Rockefeller University Press
@rupress.org
We publish the scientific journals @jcb.org, @jem.org, @jgp.org, @jhumimmunity.org, and co-publish @lsajournal.org. Visit our journals at https://rupress.org
New @jhumimmunity.org from Tusseau, Desvignes, Belot et al. @ciri-lyon.bsky.social: Novel TLR7 GOF variant (P435S) causing early onset #lupus with #neuroinflammation. Functional validation & review of all known #TLR7 GOF cases. A new dive into TLR7 mediated #autoimmunity. rupress.org/jhi/article/...
January 12, 2026 at 7:15 PM
New @jhumimmunity.org from Tusseau, Desvignes, Belot et al. @ciri-lyon.bsky.social: Novel TLR7 GOF variant (P435S) causing early onset #lupus with #neuroinflammation. Functional validation & review of all known #TLR7 GOF cases. A new dive into TLR7 mediated #autoimmunity. rupress.org/jhi/article/...
@jcb.org: Chatterjee et al reveal that structural snapshots of different conformations of α-hemolysin #toxin from #Staphylococcus aureus, identified from the prehemolytic & posthemolytic stages, offer step-by-step oligomerization of α-HL during erythrocyte #membrane lysis rupress.org/jcb/article/...
January 12, 2026 at 6:30 PM
@jcb.org: Chatterjee et al reveal that structural snapshots of different conformations of α-hemolysin #toxin from #Staphylococcus aureus, identified from the prehemolytic & posthemolytic stages, offer step-by-step oligomerization of α-HL during erythrocyte #membrane lysis rupress.org/jcb/article/...
In @jhumimmunity.org: Groen, @benhale.bsky.social et al. identify interferon-λ #autoantibodies in 11.8% of those with #CysticFibrosis, a prevalence >10-fold higher than expected. In vitro & clinical analyses suggest the antibodies may impact mucosal pathology. rupress.org/jhi/article/...
January 12, 2026 at 5:45 PM
In @jhumimmunity.org: Groen, @benhale.bsky.social et al. identify interferon-λ #autoantibodies in 11.8% of those with #CysticFibrosis, a prevalence >10-fold higher than expected. In vitro & clinical analyses suggest the antibodies may impact mucosal pathology. rupress.org/jhi/article/...
In @jcb.org: Using #Drosophila neurons, Nitish Kumar, Melissa Rolls et al. identify a pathway that communicates changes in #microtubule dynamics to the #nucleus. This pathway in turn modulates the expression of γTubulin, the central microtubule nucleator. rupress.org/jcb/article/...
#Neuroscience
#Neuroscience
January 12, 2026 at 5:00 PM
In @jcb.org: Using #Drosophila neurons, Nitish Kumar, Melissa Rolls et al. identify a pathway that communicates changes in #microtubule dynamics to the #nucleus. This pathway in turn modulates the expression of γTubulin, the central microtubule nucleator. rupress.org/jcb/article/...
#Neuroscience
#Neuroscience
In @jcb.org, Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Chromatin
#CellCycle #Chromatin
January 9, 2026 at 6:31 PM
In @jcb.org, Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Chromatin
#CellCycle #Chromatin
In @jcb.org, Chou, McCartney et al. @cmu.edu demonstrate coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
January 9, 2026 at 5:45 PM
In @jcb.org, Chou, McCartney et al. @cmu.edu demonstrate coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
At long last, a plausible explanation for the tight association between #keratin 15 and the epithelial progenitor epithelial cell state in skin is provided in a new study by Redmond, Coulombe et al. @umich.edu in @jcb.org: rupress.org/jcb/article/...
#Cytoskeleton #StemCells
#Cytoskeleton #StemCells
January 9, 2026 at 5:00 PM
At long last, a plausible explanation for the tight association between #keratin 15 and the epithelial progenitor epithelial cell state in skin is provided in a new study by Redmond, Coulombe et al. @umich.edu in @jcb.org: rupress.org/jcb/article/...
#Cytoskeleton #StemCells
#Cytoskeleton #StemCells
In @jhumimmunity.org: Khoryati et al. identify a T cell receptor Vβ21.3 signature in #SARSCoV2–related multisystem inflammatory syndrome in adults (MIS-A) similar to that previously reported in children (MIS-C), suggesting a shared immune-related mechanism between the two rupress.org/jhi/article/...
January 8, 2026 at 6:00 PM
In @jhumimmunity.org: Khoryati et al. identify a T cell receptor Vβ21.3 signature in #SARSCoV2–related multisystem inflammatory syndrome in adults (MIS-A) similar to that previously reported in children (MIS-C), suggesting a shared immune-related mechanism between the two rupress.org/jhi/article/...
In @jcb.org, Yan, @nieminm.bsky.social et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. rupress.org/jcb/article/...
January 8, 2026 at 5:00 PM
In @jcb.org, Yan, @nieminm.bsky.social et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. rupress.org/jcb/article/...
📣 The @jcb.org Cover of the Year 2025 goes to this beautiful confocal microscopy image of an adult #Drosophila eye from this May 2025 study (rupress.org/jcb/article/...). Congrats to Vaisaly R. Nath, Padinjat Raghu (@rpadinjat.bsky.social) and colleagues, and thank you to everyone who voted!
January 8, 2026 at 4:18 PM
📣 The @jcb.org Cover of the Year 2025 goes to this beautiful confocal microscopy image of an adult #Drosophila eye from this May 2025 study (rupress.org/jcb/article/...). Congrats to Vaisaly R. Nath, Padinjat Raghu (@rpadinjat.bsky.social) and colleagues, and thank you to everyone who voted!
