Schmitt-Lab@HHU
@schmitt-lab.bsky.social
Professor of Biochemistry
Research interest: membrane biochemistry with focus on ABC transporters, drug efflux systems, bacterial secretion system, lantibiotics, and deubiquitinases
https://www.biochemistry1.hhu.de
Research interest: membrane biochemistry with focus on ABC transporters, drug efflux systems, bacterial secretion system, lantibiotics, and deubiquitinases
https://www.biochemistry1.hhu.de
Reposted by Schmitt-Lab@HHU
🌟 New Tool Alert!
We present MemPrO – a toolkit for orienting and building membrane protein systems:
✅ Membrane protein orientation ✅ Mixed membrane building ✅ Double membranes & curvature ✅ Peptidoglycan cell wall support
🔗 github.com/pstansfeld/mempro 📖 pubs.acs.org/doi/10.1021/...
We present MemPrO – a toolkit for orienting and building membrane protein systems:
✅ Membrane protein orientation ✅ Mixed membrane building ✅ Double membranes & curvature ✅ Peptidoglycan cell wall support
🔗 github.com/pstansfeld/mempro 📖 pubs.acs.org/doi/10.1021/...
MemPrO: A Predictive Tool for Membrane Protein Orientation
Membrane proteins play a vital role in numerous cellular processes, including ion transport, intercellular communication, and antibiotic resistance. Ensuring their accurate orientation within lipid bi...
pubs.acs.org
December 25, 2025 at 10:03 PM
🌟 New Tool Alert!
We present MemPrO – a toolkit for orienting and building membrane protein systems:
✅ Membrane protein orientation ✅ Mixed membrane building ✅ Double membranes & curvature ✅ Peptidoglycan cell wall support
🔗 github.com/pstansfeld/mempro 📖 pubs.acs.org/doi/10.1021/...
We present MemPrO – a toolkit for orienting and building membrane protein systems:
✅ Membrane protein orientation ✅ Mixed membrane building ✅ Double membranes & curvature ✅ Peptidoglycan cell wall support
🔗 github.com/pstansfeld/mempro 📖 pubs.acs.org/doi/10.1021/...
Reposted by Schmitt-Lab@HHU
Atomic resolution structure of spinach rubisco reveals protons and dynamics www.biorxiv.org/content/10.64898/2025.12.22.696010v1 #cryoem
December 24, 2025 at 9:42 AM
Atomic resolution structure of spinach rubisco reveals protons and dynamics www.biorxiv.org/content/10.64898/2025.12.22.696010v1 #cryoem
Reposted by Schmitt-Lab@HHU
We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users.
www.fz-juelich.de/de/karriere/...
www.fz-juelich.de/de/karriere/...
Team Leader – Life Science Cryo-Electron Microscopy (Cryo-EM) Facility
Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C) at Forschungszentrum Jülich houses some of the world`s most advanced electron microscopes and tools for nanocharacterisation. U...
www.fz-juelich.de
December 23, 2025 at 9:42 AM
We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users.
www.fz-juelich.de/de/karriere/...
www.fz-juelich.de/de/karriere/...
Reposted by Schmitt-Lab@HHU
We’re hiring 2 Postdocs (f/m/d) in Drug–Microbiome–Host Interactions 🦠💊
Focus: how non-antibiotic drugs shape the gut microbiome, drug efficacy & side effects.
#PostdocJobs #Microbiome #AcademicJobs
Full job ad:
lisamaierlab.com/wp-content/u...
Focus: how non-antibiotic drugs shape the gut microbiome, drug efficacy & side effects.
#PostdocJobs #Microbiome #AcademicJobs
Full job ad:
lisamaierlab.com/wp-content/u...
lisamaierlab.com
December 22, 2025 at 2:08 PM
We’re hiring 2 Postdocs (f/m/d) in Drug–Microbiome–Host Interactions 🦠💊
Focus: how non-antibiotic drugs shape the gut microbiome, drug efficacy & side effects.
