Ronald Beavis ❌
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ronbeavis.bsky.social
Ronald Beavis ❌
@ronbeavis.bsky.social
Doing science for money since 1981.
Putting it online since 1995.
Does not engage in cancer research.
QA >> QC
I enjoy doing things I am not very good at doing.
I tend to be overly mechanistic when thinking about things, but to my (oddball) mind, unless it is being secreted by a prokaryote resident in the stomach, it does have to start out as part of a translated sequence from somewhere in the oral, esophageal or gastric mucosal epithelium.
December 3, 2025 at 4:28 PM
Looking through the literature, even though it is clearly identified as a human gastric juice component, there doesn't seem to be any gene listed as the source of this little guy.
December 3, 2025 at 2:15 PM
Reposted by Ronald Beavis ❌
My favourite example of this is Apple autocorrect: a software demonstrably getting worse every single passing day.

The product has obviously degraded. I expect more typos more often. I expect correctly spelled words to be changed automatically to other words. Sometimes it just randomly adds a word.
December 1, 2025 at 12:48 PM
Thanks to everyone who contributed. The answer is largely "no", although there have been some efforts on the TF side. There is also a concern about the QA/QC involved in creating TF & E3 specificity lists, although that sort of concern is pretty common (& justifiable) in any high-throughput effort.
December 1, 2025 at 5:21 PM
The latter.
December 1, 2025 at 4:14 PM
Much in the spirit of Smith's "i, Robot".
November 30, 2025 at 8:42 PM
METAPs may require a name change, given the experimental observation of its willingness to remove a leucine when it happens to be at the start of translation. #proteomics
November 30, 2025 at 6:12 PM
Reposted by Ronald Beavis ❌
I do not accept the delineation of “predatory” journals when these for profits are not considered predatory simply because of prestige. And yeah, system has been broke for quite a while and now is just accelerating. One day scientists will realize what “publishing” means and doesn’t mean. I hope.
November 30, 2025 at 2:14 PM
Reposted by Ronald Beavis ❌
Particularly when the 'most prestigious' journals have their share of problematic publications & retractions but try to hide or delay a call on those in every manner imaginable.
Then again, the publishing system is also reflecting how broken our university & funding systems are.
November 30, 2025 at 3:25 PM
Reposted by Ronald Beavis ❌
The guy mentioned had 45 retraction, all on the same journal (Science of the Total Environment) before someone said, "Well, there is something wrong here." Academy and founding agencies reward this hyperprolific behavior. Mass spec field is not an exception.
November 30, 2025 at 2:25 PM
Goes without saying, but when are we expecting to see routine proteoform annotation included with this type of information?
November 30, 2025 at 4:01 PM
What I don't know is how noisy this sort of information is in practice. In many areas (e.g., PPI information) the push tends to be for larger & larger lists, which ironically means that they become less useful for any sort of predictive application. Are TF-target lists immune to this pressure?
November 30, 2025 at 2:39 PM
The entire scientific publishing world has made nothing but wrong turns since the old regime of printing magazines & mailing them out on a regular basis became obsolete.
November 30, 2025 at 1:38 PM