In @jcb.org, Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
January 7, 2026 at 7:30 PM
In @jcb.org, Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
In @jcb.org, Byrd, Marmorale, Buchan et al. conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
January 7, 2026 at 7:00 PM
In @jcb.org, Byrd, Marmorale, Buchan et al. conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
New research @jcb.org from Lee, Higgs et al. shows how #INF2, a key #actin regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. rupress.org/jcb/article/...
#CellBiology
#CellBiology
January 7, 2026 at 6:30 PM
New research @jcb.org from Lee, Higgs et al. shows how #INF2, a key #actin regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. rupress.org/jcb/article/...
#CellBiology
#CellBiology
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. In @jcb.org, van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
January 7, 2026 at 5:45 PM
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. In @jcb.org, van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
#Collagen IV intercellular concentrations mediate cell–cell #adhesion in the #Drosophila #adipose tissue. New @jcb.org study from Almasoud, Franz et al. @ucl-cdb.bsky.social finds that the adipose tissue has apical-basal cell #polarity, which regulates this adhesion. rupress.org/jcb/article/...
January 7, 2026 at 5:31 PM
#Collagen IV intercellular concentrations mediate cell–cell #adhesion in the #Drosophila #adipose tissue. New @jcb.org study from Almasoud, Franz et al. @ucl-cdb.bsky.social finds that the adipose tissue has apical-basal cell #polarity, which regulates this adhesion. rupress.org/jcb/article/...
In @jcb.org, Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...
January 7, 2026 at 4:15 PM
In @jcb.org, Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...
In @jhumimmunity.org, Parvaneh, Ziaee et al. present a patient harboring the TLR7 F507S mutation who initially presented with refractory #thrombocytopenia that evolved into #SLE with subtle neurologic features, accompanied by #hypertriglyceridemia. rupress.org/jhi/article/...
#Autoimmunity
#Autoimmunity
January 7, 2026 at 3:45 PM
In @jhumimmunity.org, Parvaneh, Ziaee et al. present a patient harboring the TLR7 F507S mutation who initially presented with refractory #thrombocytopenia that evolved into #SLE with subtle neurologic features, accompanied by #hypertriglyceridemia. rupress.org/jhi/article/...
#Autoimmunity
#Autoimmunity
In @jgp.org, Jinglang Sun, Amy Lee et al. @utaustin.bsky.social show that the commonly used Caᵥ3 T-type channel-selective antagonists, ML218 & Z944, modulate the activity of Caᵥ1.4 L-type channels through a mechanism involving the dihydropyridine-binding site. rupress.org/jgp/article/...
January 7, 2026 at 3:45 PM
In @jgp.org, Jinglang Sun, Amy Lee et al. @utaustin.bsky.social show that the commonly used Caᵥ3 T-type channel-selective antagonists, ML218 & Z944, modulate the activity of Caᵥ1.4 L-type channels through a mechanism involving the dihydropyridine-binding site. rupress.org/jgp/article/...
In @jcb.org, Lund et al. reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
January 7, 2026 at 3:30 PM
In @jcb.org, Lund et al. reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
In a new @jem.org study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...
January 7, 2026 at 3:15 PM
In a new @jem.org study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...
In @jcb.org, Yaqi Li et al. report a novel Cas9-based spatiotemporal gene-editing approach in #zebrafish. Given the limited germline transmission efficiency of knock-in alleles in zebrafish, this system enables rapid and high-throughput genetic screening in vivo. rupress.org/jcb/article/...
#CRISPR
#CRISPR
January 7, 2026 at 2:45 PM
In @jcb.org, Yaqi Li et al. report a novel Cas9-based spatiotemporal gene-editing approach in #zebrafish. Given the limited germline transmission efficiency of knock-in alleles in zebrafish, this system enables rapid and high-throughput genetic screening in vivo. rupress.org/jcb/article/...
#CRISPR
#CRISPR
Spotlight @jcb.org: Eunjoon Kim discusses work by Yamasaki et al. (rupress.org/jcb/article/...) on how GARLH4 regulates neuroligin sorting, demonstrating that #synapse identity is a tunable outcome of protein competition. rupress.org/jcb/article/...
#Neuroscience
#Neuroscience
January 7, 2026 at 2:15 PM
Spotlight @jcb.org: Eunjoon Kim discusses work by Yamasaki et al. (rupress.org/jcb/article/...) on how GARLH4 regulates neuroligin sorting, demonstrating that #synapse identity is a tunable outcome of protein competition. rupress.org/jcb/article/...
#Neuroscience
#Neuroscience
In @jem.org, Březina, Filipp et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/...
January 6, 2026 at 9:15 PM
In @jem.org, Březina, Filipp et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/...
Review in @jcb.org: Siqi Deng, Zhiqiang Yan et al. summarize the physiological functions and structural basis of OSCA/TMEM63 proteins, positioning them within a mechanosensitive ion channel superfamily. rupress.org/jcb/article/...
#Physiology #Neuroscience #Mechanobiology #IonChannels
#Physiology #Neuroscience #Mechanobiology #IonChannels
January 6, 2026 at 9:00 PM
Review in @jcb.org: Siqi Deng, Zhiqiang Yan et al. summarize the physiological functions and structural basis of OSCA/TMEM63 proteins, positioning them within a mechanosensitive ion channel superfamily. rupress.org/jcb/article/...
#Physiology #Neuroscience #Mechanobiology #IonChannels
#Physiology #Neuroscience #Mechanobiology #IonChannels
Review in @jcb.org: Michael Worcester, @gerryhammond.bsky.social et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study #lipids. rupress.org/jcb/article/...
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
January 6, 2026 at 8:45 PM
Review in @jcb.org: Michael Worcester, @gerryhammond.bsky.social et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study #lipids. rupress.org/jcb/article/...
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer