social.

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · May 18

🧠🦠Can the gut communicate with the brain to regulate BP?

Our latest review explores how microbial metabolites (SCFAs) may regulate BP via the gut–brain axis.
A promising new frontier for hypertension treatment.
📖 Read more: doi.org/10.1042/CS20...

Cross-talk between microbiota–gut–brain axis and blood pressure regulation

Hypertension, or high blood pressure (BP), is a widespread condition affecting one in three adults globally. Despite the availability of treatment options, 50% of hypertensive patients in countries su...

doi.org

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · May 18

@monashuniversity.bsky.social @nhmrc.bsky.social @fzmarques.bsky.social

Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · May 18

🚨 EMCRs in cardiovascular research!

Join our free webinar on the NHMRC Investigator Grant Scheme 🧠

📅 June 3 | 🕥 10:30am–12:00pm ACST
💡 Hear from successful applicants & peer reviewers
🔗 Register now: monash.zoom.us/webinar/regist…#NHMRCR#CardioResearchc#EMCRC#SACVRNR#VicCVRNRN

Note: Since your browser does not support JavaScript, you must press the Continue button once to proceed.

https://monash.zoom.us/webinar/regist…

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Reposted by Rikeish R Muralitharan MD, PhD

Gut Microbiota for Health @gmfhx.bsky.social · Mar 26

Could the connection between the #gutmicrobiome and hypertension pave the way to better management strategies?

New findings in mice provide clues:

Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension | Circulation Research

BACKGROUND: Fermentation of dietary fiber by the gut microbiota leads to the production of metabolites called short-chain fatty acids, which lower blood pressure and exert cardioprotective effects. Short-chain fatty acids activate host signaling responses via the functionally redundant receptors GPR...

www.ahajournals.org

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Reposted by Rikeish R Muralitharan MD, PhD

Eric Topol @erictopol.bsky.social · Mar 13

How a fat in our diet (omega-6 linoleic acid)—a dietary long-chain polyunsaturated fatty acid) has the potential to promote tumor growth www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org

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Reposted by Rikeish R Muralitharan MD, PhD

Prof Francine Marques @fzmarques.bsky.social · Feb 13

Congrats @rikeish.bsky.social for your immunofluorescence image making it to the cover 👏👏👏 www.ahajournals.org/journal/res

Also read the ‘Meet the first author’ and accompanying editorial (thanks @annetkiraboc1.bsky.social 👏👏👏)

Paper and 🧵 👇

www.ahajournals.org/doi/full/10....

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Feb 6

Super excited to join @ahajournals.bsky.social Hypertension as an #ECR editorial assistant!

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Reposted by Rikeish R Muralitharan MD, PhD

Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. @annetkiraboc1.bsky.social · Feb 4

Interesting breakdown by @fzmarques.bluesky.social & @rikeish.bsky.social on how the gut #microbiome shapes #bloodpressure of their paper published in #CircRes.

📝 Blog: www.marqueslab.com/post/underst…
📄 Paper: www.ahajournals.org/doi/10.1161/�#Hypertensionrtension @ahajournals.bsky.social

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Jan 30

Press release: www.monash.edu/news/article...

New link revealed between hypertension and the gut

Monash University researchers have revealed how the gut – and what we eat – regulates high blood pressure, opening the door to more specialised potential new drugs.

www.monash.edu

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Jan 30

Grateful to my mentors @fzmarques.bsky.social Dr Joanne O'Donnell and Charles Mackay who helped guide this work and to all co-authors for the support and funding bodies NHMRC, Heart Foundation Australia, @monashbiol.bsky.social @monashuniversity.bsky.social

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Jan 30

In short, the answer is yes, there is a gene-environment interaction that increases risk for hypertension. My colleague Dr Leticia Tavares has done more work in this area doi.org/10.1101/2024...

Rare pathogenic variants in G-protein coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk

Background: Gut microbial metabolites called short-chain fatty acids (SCFA) confer protective effects against cardiovascular disease and high blood pressure. Proposed mechanisms include anti-inflammat...

doi.org

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Jan 30

Mechanistic studies were performed in an animal model, so we asked ourselves whether these receptors are relevant to human hypertension

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Jan 30

Immune cells and the inflammation are linked to hypertension but direct targeting of immune cells has not been particularly effective. Perhaps we could target these receptors to reduce immune activation instead?

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Jan 30

We show that absence of these receptors leads to higher gut permeability (aka leaky gut) associated with higher inflammation in target organ such as the kidney. We also show that the absence of these receptors in immune cells was sufficient to worsen hypertension.

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Jan 30

We and others have previously shown that SCFA supplementation can reduce BP but underlying mechanisms were unclear. Here we show that SCFA-receptors are protective in hypertension in the Ang II model.

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Jan 30

I am super proud and excited to share my latest publication, out now in @ahajournals.bsky.social (www.ahajournals.org/doi/10.1161/...)

Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension | Circulation Research

BACKGROUND: Fermentation of dietary fiber by the gut microbiota leads to the production of metabolites called short-chain fatty acids, which lower blood pressure and exert cardioprotective effects. Sh...

www.ahajournals.org

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Rikeish R Muralitharan MD, PhD @rikeish.bsky.social · Jan 23

www.science.org/content/arti...

People are bad at reporting what they eat. That’s a problem for dietary research

Studies that use surveys to link dietary patterns to human health may be irredeemably biased, new paper suggests

www.science.org

Reposted by Rikeish R Muralitharan MD, PhD

Eric Topol @erictopol.bsky.social · Jan 23

The impact of a non-industrialized ("Restore") diet plus a key microbe on improving cardiometaboiic health markers and reducing body-wide inflammation, from a randomized trial
www.cell.com/cell/fulltex... @cellpress.bsky.social open-access

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Reposted by Rikeish R Muralitharan MD, PhD

Eric Topol @erictopol.bsky.social · Jan 13

The gut microbiome products and.....
—propensity to eat foods high in sugar
nature.com/articles/s41...
—accelerating cellular senescence
nature.com/articles/s43...

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