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Reposted by Sean Flynn

Di Antonio Research Group @diantoniogroup.bsky.social · 20d

We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇

www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Reposted by Sean Flynn

Surfin' NuRD @surfinnurd.bsky.social · Aug 30

Check it out, Chromatin Kids!

Chromatin remodeller does stuff to Transcription Factors!

Functions where it is seldom seen!

Both decreases and increases chromatin accessibility!

How cool is that?

bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · Aug 30

The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers https://www.biorxiv.org/content/10.1101/2025.08.29.672645v1

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Sean Flynn @seanflynn.bsky.social · Sep 2

Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models

gw4biomed.ac.uk/architects-o...

gw4biomed.ac.uk/risk-vs-prot...

gw4biomed.ac.uk/rna-dependen...

gw4biomed.ac.uk/investigatin...

Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders - GW4 BioMed MRC DTP

Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Sum...

gw4biomed.ac.uk

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Reposted by Sean Flynn

W. Brent Derry @wbderry.bsky.social · Jul 16

Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...

Giant study finds a research field that’s mostly reproducible

Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.

www.nature.com

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Reposted by Sean Flynn

Krzysztof Herka @kherka.bsky.social · Jun 4

How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function?

In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...

DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers - Genome Biology

Background Enhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer–promoter interaction are incompletely understood. G-quadruplex...

doi.org

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Reposted by Sean Flynn

Pradeepa Madapura @pradeepmadapura.bsky.social · Jun 3

Happy to be part of this exciting work. A must-read for enhancer aficionados: A massive effort has gone into generating genome-wide STARRseq in hPSCs and conducting functional validation assays. Congratulations to all authors, Stefan and Ufuk, for leading this project 🎉.

Stefan Schoenfelder @stefanschoenfelder.bsky.social · Jun 2

Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social‬:
www.biorxiv.org/content/10.1...

🧵 below

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells

Enhancers are key gene regulatory elements that ensure the precise spatiotemporal execution of developmental gene expression programmes. However recent findings indicate that approaches to identify en...

www.biorxiv.org

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Reposted by Sean Flynn

Surfin' NuRD @surfinnurd.bsky.social · May 8

Please get in touch if you want to apply for this to work with me on chromatin remodellers, enhancers and lineage commitment in mammalian stem cells at @lsiexeter.bsky.social

European Commission @ec.europa.eu · May 8

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

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Reposted by Sean Flynn

Clem Bernard @clembrnrd.bsky.social · Apr 25

I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀

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Reposted by Sean Flynn

Clem Bernard @clembrnrd.bsky.social · Apr 17

Job alert 🚨 We are hiring a research assistant!

This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.

Please spread the word!

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Reposted by Sean Flynn

Yaser Atlasi @yatlasi.bsky.social · Mar 31

We have a postdoc position in my group in collaboration with EMBL Rome; join us to make important discoveries in this exciting project.
Please apply or share.

hrwebapp.qub.ac.uk/tlive_webrec...

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Reposted by Sean Flynn

All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Mar 24

We are very excited to launch the registration for our 2025 symposium on 'Chromatin, Epigenetics and Transcription' today!

Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters!

allirelandchromatinconsortium.ie/annual-meeti...

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Sean Flynn @seanflynn.bsky.social · Mar 3

We have a funded PhD position available in Exeter @exeter.ac.uk
Gene Regulation in Brain Development and Disease 🧬
Please share / repost

www.exeter.ac.uk/study/fundin...

Award details | Funding and scholarships for students | University of Exeter

www.exeter.ac.uk

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Reposted by Sean Flynn

Inês Barroso @inesbarroso.bsky.social · Dec 16

jobs.exeter.ac.uk/hrpr_webrecr...
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!

Powered by MHR

jobs.exeter.ac.uk

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Sean Flynn @seanflynn.bsky.social · Dec 11

Thread below on @robinburns.bsky.social et Al’s new paper #evobio #plantscience 🌱

robinburns.bsky.social @robinburns.bsky.social · Dec 11

Happy to share our preprint on our favourite polyploid hybrid, Arabidopsis suecica. We examine the evolutionary cycle of polyploidy in this young allotetraploid, focusing on three key parts of the cycle: origin, meiotic adaptation and rediploidization

bioRxiv Genomics @biorxiv-genomic.bsky.social · Dec 10

Diploid origins, adaptation to polyploidy, and the beginning of rediploidization in allotetraploid Arabidopsis suecica https://www.biorxiv.org/content/10.1101/2024.12.06.627142v1

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Sean Flynn @seanflynn.bsky.social · Nov 22

If you are interested in #Epigenetics apply for a PhD with Jack Hardwick and Jonathan Hanley in Bristol, and our group in Exeter.

Elucidating the role of DNA modifications in neurons
Funded by #SWBio DTP
Deadline: Dec 4
To apply: www.swbio.ac.uk/programme/ho...

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Reposted by Sean Flynn

All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Nov 19

Nice to see all you chromatin & epigenetics aficionados here! As we build our network back up please repost details for our upcoming webinar this Friday!

We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇

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Reposted by Sean Flynn

Surfin' NuRD @surfinnurd.bsky.social · Nov 7

Fully funded #PhD Studentship with myself and JJ Phillips at the Living Systems Institute, @uniofexeter.bsky.social

"Control of chromatin remodeller activity to direct cell fate decisions"

#Chromatin #Transcription #StemCells #StructuralBiology

Please re-skeet!

www.exeter.ac.uk/research/ins...

LSI PhD programme | Living Systems Institute | University of Exeter

www.exeter.ac.uk

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Sean Flynn @seanflynn.bsky.social · Nov 14

Welcome @kherka.bsky.social, who is working on chromatin and G4s

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Sean Flynn @seanflynn.bsky.social · Nov 11

Exciting!