Hans Pfalzgraf
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scihans.bsky.social
Hans Pfalzgraf
@scihans.bsky.social
Research Scientist at ProImmune. Biochemistry to help make Ankyron® protein binders. Former crystallographer. I love #SciComm, #Sustainability, #Climbing and #EDM. Views are my own. He/Him.
Came for the insightful, funny one-liners; stayed for the insightful, not-funny academic papers
November 14, 2025 at 6:38 PM
The work was challenging, but it seems like the dream job: it's fun, yet could also help save some of the tens of thousands of lives lost every year to this disease.
April 17, 2025 at 5:39 PM
Can I be added if I'm a postdoc in protein X-ray crystallography? 😁
April 2, 2025 at 11:52 AM
Oh yeah I once lost a grid and found it again this way 😂
April 2, 2025 at 11:49 AM
Thanks to all the authors for getting this through, especially Hannah who did most of the work!
@mikehough.bsky.social
March 27, 2025 at 4:21 PM
I'm particularly interested in how these properties in cytochromes P460 are affected by the unusual heme-protein crosslinking. This makes them green, distorts the heme and allows them to oxidise the iron-bound NH2OH to N2O, a greenhouse gas. This is basically what makes them #P460 instead of #P450!
March 27, 2025 at 4:21 PM
Wow congatulations @cristobaluauy.bsky.social !
February 13, 2025 at 4:19 PM
For the record, I ended up using BANΔIT as it does the B-factor normalisation for you!
Run it here: bandit.uni-mainz.de
Paper: doi.org/10.1002/minf...
BANΔIT: B’-factor analysis for drug design and structural biology
Online B-factor normalization
bandit.uni-mainz.de
January 13, 2025 at 11:48 AM
🤣
January 13, 2025 at 11:43 AM
Thank you so much for adding me!
My supervisor @mikehough.bsky.social came up with the title 😁
January 10, 2025 at 5:26 PM
Hello, can I be added? I'm a biochemist currently making cool protein structures.
Fresh pre-print on the discovery a new heme modification: www.biorxiv.org/content/10.1...
Me: orcid.org/0000-0003-05...
More papers to come! And I do good SciComm 😁
January 6, 2025 at 3:24 PM
Good idea, but actually not the same porphyrin nor the same ion 😋
December 9, 2024 at 11:25 AM
Thanks James 😁
December 9, 2024 at 11:23 AM
🤣
December 6, 2024 at 3:40 PM
I'll give a hint: there's iron in it 😁
December 6, 2024 at 3:33 PM