Rosalie Heilig
@rosalieheilig.bsky.social
Innate immunity, cell death, inflammation, mitochondria and viruses. CRUK Scotland Institute, Glasgow
Reposted by Rosalie Heilig
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 21, 2025 at 12:59 PM
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Reposted by Rosalie Heilig
Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.
November 20, 2025 at 3:29 PM
Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.
Reposted by Rosalie Heilig
Jo in our team - we are looking for a PhD student, postdoc or lab manager!
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
Postdoc or PhD student position in molecular dissection of cellular crosstalk in the intestinal mucosa
lnkd.in
November 11, 2025 at 6:20 AM
Jo in our team - we are looking for a PhD student, postdoc or lab manager!
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
Reposted by Rosalie Heilig
Correct link: www.findaphd.com/phds/?Keywor...
dave boucher PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 10, 2025 at 7:47 PM
Correct link: www.findaphd.com/phds/?Keywor...
Reposted by Rosalie Heilig
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 3, 2025 at 11:15 AM
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Reposted by Rosalie Heilig
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
September 8, 2025 at 8:15 AM
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Reposted by Rosalie Heilig
Great to see this out. A story that spanned continents, cities and budget codes…
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213 - Nature Communications
RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation mechanism induced by immune ...
www.nature.com
May 13, 2025 at 9:51 AM
Great to see this out. A story that spanned continents, cities and budget codes…
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
Reposted by Rosalie Heilig
Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...
Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection
Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8
and GSDMD activation in murine macrophages; however, how macrophages defend against
Yersinia when caspase-8 or YopJ ...
www.cell.com
January 16, 2025 at 11:09 PM
Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...