Sarah Gawlak
@scgawlak.bsky.social
PhD student in Cancer Sciences at Roswell Park Comprehensive Cancer Center 🧬🧪
Reposted by Sarah Gawlak
As the AACR Special Conference on Fusion-Positive Cancer comes to an end, we thank #AACRfusion26 cochairs Natasha J. Caplen, Mark E. Hatley, Ross A. Okimoto, and Kimberly Stegmaier for developing an outstanding program.
January 15, 2026 at 5:45 PM
As the AACR Special Conference on Fusion-Positive Cancer comes to an end, we thank #AACRfusion26 cochairs Natasha J. Caplen, Mark E. Hatley, Ross A. Okimoto, and Kimberly Stegmaier for developing an outstanding program.
Reposted by Sarah Gawlak
Poster presenters shared their work with attendees Tuesday evening during the AACR Special Conference on Fusion-Positive Cancer. #AACRfusion26
January 14, 2026 at 1:45 AM
Poster presenters shared their work with attendees Tuesday evening during the AACR Special Conference on Fusion-Positive Cancer. #AACRfusion26
Reposted by Sarah Gawlak
Biomolecular Condensates Dictate the Folding Landscape of Proteins https://www.biorxiv.org/content/10.64898/2026.01.12.699095v1
January 14, 2026 at 4:49 AM
Biomolecular Condensates Dictate the Folding Landscape of Proteins https://www.biorxiv.org/content/10.64898/2026.01.12.699095v1
Reposted by Sarah Gawlak
Modelling EWS::FLI1 protein fluctuations reveal determinants of tumor plasticity in Ewing sarcoma
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Modelling EWS::FLI1 protein fluctuations reveal determinants of tumor plasticity in Ewing sarcoma - EMBO Molecular Medicine
Tumor cell plasticity drives metastasis and therapy resistance, yet its regulation by oncoprotein dosage dynamics remains poorly understood. In Ewing sarcoma (EwS), variations in EWS::FLI1 (EF) fusion...
link.springer.com
January 4, 2026 at 8:00 PM
Modelling EWS::FLI1 protein fluctuations reveal determinants of tumor plasticity in Ewing sarcoma
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Sarah Gawlak
This review examines how #circularRNAs regulate #cancer therapy–induced toxicity by modulating #apoptosis, oxidative stress, and #DNAdamage and discusses circRNAs as #biomarkers and therapeutic targets to improve outcomes. @utoronto.ca
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 21, 2025 at 12:47 AM
This review examines how #circularRNAs regulate #cancer therapy–induced toxicity by modulating #apoptosis, oxidative stress, and #DNAdamage and discusses circRNAs as #biomarkers and therapeutic targets to improve outcomes. @utoronto.ca
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reposted by Sarah Gawlak
This review describes various animal models currently used in #Osteosarcoma (OS) research, their characteristics, and advantages & disadvantages, which may help elucidate the mechanisms underlying OS progression.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 19, 2025 at 5:25 PM
This review describes various animal models currently used in #Osteosarcoma (OS) research, their characteristics, and advantages & disadvantages, which may help elucidate the mechanisms underlying OS progression.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reposted by Sarah Gawlak
Role of Myc family proteins in transcriptional regulation of growth and oncogenic transformation in fusion-positive rhabdomyosarcoma https://www.biorxiv.org/content/10.64898/2025.12.01.690506v1
December 2, 2025 at 11:47 PM
Role of Myc family proteins in transcriptional regulation of growth and oncogenic transformation in fusion-positive rhabdomyosarcoma https://www.biorxiv.org/content/10.64898/2025.12.01.690506v1
Reposted by Sarah Gawlak
Reposted by Sarah Gawlak
This review presents a comprehensive analysis of #FusionGenes in #TumorBiology, outlining their role in development and treatment, providing guidance for future research and #Clinical practice. #medsky #CancerResearch
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
November 17, 2025 at 5:57 AM
This review presents a comprehensive analysis of #FusionGenes in #TumorBiology, outlining their role in development and treatment, providing guidance for future research and #Clinical practice. #medsky #CancerResearch
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
Reposted by Sarah Gawlak
This study highlights NKD2 as a key regulator of #BoneMetabolism via #Wnt/#β-catenin and mTORC1 signaling to enhance #Osteogenesis and reduce #Postmenopausal #BoneLoss. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
November 6, 2025 at 3:53 PM
This study highlights NKD2 as a key regulator of #BoneMetabolism via #Wnt/#β-catenin and mTORC1 signaling to enhance #Osteogenesis and reduce #Postmenopausal #BoneLoss. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
Reposted by Sarah Gawlak
TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma https://www.biorxiv.org/content/10.1101/2025.11.03.686399v1
November 5, 2025 at 4:49 PM
TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma https://www.biorxiv.org/content/10.1101/2025.11.03.686399v1
Reposted by Sarah Gawlak
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
go.nature.com
October 28, 2025 at 6:50 PM
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Reposted by Sarah Gawlak
