Lightnews — Scholar-powered news

Reposted by Ronald Beavis ❌

Reece Martin @rmtransit.bsky.social · 16h

Everyone in Toronto knows the streetcars are slow and mismanaged (I wish our politicians actually *did* something about this), and yet we spent a generation of transit investments on building what amounts to more of them (which will be poorly run) in places we should have built subways.

2 1 34

Reposted by Ronald Beavis ❌

Forbes @forbes.com · 1d

Oracle zero-day vulnerabilities are being targeted by at least one major cybercrime group and the FBI says it's looking bad.

FBI Is Warning Companies To Patch Their Oracle Databases Immediately

Oracle zero-day vulnerabilities are being targeted by at least one major cybercrime group and the FBI says it's looking bad.

www.forbes.com

25 100 210

Reposted by Ronald Beavis ❌

Alex Usher @alexusherhesa.bsky.social · 19h

1) Classic Canadian fallacy that the answer to a labour shortage is that we need more bodies, not more efficiency/better training etc

2) Everyone knows that we admit about 100,000 new people into skilled trades apprenticeships every year, right? Right?

The Globe and Mail @theglobeandmail.com · 20h

Carney’s building agenda could be hamstrung by labour shortages, Deloitte report says

Report says Canada needs around half a million more tradespeople to meet Mr. Carney’s ambitions for housing and infrastructure

www.theglobeandmail.com

2 3 11

Reposted by Ronald Beavis ❌

Denise Wheeler @denisedwheeler.bsky.social · 1d

Reuters photographer Jonathan Ernst noticed that Bondi flipped open a file during the Senate hearing and he zoomed in.

Inside were her crib notes for attacking the senators.

The GOP now practicing Cliff's Notes Fascism

In other words, under oath Bondi was purely a performance.

Bondi senate hearing had a folder full of notes for attacking the senators

780 6.7K 16K

Ronald Beavis ❌ @ronbeavis.bsky.social · 15h

Personally, I think a result isn't really worth pursuing unless the underlying protein has been observed in >1000 LC/MS/MS runs & the feature of interest has been observed a few hundred times by multiple groups. But, I am―as everyone knows―more than a bit of an odd ball.

1

Ronald Beavis ❌ @ronbeavis.bsky.social · 15h

Michael is involved in a data based effort to do a better job (APPRIS) & I found his enthusiasm for using the preponderance of information from as many sources as possible to be very encouraging.

Ronald Beavis ❌ @ronbeavis.bsky.social · 15h

For those of you who haven't noticed, I have really enjoyed the posts by @michaeltress.bsky.social in response to my earlier rant involving the use of rules to select special splice variant mRNA (#CanonFolly).

1

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

All proteins matter!
www.cell.com/iscience/ful...

Overcoming research bias: The untapped potential of biomedically important but understudied proteins

Biochemistry; Medical biochemistry; Omics; Proteomics

www.cell.com

1 1 9

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

Maybe HUPO could offer a prize for solving this particular mystery!

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

Has anyone ever figured out what is so special/important about the sequence "...SP..." that all chordates have dozens of kinases that only phosphorylate that "S"? #proteomics

1

Reposted by Ronald Beavis ❌

Luke Kawa @ljkawa.bsky.social · 1d

Bombshell report from The Information is sparking an AI selloff:

Renting out access to Nvidia chips does not appear to be a fantastic money-maker, based on internal docs from Oracle

sherwood.news/markets/orac...

Oracle tumbles after report that it’s lost nearly $100 million from renting out access to Nvidia’s Blackwell chips

Early returns from the AI boom look tiny for Oracle, per The Information....

sherwood.news

4 10 28

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

This particular issue was pointed out last year, but it still makes the same misinterpretation to this day (I just tried it myself).
defector.com/whatever-ai-...

Whatever AI Looks Like, It's Not | Defector

There is a very funny viral tweet going around that features a screenshot of a Google search result for “austria-hungary in space.” You can try the search yourself. This is what Google returns: In 188...

defector.com

1

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

If any hypothesis you are making requires "all other factors being equal", the sad truth is that they never work out to be that way.

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

TSHZ2:p (teashirt zinc finger homeobox 2), apart from a dumb name, is an example of the use of multiple zinc-finger domains on proteins with a single cward homeodomain. In this type of pattern, most of the sequence is structureless, with pS/T acceptors flanking selected zinc fingers. #proteomics

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

"... everything is increasingly computerised and automated but nothing works ..."
gfsc.community/our-plan-to-...

Building bottom-up resistance to billionaire technology

We shouldn't need platforms owned by the biggest losers on the planet to live happy, healthy, connected lives. Our fledgling network of technologists and organisers aims to make tech billionaires obso...

gfsc.community

Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

It could be argued that "Quisling" would be a better parallel, but it is probably a potayto-potahto type situation.

3

Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

It is one of those cases where trying to apply rules to select a single translation simply doesn't work in practice.

1

Reposted by Ronald Beavis ❌

Le Monde @lemonde.fr · 2d

OpenAI passe une commande géante de puces électroniques à AMD, dont il va devenir actionnaire

Avec ce partenariat, OpenAI montre son intention de diversifier ses sources d’approvisionnement en semi-conducteurs, pour ne pas dépendre que du numéro un du secteur, l’américain Nvidia, avec qui il a passé un accord en septembre.

www.lemonde.fr

1 3 8

Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

I don't know if there is anything you can do at the primary reporting level: whoever uses your data can convert any well-thought out annotation scheme to simple binary. And I would argue that the current literature precedents would strongly encourage that type of transformation.

1 1

Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

Both of these DNA interaction domains act by locating themselves into a major groove in chromosomal DNA. The length of the IDR between them determines how far apart the appropriate grooves can be (in this case adjacent).

Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

HNF1B:p (hepatocyte nuclear factor 1 homeobox B) has an nward λ repressor-like DNA-binding domain and a nearby cward homeodomain. The human protein only has S/T+phosphoryl acceptors on the N-flank of the 1ˢᵗ domain, but mouse sees fit to add some to the C-flank of the 2ⁿᵈ. #proteomics

1

Ronald Beavis ❌ @ronbeavis.bsky.social · 3d

I am always more than a little skeptical when someone characterizes phosphorylation acceptor either observed or not (0/1). Pretty much the definition of a base rate fallacy. #proteomics

1 1 2

Ronald Beavis ❌ @ronbeavis.bsky.social · 3d

HMBOX1:p (homeobox containing 1) has a cward homeodomain & a central λ repressor-like, DNA-binding domain. Both act together to provide the protein's specific DNA binding, but unlike HOX proteins the occupied S+phosphoryl acceptors sit on the N-flank of the λ repressor-like domain. #proteomics

Reposted by Ronald Beavis ❌

Extreme Temperatures Around the World @extremetemps.bsky.social · 5d

3 OCTOBER 2025
Save this map for the books because this is HISTORIC

From 36C in SPAIN to snow in the Balkans

Unbelievable maximum temps <5C at low elevations;
One for all:Kraljevo,SERBIA 215m asl Min 0.4 Max 4.2
with few hours of snow.
Not even Centenarians had ever lived this

2 65 130

Reposted by Ronald Beavis ❌

Alex Speed @awhspeed.bsky.social · 5d

Is it correct to say an imine is "enolizable" if it has alpha protons? I guess an aza-enolate is a thing, so it seems fine to me to say that.

5 3 13