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shinuoweng.bsky.social
Shinuo Weng
@shinuoweng.bsky.social
520 followers 500 following 19 posts
Uncovering the mechanics of life, one cell at a time | https://sweng.wse.jhu.edu/
sweng.wse.jhu.edu
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Reposted by Shinuo Weng
jbwallingford.bsky.social
John Wallingford @jbwallingford.bsky.social · Jul 14
Last chance to tell the NIH if you think animal models are important for biomedical research! 👇👇👇👇
jbwallingford.bsky.social
John Wallingford @jbwallingford.bsky.social · Jul 11
The NIH is asking scientists and the public to comment on plans to drastically limit animal model research. If you think animal models remain important tools for basic and clinical research tell them! Click the link below and scroll down to send your comments!

www.fda.gov/news-events/...
FDA-NIH Workshop: Reducing Animal Testing
The FDA is hosting a workshop on reducing animal testing. The workshop is open to current FDA and NIH employees.
www.fda.gov
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Jul 4
Excited to grow our team! The Tissue Morpho and Mechanics Lab at Hopkins is seeking a full-time Lab Technologist (50% lab tech + 20% lab manager + 30% scientist) to support our research in developmental biology and biomechanics 🐸🖖🔬🧪🫵. Great opportunity to be part of a vibrant and curious group.
Research Technologist
Research Technologist
jobs.jhu.edu
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Reposted by Shinuo Weng
jbwallingford.bsky.social
John Wallingford @jbwallingford.bsky.social · May 30
What a fantastic essay by last year's @mblscience.bsky.social Embryology students! A perfect paean to the most wonderful science: "It's exhausting; it's exhilarating; it's Embryology."

journals.biologists.com/dev/article/...
Embryology 2024: a summer like no other
Each summer since 1893, a small group of scientists from around the world have convened at the Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, USA, to work on the most exciting model ...
journals.biologists.com
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Apr 11
Hi everyone! I'm offering a new course, Introduction to Mechanobiology, for upper-level undergraduates and new graduate students in engineering. I'm seeking a textbook and resources for teaching. If you've taught a similar course or have recommendations, I'd love to hear your suggestions. Thank you!
Reposted by Shinuo Weng
mskcancercenter.bsky.social
Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · Apr 3
MSK's Dr. Alexandra Joyner is hanging up her lab coat following an illustrious 40-plus-year career. When asked what advice she has for new scientists, she shares: "You have to decide: Why are you going into this career? And then you have to stay true to that." Learn more about her legacy & impact ⬇️
Looking Back, Looking Ahead With MSK Developmental Biologist Alexandra Joyner
Developmental biologist Dr. Alexandra Joyner reflects on her career and talks about the new passions she looks forward to pursuing in retirement.
www.mskcc.org
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Reposted by Shinuo Weng
rashmi-priya.bsky.social
Rashmi Priya @rashmi-priya.bsky.social · Mar 10
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Mar 21
Interaction between two cells is necessary and sufficient to initiate PCP sorting😀, as shown by Lena P. Basta, Bradley W. Joyce, Dr. Eszter Posfai @eposfai.bsky.social , and Dr. Danelle Devenport. Here is the article. www.science.org/doi/10.1126/...
Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous
For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...
www.science.org
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Mar 21
R.I.P.... Dr. Michael Sheetz was a pioneer in mechanobiology. The review paper by Dr. Viola Vogel and Dr. Sheetz, published in 2006, was one of the first review articles I read when I started my Ph.D.
jcb.org
Journal of Cell Biology @jcb.org · Mar 21
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Jan 29
Are they bicoid and caudal? How did the 17th Century Tibet get this????AMAZING!
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Dec 9
X. Mess Party fires on to celebrate the end of the first semester! Thank you all for your commitments to do the hard work!!!
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Reposted by Shinuo Weng
jamesbriscoe.bsky.social
James Briscoe @jamesbriscoe.bsky.social · Dec 4
Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows

Know a #devbio post-doc about to enter the academic job market?

Would they benefit from a little support & mentoring?