#PostdocJobs #Microbiome #AcademicJobs
Full job ad:
lisamaierlab.com/wp-content/u...
Focus: how non-antibiotic drugs shape the gut microbiome, drug efficacy & side effects.
#PostdocJobs #Microbiome #AcademicJobs
Full job ad:
lisamaierlab.com/wp-content/u...
Reposted by Schmitt-Lab@HHU
So structural biology is not dead after all 😋 Not a big surprise The title of this article is exactly in line with what I think.
Same applies to LLMs for scientific writing.
Same applies to LLMs for scientific writing.
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
www.nature.com
December 14, 2025 at 4:18 PM
So structural biology is not dead after all 😋 Not a big surprise The title of this article is exactly in line with what I think.
Same applies to LLMs for scientific writing.
Same applies to LLMs for scientific writing.
Reposted by Schmitt-Lab@HHU
Ups we did it again! Please mark your calender. EMBO Workshop “Lipid Code to Life”, taking place September 7–11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social 🥳 Retweets = lipidlove
December 15, 2025 at 2:36 PM
Ups we did it again! Please mark your calender. EMBO Workshop “Lipid Code to Life”, taking place September 7–11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social 🥳 Retweets = lipidlove
Reposted by Schmitt-Lab@HHU
Reposted by Schmitt-Lab@HHU
📣Interested in doing your PhD in Plant Sciences 🌱, Microbial Sciences 🦠 or Computational Biology 👩💻? @ceplas.bsky.social offers 10 fully funded PhD 🎓fellowships. Pls repost and forward to interested candidates holding BSc degree.
‼️Please RT: The CEPLAS Graduate School call for 2026 is now open! Detailed info on our website: bit.ly/4q19JWk
@hhu.de @unicologne.bsky.social @mpipz.bsky.social @fz-juelich.de @leibnizipk.bsky.social @plantsciencedbg.bsky.social
@hhu.de @unicologne.bsky.social @mpipz.bsky.social @fz-juelich.de @leibnizipk.bsky.social @plantsciencedbg.bsky.social
December 11, 2025 at 8:34 AM
📣Interested in doing your PhD in Plant Sciences 🌱, Microbial Sciences 🦠 or Computational Biology 👩💻? @ceplas.bsky.social offers 10 fully funded PhD 🎓fellowships. Pls repost and forward to interested candidates holding BSc degree.
Finally out – It is all about cholesterol
Thanks to all for this excellent collaboration
Thanks to all for this excellent collaboration
December 5, 2025 at 2:34 PM
Finally out – It is all about cholesterol
Thanks to all for this excellent collaboration
Thanks to all for this excellent collaboration
Reposted by Schmitt-Lab@HHU
PanBGC: A pangenome-inspired framework for comparative analysis of biosynthetic gene clusters
#ISMEComms from @nadineziemert.bsky.social
academic.oup.com/ismecommun/a...
#ISMEComms from @nadineziemert.bsky.social
academic.oup.com/ismecommun/a...
PanBGC: A pangenome-inspired framework for comparative analysis of biosynthetic gene clusters
Abstract. Bacterial secondary metabolites are a major source of therapeutics and play key roles in microbial ecology. These compounds are encoded by biosyn
academic.oup.com
November 30, 2025 at 1:24 PM
PanBGC: A pangenome-inspired framework for comparative analysis of biosynthetic gene clusters
#ISMEComms from @nadineziemert.bsky.social
academic.oup.com/ismecommun/a...
#ISMEComms from @nadineziemert.bsky.social
academic.oup.com/ismecommun/a...
Reposted by Schmitt-Lab@HHU
AI model Helixer predicts eukaryotic genes ab initio, directly from a plain text FASTA file.
No RNA-seq.
No protein homology.
No repeats, hints, or curated evidence.
Raw genome → accurate gene models.
