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Robert Hermosillo @roberthermosillo.bsky.social · Aug 30

Mapping infant brains with precision today = insights into developmental health tomorrow. Incredible work by @drjuliamoser.bsky.social introduces precision functional mapping for infants. 👶 #Neuroimaging

Julia Moser @drjuliamoser.bsky.social · Aug 29

Is precision functional brain imaging in babies possible? YES! We show this in not one but two new preprints out of WashU and @umn-midb.bsky.social! 1️⃣: www.biorxiv.org/content/10.1... 2️⃣: www.biorxiv.org/content/10.1...
🐣👶🧠

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Reposted by Robert Hermosillo

Julia Moser @drjuliamoser.bsky.social · Aug 29

Is precision functional brain imaging in babies possible? YES! We show this in not one but two new preprints out of WashU and @umn-midb.bsky.social! 1️⃣: www.biorxiv.org/content/10.1... 2️⃣: www.biorxiv.org/content/10.1...
🐣👶🧠

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Robert Hermosillo @roberthermosillo.bsky.social · Aug 25

This might be related to the feelings of joy we observed when stimulating the ventromedial PFC, which is also within the salience network: bsky.app/profile/drda...

Nicole Rust @nicolecrust.bsky.social · Aug 23

Crying and sadness induced by stimulation to L anterior insula (a human case study). How remarkable.

pubmed.ncbi.nlm.nih.gov/33511338/

During stimulation, the patient was asked to count from 1 to 20
and was stimulated initially at 1 mA, without any change in her
mental status. However when she was serially up ramped to
5 mA, and while counting out loud from 1-20, she became ‘‘emo-
tional” and ‘‘teary eyed” and mentioned that she felt a change in
her emotional status to becoming ‘‘sad” and had a ‘‘sad tear”, but
was able to finish her counting and did not experience any motor
deficits. She subsequently asked for a tissue and wiped her tears
with it. After the stimulation was stopped, she immediately
returned back to her normal state. Time locked sorrowful crying
with lacrimation was again reproducible with a repeat stimulation
of the same electrode pair at 5 mA. The stimulation was not
repeated after, as the patient was emotionally distraught and
requested the procedure to be stopped. This is shown in the video
in the supplemental digital content.

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Reposted by Robert Hermosillo

Damien Fair @drdamienfair.bsky.social · Aug 20

👇🏾👇🏾👇🏾👇🏾

New Scientist @newscientist.com · Aug 20

A man who had severe depression for more than 30 years has "experienced joy" after undergoing bespoke brain stimulation.

Brain implant lets man 'experience joy' for the first time in decades

A device that has been likened to a pacemaker for the brain has given a man with severe depression great relief

www.newscientist.com

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Reposted by Robert Hermosillo

Alex Fornito @alexfornito.bsky.social · Aug 17

Interested in Network hubs, cortical hierarchies, and gradients? Ever wonder where they come from? Check our latest review, where we cover different approaches to mapping hubs, models for their evolution, and mechanisms for how they develop:

osf.io/preprints/os...

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Reposted by Robert Hermosillo

Rick Betzel @richardfbetzel.bsky.social · Aug 10

Personalized Adaptive Cortical Electro-stimulation (PACE) in Treatment-Resistant Depression

Punchline: PERSONALIZED network neuroscience works.

*Easily* the most important paper I’ve been part of.

Read the manuscript for details. Watch the movies for *amazing* testimonial.

1/2

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Reposted by Robert Hermosillo

Julia Moser @drjuliamoser.bsky.social · Aug 10

What an amazing demonstration of why Precision Functional Mapping matters 🧠It’s been an honor to support the team in this huge endeavor!

Damien Fair @drdamienfair.bsky.social · Aug 10

I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...

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Reposted by Robert Hermosillo

ziad-nahas.bsky.social @ziad-nahas.bsky.social · Aug 10

Then we turned on his minimally invasive brain pace-maker and this happened. Thirty months later, his depression remains in full remission.
lnkd.in/gb4WdZMQ
lnkd.in/gFZV4zBp
#Neuroscience #MentalHealthInnovation #FunctionalMRI #PrecisionMedicine #DepressionResearch #PACE #BrainStimulation

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Reposted by Robert Hermosillo

David Darrow @drdaviddarrow.bsky.social · Aug 10

This is the future. The reality of biological #psychiatry. We listen to the patient, create a personalized map of their brain, use algorithms to disrupt stuck networks, and adapt the stimulation over time while continuing our quest to understand those networks.