Spread the word

Deadline 31 Jan 2025

journals.biologists.com/dev/pages/pi...
PI programme | Development | The Company of Biologists
PI programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our call for our Pathway to Independence program...
journals.biologists.com
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Reposted by Shinuo Weng
akallen10.bsky.social
Anna Allen @akallen10.bsky.social · Dec 4
Our IOS Virtual Office Hour this month is on what to do post-review with your individual reviews, panel summary & Program Officer comments. December 19th from 1-2pm ET. We'll share valuable info for anyone about the merit review process. See you there!

iosblog.nsfbio.com/2024/12/04/d...
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Dec 3
😅Please add me to both "morphogenesis" and "collective cell migration". Thank you, Maik!
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Reposted by Shinuo Weng
carstenschulte4.bsky.social
Carsten Schulte @carstenschulte4.bsky.social · Nov 12
If you're searching for the Mechanobiology community and starter pack, here it is:

Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word.
go.bsky.app/G5cQqYT
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Reposted by Shinuo Weng
maikbischoff.bsky.social
Maik Bischoff @maikbischoff.bsky.social · Nov 19
Even though there are great #devbio and #biophysics starter packs, I felt #morphogenesis & #organogenesis was missing as a subfield :D

Far from complete or full. Tell me if you want to be added!
go.bsky.app/PB6s8PQ
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Dec 3
Hi Maik, Thanks very much for creating the starter packs. Could you please add me?
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Reposted by Shinuo Weng
deniswirtz.bsky.social
Denis Wirtz @deniswirtz.bsky.social · Dec 3
Hopkins faculty: Need editorial assistance for a proposal or an article? Make use of our services at no charge.

Contact my office here: research.jhu.edu/rdt/easi/

Happy writing!
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Dec 2
Follow and spread the word please🐸🪰🐟🐭🪱🦋🐙🏄‍♀️🔬🌱🦠🥣🐣
maikbischoff.bsky.social
Maik Bischoff @maikbischoff.bsky.social · Nov 27
There are so many #morphogenesis researchers here!
My first starter pack is full!
Here is Part 2: go.bsky.app/K6YYKeC

#devbio #cellbio #science

Tell me if I should add you but try to make sure, that you're not already in Part 1.
I cannot cross-reference everyone 😅

Part 1: go.bsky.app/RzDD9or
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Nov 30
Last but not least, huge thanks to all co-authors, Dr. Yasuhiro Inoue, Masaya Hayashi, and Dr. John Wallingford @jbwallingford.bsky.social . Special thanks to the editor, Dr. Deborah Taylor, for her guidance, and the reviewers for their invaluable feedback.
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Nov 30
Figure 6: When scaling up to tissues, CE spreading and propagation are essential. In Arvcf-deficient tissue, disrupted t-junction rotation is correlated to localized and discontinuous convergence, showcasing an impaired multiscale mechanical synergy at play.
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Nov 30
Figure 5: Using a dynamic vertex model, we found that a single t-junction rotation can trigger cascading cell intercalations, spreading CE across the tissues. A biomechanical domino effect!
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Nov 30
Figure 4: Our static toy models reveal how perpendicular t-junctions block force coupling and propagation, demonstrating how microscale defects escalate to large-scale abnormalities.
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Nov 30
Figure 3: Our previous work on Arvcf revealed its role in maintaining cell cortex tension. Interestingly, Arvcf depletion delays t-junction rotation, leading to many more perpendicular t-junctions. This subtle change in cell packing is indeed akin to a “traffic jam”.
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Nov 30
Figure 2: T-junction rotation is driven by a “four-way tug-of-war” between tensions on connected v-junctions. We employed a non-invasive image-based analysis to confirm this tension-based mechanism. Please stay tuned for more details on this method.
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shinuoweng.bsky.social
Shinuo Weng @shinuoweng.bsky.social · Nov 30
Figure 1: Here we focused on the overlooked resolution phase of cell intercalation—highlighting t-junction extension and rotation, described in vertebrates for the first time.
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