Solar Orbiter’s widest high-resolution view of the Sun

People often misunderstand evolution, particularly its lack of intention, how quickly it can happen, and the fact it's still happening to us.

The FDA has fast tracked Precision’s lead in vivo gene editing program, PBGENE-HBV, designed to cure chronic hepatitis B by eliminating cccDNA.

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Whitehead Institute scientists have been uncovering the roles of regulatory RNA in controlling gene expression

A combination of imaging techniques reveals how herpes simplex virus type 1 assembles within infected cells, highlighting the roles of essential viral proteins in viral assembly and exit.

There has been enormous debate regarding the possibility of a link between childhood vaccinations and the subsequent development of autism. This has i…

Sleeping naked comes with all sorts of unexpected positives. Here's a look at all the surprising things that can happen when you start sleeping in the buff.

A key protein network that keeps cells safe from the dangerous effects of transposable elements has been uncovered.

Missense variants that change the amino acid sequences of proteins cause one-third of human genetic diseases1. Tens of millions of missense variants exist in the current human population, and the vast majority of these have unknown functional consequences. Here we present a large-scale experimental analysis of human missense variants across many different proteins. Using DNA synthesis and cellular selection experiments we quantify the effect of more than 500,000 variants on the abundance of more than 500 human protein domains. This dataset reveals that 60% of pathogenic missense variants reduce protein stability. The contribution of stability to protein fitness varies across proteins and diseases and is particularly important in recessive disorders. We combine stability measurements with protein language models to annotate functional sites across proteins. Mutational effects on stability are largely conserved in homologous domains, enabling accurate stability prediction across entire p

ABSTRACT. JWST provides a view of the Universe never seen before, and specifically fine details of galaxies in deep space. JWST Advanced Deep Extragalactic