Deep learning + HMM, published in @natmethods.nature.com
www.nature.com/articles/s41...
No RNA-seq.
No protein homology.
No repeats, hints, or curated evidence.
Raw genome → accurate gene models.
Deep learning + HMM, published in @natmethods.nature.com
www.nature.com/articles/s41...
Helixer: ab initio prediction of primary eukaryotic gene models combining deep learning and a hidden Markov model - Nature Methods
By leveraging both deep learning and hidden Markov models, Helixer achieves broad taxonomic coverage for ab initio gene annotation of eukaryotic genomes from fungi, plants, vertebrates and invertebrat...
www.nature.com
November 26, 2025 at 6:00 AM
AI model Helixer predicts eukaryotic genes ab initio, directly from a plain text FASTA file.
No RNA-seq.
No protein homology.
No repeats, hints, or curated evidence.
Raw genome → accurate gene models.
Deep learning + HMM, published in @natmethods.nature.com
www.nature.com/articles/s41...
No RNA-seq.
No protein homology.
No repeats, hints, or curated evidence.
Raw genome → accurate gene models.
Deep learning + HMM, published in @natmethods.nature.com
www.nature.com/articles/s41...
Reposted by Schmitt-Lab@HHU
📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Postdoc (m/f/d) in Endosymbiosis Research
karriere.hhu.de
November 25, 2025 at 11:21 AM
📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Reposted by Schmitt-Lab@HHU
✨X-ray crystallography reveals surprising twist in how proteins enter the unique photosynthetic organelles of Paulinella. The chromatophore targeting peptide (crTP) folds into a 3D structure, hinting that folded proteins cross peptidoglycan and inner membrane. (1/2)
academic.oup.com/plphys/artic...
academic.oup.com/plphys/artic...
November 1, 2025 at 7:34 AM
✨X-ray crystallography reveals surprising twist in how proteins enter the unique photosynthetic organelles of Paulinella. The chromatophore targeting peptide (crTP) folds into a 3D structure, hinting that folded proteins cross peptidoglycan and inner membrane. (1/2)
academic.oup.com/plphys/artic...
academic.oup.com/plphys/artic...
New publication in J Mol Biol
New insights in to the function of the CLD and the entire hemolysin secretion machinery. Thanks to Holger Gohlke’s lab and CSS for the wonderful collaboration. Congrats to Sakshi and Cigdem!
New insights in to the function of the CLD and the entire hemolysin secretion machinery. Thanks to Holger Gohlke’s lab and CSS for the wonderful collaboration. Congrats to Sakshi and Cigdem!
October 26, 2025 at 9:54 AM
New publication in J Mol Biol
New insights in to the function of the CLD and the entire hemolysin secretion machinery. Thanks to Holger Gohlke’s lab and CSS for the wonderful collaboration. Congrats to Sakshi and Cigdem!
New insights in to the function of the CLD and the entire hemolysin secretion machinery. Thanks to Holger Gohlke’s lab and CSS for the wonderful collaboration. Congrats to Sakshi and Cigdem!
Reposted by Schmitt-Lab@HHU
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 2:06 PM
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Reposted by Schmitt-Lab@HHU
New WHO report finds 1 in 6 bacterial infections were resistant to antibiotic treatments.
Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health.
Read more 👉bit.ly/438Ta1u
Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health.
Read more 👉bit.ly/438Ta1u
October 14, 2025 at 6:19 AM
New WHO report finds 1 in 6 bacterial infections were resistant to antibiotic treatments.
Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health.
Read more 👉bit.ly/438Ta1u
Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health.
Read more 👉bit.ly/438Ta1u
Reposted by Schmitt-Lab@HHU
This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!
Registration open: 77. Mosbacher Kolloquium "More than lipidic barriers - New horizons in membrane biology" from March 25-28, 2026
lnkd.in/dgsW4c3
Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026
lnkd.in/dgsW4c3
Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026
October 9, 2025 at 6:42 AM
This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!
