That's one cursed colour scheme for anyone who has learned a little chemistry 😂

My protein crystals getting imaged by the Formulatrix Rock Imager. I think it's pretty awesome! 🥰
And convenient to be able to check the images from my desk, including time points to check growth. Beats sitting at a microscope where you can't drink tea! ☕
#Crystallography #ResearchComplexAtHarwell

They resealed the electron storage ring of the synchrotron @diamondlightsource.bsky.social during shutdown to get it ready for more experiments!

This week I harvested about 450 beautiful protein crystals, more than in my 7 previous years of crystallography! These are crystals of a Covid target in which I soaked promising drug fragments to see what binds and how.

I started a new job at @diamondlightsource.bsky.social! A 2nd protein crystallography postdoc, this time for antiviral drug discovery 🤩
It's only funded until October this year, but I'm sure I'll find something else after that 😁

I'm particularly interested in how these properties in cytochromes P460 are affected by the unusual heme-protein crosslinking. This makes them green, distorts the heme and allows them to oxidise the iron-bound NH2OH to N2O, a greenhouse gas. This is basically what makes them #P460 instead of #P450!

Hello, can I be added? I'm a biochemist currently making cool protein structures.
Fresh pre-print on the discovery a new heme modification: www.biorxiv.org/content/10.1...
Me: orcid.org/0000-0003-05...
More papers to come! And I do good SciComm 😁

Hello new followers! 👋
I'm a structural biologist 🧶🧬 currently having fun with unusual kinds of protein crystallography 💎 at Diamond Light Source. 😀
But my 3 years are almost over... 😢
So I'm looking for a lab-based biochemistry job 🧪 in the Oxford area. If you have any leads, please get in touch! 😁

I do like the phase biased cat! It helps understand why we have to do iterative building and beware of what looks suspiciously like the starting model.
www.ysbl.york.ac.uk/~cowtan/four...

Iris in CCP4i2 is very useful to find amino acid residues that are particularly more mobile at room temperature than in cryogenic conditions! #protein #crystallography 🧪
@glycojones.bsky.social I assume that's not the use you had in mind when leading its development? 😁
🧶🧬

Making this green protein has been pretty great 🧪 Easy to find it and estimate concentration!
But can you guess WHY it's green? 😋
🧶🧬

Blink and you might miss it moving!
The Scorpion is my current favourite instrument. It can make my 96 conditions (2D gradient of concentrations) in half an hour. And look SUPER COOL doing it! 😆
#crystallography 🧪

I inherited some dissolved metals from my colleague Peter Smyth and I think they're very pretty 🤩
We use them for long cultures of bacteria, so they don't run out of metal ions when making our favourite proteins 😊