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Reposted by Santiago Rodríguez Seguí

Ehsan Hamzehpoor @hamzehsan.bsky.social · Aug 19

“You are here to learn to ride a bicycle, not to invent a bicycle.” 🚲🧪
Read my story in Science Magazine on how I dealt with my "Mid-PhD Crisis".
www.science.org/content/arti...

@science.org
@sciencecareers.bsky.social
#ScienceWorkingLife
#AcademicChatter
#AcademicTwitter
#ScienceTwitter

Science Magazine @science.org · Aug 18

"For half an hour, I vented everything I had been holding in for months … my supervisor … then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." https://scim.ag/4lt1Ru0

An illustration of a man riding a bike surrounded by wheels and other bike parts, with text: How a Ph.D. is like riding a bike

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Aug 13

Neurons and β-cells share many similarities, including the expression of very specific transcription factors. This prompted a long-standing search for connections between diabetes and mental disorders. This amazing discovery finally reveals a mechanistic link!
www.nature.com/articles/s41...

A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors - Nature Neuroscience

The mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian factors drive behavioral fluctuati...

www.nature.com

Reposted by Santiago Rodríguez Seguí

Charlotte Harrison @charlotteh560.bsky.social · Aug 6

Can amylin-based drugs upstage GLP-1 agonists? They could avoid muscle loss and gastrointestinal side effects of current obesity therapies. My latest for @natbiotech.nature.com rdcu.be/ezwbM

Can amylin-based drugs upstage GLP-1 agonists?

Nature Biotechnology - Analogs of the pancreatic peptide hormone amylin are making strides in obesity as developers zoom in on oral drugs that can emulate or even improve on injectable GLP-1...

rdcu.be

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Aug 2

Hoy sábado a medianoche sale nuestra entrevista en el programa "Desde el Conocimiento" por #C5N ¡Gracias a la producción del canal por la invitación para difundir nuestro trabajo en el #IFIBYNE! Transmisión online: www.c5n.com/vivo

Reposted by Santiago Rodríguez Seguí

Daniel Drucker @danieljdrucker.bsky.social · Jul 21

Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @natcomms.nature.com www.nature.com/articles/s41...

A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics - Nature Communications

Here the authors show that human pancreatic islets adapt during pregnancy with increased α-cell area and GLP-1 abundance, while key differences from islet adaptations in mouse pregnancy include unchan...

www.nature.com

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Reposted by Santiago Rodríguez Seguí

John De Vos @jdevos.bsky.social · Jul 10

💥 A single infusion into the portal vein of embryonic stem cell-derived pancreatic islet result in 12/12 patients free of severe hypoglycemic and 83% with insulin independence at one year.
However, one death due to the immunosuppressive treatment.

buff.ly/ZI14m2i

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 24

¡Gracias a la Agencia de Difusión de la Universidad Nacional de San Martin por ayudarnos con la difusión de nuestro trabajo en el #IFIBYNE, y de la difícil situación por la que está atravesando el sistema científico-tecnológico de Argentina!

www.agenciatss.com.ar/una-hormona-...

Una hormona del estrés contra la diabetes – Agencia TSS Noticias de ciencia y tecnología

www.agenciatss.com.ar

Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 23

Missed our @eisg2025.bsky.social post? If you study beta cell function using rat islets or INS-1 cells, check out Ri-lnc1! Strongly linked to mature beta cells but missing from current rat genome annotations. Overlooked? Happy to collaborate—just contact us!

Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 12

Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇

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Reposted by Santiago Rodríguez Seguí

Francis Lynn 🇨🇦 @nictitate.bsky.social · Jun 20

Stem cell islets for those living with T1D! www.nejm.org/doi/full/10....

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

www.nejm.org

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 13

Already on my way back to Argentina! Every trip must come to an end, but this one has truly been an amazing experience that will leave a lasting mark. Looking forward to consolidating the exciting new collaborations that will drive future work!

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 13

Amazing talks by @diegobalboa.bsky.social, @labspagnoli.bsky.social, Simona Chera and many other colleagues yesterday at @eisg2025.bsky.social ! I'm also really glad for the opportunity to share our recently published work. Looking forward to more exciting talks today!