Reposted by Schmitt-Lab@HHU
Successful #türenauf mit der Maus Event 2025 @hhu.de done and dusted! Thanks to all the helpers @sophieguti.bsky.social @joguti.bsky.social Theo, Sarah, Suny, Lukas, Tom, Rachel, JJChemistry, Hannah and to @markussuta.bsky.social for lending some of his group members to give additional lab tours!
October 3, 2025 at 1:55 PM
Successful #türenauf mit der Maus Event 2025 @hhu.de done and dusted! Thanks to all the helpers @sophieguti.bsky.social @joguti.bsky.social Theo, Sarah, Suny, Lukas, Tom, Rachel, JJChemistry, Hannah and to @markussuta.bsky.social for lending some of his group members to give additional lab tours!
Reposted by Schmitt-Lab@HHU
Molecular structure of the ESCRT III-based archaeal CdvAB cell division machinery www.biorxiv.org/content/10.1101/2025.09.15.676241v1 #cryoem
September 16, 2025 at 7:11 AM
Molecular structure of the ESCRT III-based archaeal CdvAB cell division machinery www.biorxiv.org/content/10.1101/2025.09.15.676241v1 #cryoem
Reposted by Schmitt-Lab@HHU
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:03 PM
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Reposted by Schmitt-Lab@HHU
Science is real
August 31, 2025 at 3:12 PM
Science is real
Reposted by Schmitt-Lab@HHU
🧪 The University of Basel is setting up a new endowed professorship in #ClimateBiophysics at the @biozentrum.unibas.ch, funded by the Georg H. Endress Foundation. This new professorship strengthens climate research @unibas.ch. www.biozentrum.unibas.ch/news/detail/...
New endowed professorship strengthens climate research at the University of Basel
The University of Basel is setting up a new endowed professorship at the Biozentrum to make fundamental discoveries at the interface between biophysics and climate-relevant environmental biology. This...
www.biozentrum.unibas.ch
August 26, 2025 at 7:10 AM
🧪 The University of Basel is setting up a new endowed professorship in #ClimateBiophysics at the @biozentrum.unibas.ch, funded by the Georg H. Endress Foundation. This new professorship strengthens climate research @unibas.ch. www.biozentrum.unibas.ch/news/detail/...
Reposted by Schmitt-Lab@HHU
Was lucky to see this presented at the NYC cryoEM meeting earlier this year - super cool stuff!
August 22, 2025 at 9:37 PM
Was lucky to see this presented at the NYC cryoEM meeting earlier this year - super cool stuff!
Reposted by Schmitt-Lab@HHU
Coming out in @NaturePlants today (rdcu.be/eBScJ): The mechanism for essential amino acid transport across the chloroplast envelope. We identified RETICULATA1 (RE1) as a new type of transport protein. #PlantScience #AminoAcidTransport #Chloroplasts. @franzikuhnert.bsky.social @weberlab.bsky.social
August 22, 2025 at 12:03 PM
Coming out in @NaturePlants today (rdcu.be/eBScJ): The mechanism for essential amino acid transport across the chloroplast envelope. We identified RETICULATA1 (RE1) as a new type of transport protein. #PlantScience #AminoAcidTransport #Chloroplasts. @franzikuhnert.bsky.social @weberlab.bsky.social
Reposted by Schmitt-Lab@HHU
We are hiring a Postdoc in membrane protein cryo-EM at the University of Georgia. Looking for candidates with expertise in membrane protein purification and biochemistry. Fully funded for up to 5 years. Join us in Athens, GA. Apply: [email protected]
August 21, 2025 at 2:26 PM
We are hiring a Postdoc in membrane protein cryo-EM at the University of Georgia. Looking for candidates with expertise in membrane protein purification and biochemistry. Fully funded for up to 5 years. Join us in Athens, GA. Apply: [email protected]