Damien Fair @drdamienfair.bsky.social · Aug 10

Now with PFM, prior cortical stim work by @ziad-nahas.bsky.social for depression could be patient specific.

We developed the end-to-end minimally invasive PACE used by @drdaviddarrow.bsky.social to place electrodes directly on Mike's salience, default, fronto-parietal, and action mode networks.

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Robert Hermosillo @roberthermosillo.bsky.social · Aug 11

When nothing worked, this did. Precision functional mapping is here for treatment-resistant depression. This is what hope looks like. 💡

Damien Fair @drdamienfair.bsky.social · Aug 10

I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...

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Robert Hermosillo @roberthermosillo.bsky.social · Jul 22

This is so cool! I don't think I've ever seen a face projected onto the cortical surface like that. I can't wait to try out the code!

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Robert Hermosillo @roberthermosillo.bsky.social · Jul 16

"The [number of NSF trainees] supported would drop from 95,700 undergrads, grad students, and postdocs during this FY to 21,400." Not only will this eviscerate the future scientific workforce, but science will grind to a halt. Trainees are the workhorses of research.
www.science.org/content/arti...

‘It’s a nightmare.’ U.S. funding cuts threaten academic science jobs at all levels

“There is a lot of pressure to essentially leave the country or not pursue research,” one Ph.D. student says

www.science.org

Robert Hermosillo @roberthermosillo.bsky.social · Jul 2

I can't wait to hear more about this!

Robert Hermosillo @roberthermosillo.bsky.social · Jun 26

Excited to be a part of this team working on the next generation of pain treatment led by and Alexander Herman and @drdaviddarrow.bsky.social and @drdamienfair.bsky.social

Damien Fair @drdamienfair.bsky.social · Jun 26

Alert!!!!

“An Action Networks Model for Pain”

We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.

👉 thread below 🧵

osf.io/preprints/ps...

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Robert Hermosillo @roberthermosillo.bsky.social · May 22

Some seriously impressive neuroscience by @benjaminkay.bsky.social showing how stimulant use effects the brain.

Benjamin Kay @benjaminkay.bsky.social · May 22

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

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Robert Hermosillo @roberthermosillo.bsky.social · Mar 8

It's tragic. Also, consider the tremendous loss of work hours that went into writing, reviewing, preliminary data collection, and grant support staffing hours that went into every one of these grants.

Robert Hermosillo @roberthermosillo.bsky.social · Jan 29

To all the scientists out there who need to hear this right now, you are part of a legacy of scientists who changed the world. Keep going.

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Robert Hermosillo @roberthermosillo.bsky.social · Mar 26

We built a tool that allows researchers to explore and contribute to these probabilistic maps. Check out the MIDB Precision Brain Atlas to download the neural network region sets: midbatlas.io. Get individual brain maps from the #ABCDstudy here nda.nih.gov

Robert Hermosillo @roberthermosillo.bsky.social · Mar 26

We also explore an example use case for probabilistic maps, highlighting their potential for use in targeted neuromodulation such as TMS treatment for depression. (8/8)

Robert Hermosillo @roberthermosillo.bsky.social · Mar 26

Using data from the #HCPD study we find that network topography is fairly well-preserved from 8 to 21 years old. (7/8)

Robert Hermosillo @roberthermosillo.bsky.social · Mar 26

Using this technique you can identify regions where networks overlap, which we call integration zones, that are similar to hubs that others have identified. (6/8)

Robert Hermosillo @roberthermosillo.bsky.social · Mar 26

We developed a procedure called OMNI mapping that allows multiple networks to overlap. We quantified the number of overlapping networks in an individual, and for matched groups of ~3,000 subjects each to identify integration zones. (5/8)

Robert Hermosillo @roberthermosillo.bsky.social · Mar 26

We show that region sets derived from probabilistic maps not only demonstrate higher within-network connectivity compared to conventional region sets, but also demonstrate higher brain-behavior reliability than standard whole-brain parcellations (4/8).

Robert Hermosillo @roberthermosillo.bsky.social · Mar 26

Leveraging large independent groups (n=~3000 each, balanced for demographics) from the #ABCDstudy, we demonstrate that the probabilistic maps show high between-group reliability (3/8).

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Robert Hermosillo @roberthermosillo.bsky.social · Mar 26

While the general location of functional neural networks is similar across individuals, there is vast person-to-person topographic variability. Using multiple community detection, we identified reliable individualized network maps in the cortex and subcortical structures (2/8).