New research reveals VER inhibits #Osteosarcoma growth by blocking the #PI3K/#AKT pathway both in vitro and in vivo, positioning it as a promising #therapeutic candidate for OS treatment. #DrugDiscovery #CancerTherapeutics #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
October 30, 2025 at 12:51 AM
New research reveals VER inhibits #Osteosarcoma growth by blocking the #PI3K/#AKT pathway both in vitro and in vivo, positioning it as a promising #therapeutic candidate for OS treatment. #DrugDiscovery #CancerTherapeutics #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
Reposted by Sarah Gawlak
STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma https://www.biorxiv.org/content/10.1101/2025.10.24.684275v1
October 25, 2025 at 7:48 PM
STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma https://www.biorxiv.org/content/10.1101/2025.10.24.684275v1
Reposted by Sarah Gawlak
(Re)defining the human chromatome: an integrated meta-analysis of localization, function, abundance, physical properties and domain composition of chromatin proteins https://www.biorxiv.org/content/10.1101/2025.10.10.680841v1
October 12, 2025 at 5:04 PM
(Re)defining the human chromatome: an integrated meta-analysis of localization, function, abundance, physical properties and domain composition of chromatin proteins https://www.biorxiv.org/content/10.1101/2025.10.10.680841v1
Reposted by Sarah Gawlak
This latest study shows that Yanghe Decoction suppresses #Osteosarcoma (OS) cell processes by inducing #Apoptosis, #MitochondrialDysfunction & boosting #cisplatin sensitivity, promising synergistic approaches to OS treatment. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
October 12, 2025 at 2:30 PM
This latest study shows that Yanghe Decoction suppresses #Osteosarcoma (OS) cell processes by inducing #Apoptosis, #MitochondrialDysfunction & boosting #cisplatin sensitivity, promising synergistic approaches to OS treatment. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
Reposted by Sarah Gawlak
Now online in Cancer Discovery @aacrjournals.bsky.social: Epigenetic and Transcriptional Programs Define #Osteosarcoma Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, Alejandro Sweet-Cordero, and colleagues doi.org/10.1158/2159... @ucsfchildrens.bsky.social
October 3, 2025 at 4:48 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Epigenetic and Transcriptional Programs Define #Osteosarcoma Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, Alejandro Sweet-Cordero, and colleagues doi.org/10.1158/2159... @ucsfchildrens.bsky.social
Reposted by Sarah Gawlak
Acidic transcription factors position the genome at nuclear speckles through transcription dependent and independent mechanisms https://www.biorxiv.org/content/10.1101/2025.10.01.679912v1
October 3, 2025 at 1:30 PM
Acidic transcription factors position the genome at nuclear speckles through transcription dependent and independent mechanisms https://www.biorxiv.org/content/10.1101/2025.10.01.679912v1
Reposted by Sarah Gawlak
🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Structural variants in the 3D genome as drivers of disease - Nature Reviews Genetics
Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects ...
www.nature.com
July 7, 2025 at 11:12 AM
🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Reposted by Sarah Gawlak
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing #Sarcoma Proliferation and Migration
advanced.onlinelibrary.wiley.com/doi/full/10....
advanced.onlinelibrary.wiley.com/doi/full/10....
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularizatio...
advanced.onlinelibrary.wiley.com
September 28, 2025 at 1:24 PM
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing #Sarcoma Proliferation and Migration
advanced.onlinelibrary.wiley.com/doi/full/10....
advanced.onlinelibrary.wiley.com/doi/full/10....
Reposted by Sarah Gawlak
CK2 inhibitor CX-4945 targets EWS-FLI1 protein abundance and shows anti-tumor activity in metastatic mouse models of Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.09.24.677357v1
September 26, 2025 at 11:48 PM
CK2 inhibitor CX-4945 targets EWS-FLI1 protein abundance and shows anti-tumor activity in metastatic mouse models of Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.09.24.677357v1
Reposted by Sarah Gawlak
Automated FRET Analysis for Enhanced Characterization of Protein-Protein Interactions https://www.biorxiv.org/content/10.1101/2025.09.20.674865v1
September 21, 2025 at 10:47 PM
Automated FRET Analysis for Enhanced Characterization of Protein-Protein Interactions https://www.biorxiv.org/content/10.1101/2025.09.20.674865v1
Reposted by Sarah Gawlak
Transcriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase https://www.biorxiv.org/content/10.1101/2025.09.02.673849v1
September 6, 2025 at 3:49 PM
Transcriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase https://www.biorxiv.org/content/10.1101/2025.09.02.673849v1
Reposted by Sarah Gawlak
Review: Transcriptomics in the era of long-read sequencing www.nature.com/articles/s41... (read free: rdcu.be/efBjP) 🧬🖥️🧪
March 29, 2025 at 8:57 AM
Review: Transcriptomics in the era of long-read sequencing www.nature.com/articles/s41... (read free: rdcu.be/efBjP) 🧬🖥️🧪