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 12

www.frontiersin.org/journals/end...

Frontiers | Transcriptional signature of islet neogenesis-associated protein peptide-treated rat pancreatic islets reveals induction of novel long non-coding RNAs

Background: Diabetes mellitus is characterized by chronic hyperglycemia with loss of β-cell function and mass. An attractive therapeutic approach to treat pa...

www.frontiersin.org

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 12

Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 11

Did you know that the glucocorticoid receptor fine-tunes physiological pancreas development from the earliest progenitor stages? Below, an image worth a thousand words. Want to know more? Visit us at Poster #135 @eisg2025.bsky.social today, Wednesday, at 16:55!

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Reposted by Santiago Rodríguez Seguí

Helena Klara Jambor @helenajambor.bsky.social · Jun 11

#TCTeAC brought more stickers for day2, find the girl with the lipstick 💄 to get yours! 😉

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 10

Thank you, Philip Allan Seymour, for the great meeting today in Copenhagen and for contributing key experiments to our follow-up work on the role of glucocorticoids in pancreas development. Looking forward to getting this continuation story out soon!

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 9

Finally! All the pieces are in place for the last stage of an amazing trip. Excited to share our results @eisg2025.bsky.social, showing that endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in pancreatic progenitors of mice and humans!

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Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 7

It was an honor to present our most recent results on the characterization of Procr-like cells in #pancreas #development at the Shanghai Institute of Biochemistry and Cell Biology. Thank you, Dr. Yi Zeng and team, for the warm reception and the engaging perspectives!

Santiago Rodríguez Seguí @rseguilab.bsky.social · Jun 3

Everything is ready for the second stage of my trip. Shanghai awaits—looking forward to interesting discussions on the characterization and role of Procr-like cells in #pancreas #development! @ifibyne @ubaglobal #DiabetesResearch

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Santiago Rodríguez Seguí @rseguilab.bsky.social · May 30

It was a pleasure discussing our latest results with Prof. Cheng-Ran Xu today at Peking University and learning more about his breakthrough advances in endocrine cell specification in mice and humans. Looking forward to a productive follow-up! #StemCells #DiabetesResearch

Santiago Rodríguez Seguí @rseguilab.bsky.social · May 30

You can say it louder, but not clearer.
"Scienticide" = the systematic eradication of any possible trace of scientific work in Argentina.

www.nature.com/articles/d41...

‘Scienticide’ in Argentina sparks huge protest by researchers

Hundreds of activists wearing gas masks took to the streets to call out their government for slashing science funding.

www.nature.com

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Santiago Rodríguez Seguí @rseguilab.bsky.social · May 27

¡Gracias @CONICETDialoga y Bruno Geller por esta excelente nota difundiendo los principales resultados de nuestro trabajo
@ifibyne publicado recientemente en Development!

www.conicet.gov.ar/diabetes-tip...

--
Thank you @CONICETDialoga for this excellent note!

INICIO

Organismo dedicado a la promoción de la ciencia y la tecnología en la Argentina.

conicet.gov.ar

Santiago Rodríguez Seguí @rseguilab.bsky.social · May 27

Thank you, Jorge! Your support, along with Miguel Angel's expertise with the immunos, was instrumental during the initial steps of this project. Looking forward to exploring potential follow-ups together!

Jorge Ferrer @jorge-ferrer.bsky.social · May 26

Congratulations for this study in @Dev_journal, no small feat in Argentina's anti-Science climate

Santiago Rodríguez Seguí @rseguilab.bsky.social · May 15

Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal!
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....

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Santiago Rodríguez Seguí @rseguilab.bsky.social · May 26

It was great to present the work of our lab at #IFIBYNE, for the Endocrinology Department at #PekingUniversity . Thank you, Wei Rui and team, for the warm welcome and very interesting feedback! Thank you #UBAInternacional for supporting this #InternationalResearch between #Argentina & #China.

Santiago Rodríguez Seguí @rseguilab.bsky.social · May 26

bsky.app/profile/rseg...

Santiago Rodríguez Seguí @rseguilab.bsky.social · May 15

Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal!
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....

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