How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

www.biorxiv.org/content/10.1...

Naz's preprint is out and she is looking for a postdoc!
🔬
Enthusiastic. Smart. Hard working. Top lab citizen. Explain models of transcription with Oscar-deserving gestures. Hire Naz!

I am hiring for a research technician role in my new lab at UC Irvine studying how transcription factors control cell identity. If you know any graduating undergrads or postbacs looking for a position, please spread the word! Apply by May 9 for full consideration. recruit.ap.uci.edu/JPF09594

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...

My alma mater, the University of British Columbia, Dept of Medical Genetics, is hiring for a tenure track junior faculty position specializing in chromatin regulation / gene regulatory mechanisms. Beautiful city and vibrant epigenetics research. Please share!

medgen.med.ubc.ca/assistant-pr...

WHERE WILL YOU BE ON MARCH 7TH!?

Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!

#standupforscience2025

Before I start, let me thank the brave folks within NIH who have shared information, hints, and other materials that have helped me sort this out. I don’t know most of your names and, even if I did, no one would ever hear them from me.

So here is what appears to be going on…

1/n

Good news (for now) www.nytimes.com/2025/02/10/u...

Thanks, you too!

Friends, we have a school-wide search for an open rank faculty as mentor professor. It is a unique position that can be hired in a variety of departments across the school. Please check it out and share widely.

recruit.apo.ucla.edu/JPF10062

Just received notice that my NIH study section next week has been cancelled. It has nothing to do with DEI and will have a negative impact on critical cancer research.

NIH council meeting (NIDCR)scheduled for today, where our R01 grant (3rd percentile) was supposed to be discussed, was postponed indefinitely as a consequence of Trump's executive order which ordered pausing of all communications from all federal agencies. Not good.

I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...

A great opportunity to start your own research group

@pasteur.fr in Developmental Biology👇
research.pasteur.fr/fr/call/call...

Multiscale footprints reveal the organization of cis-regulatory elements www.nature.com/articles/s41...
▶️Footprints of DNA–protein interactions from bulk & single-cell ATAC-seq ⤵️
▶️Deep learning to infer transcription factor and nucleosome binding
▶️Age-associated reduction of nucleosome footprints

Thank you!

Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org