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Reposted by Shyama Nandakumar

Society for Developmental Biology @socdevbio.bsky.social · Sep 3

The 2025-2026 season of the Ethel Browne Harvey Postdoc Seminar kicks off Friday, September 12 at 3 pm Eastern Time with @sarahcolijn.bsky.social‬ of Washington Univ in St. Louis and @shyama13.bsky.social‬ of the Univ of Pittsburgh. Register today and join us. bit.ly/4649fWS #SDBPostdocSeminar

Society for Developmental Biology Ethel Browne Harvey Postdoctoral Seminar Series
Friday, September 12, 2025, 3:00pm - 4:00 pm Eastern Time
Sarah Colijn (Washington University in St. Louis)
Novel roles for centriolar protein WDR90 in endothelial cells and cardiac tissue
Shyama Nandakumar (University of Pittsburgh)
Ring canals in the larval adipose of Drosophila buffer stress response

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Reposted by Shyama Nandakumar

Genetics Society of America @genetics-gsa.bsky.social · Sep 2

Today we celebrate 1945 GSA President & Nobel laureate Barbara McClintock. Continue her legacy—nominate for the 2026 GSA Awards by Oct 1, 2025.

🔗 buff.ly/bIdKqcw

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Lesley Weaver @lesleynweaver.bsky.social · Aug 26

My lab’s newest preprint is now available.

www.biorxiv.org/content/10.1...

Adipocyte-Derived Amino Acid Storage Proteins are Required for Germline Stem Cell Maintenance in Adult Drosophila Females

Tissue homeostasis is dependent on precise coordination between endocrine organs in response to changes in organism physiology. Secreted circulating factors from adipocytes (called adipokines) regulat...

www.biorxiv.org

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Shefali @iamshef.bsky.social · Jul 21

The #Flyboard and #FlyCROSS committee including me, Laurel @shyama13.bsky.social @jocmcdonald.bsky.social @frankmac.bsky.social @armstrongflylab.bsky.social & Jonathan look forward to having you on board.

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Lydia Grmai, Ph.D. @lydiagrmai.bsky.social · Jul 15

new review alert❗️

thought your neighborhood stress response pathway (ISR) only dealt in stress adaptation? well, maybe so. but many cells are apparently quite “stressed out” - even healthy ones.

see quoted thread by my phenom co-author @shyama13.bsky.social for a summary! ⬇️

Shyama Nandakumar @shyama13.bsky.social · Jul 15

Hello fellow scientists, I'm thrilled to share with you a state of the art review that @lydiagrmai.bsky.social , the bsky-less Deepika Vasudevan and I have been working on for >1 year! Keep reading...!
febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress-adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of l....

febs.onlinelibrary.wiley.com

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Shyama Nandakumar @shyama13.bsky.social · Jul 15

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What are the consequences of persistent ISR activation in tissues that use ISR for homeostatic functions?

How does ISR regulate cellular biomechanical changes?

Is "turning off" ISR also a necessary for homeostasis?

Read more here and please RT! febs.onlinelibrary.wiley.com/doi/10.1111/...

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Shyama Nandakumar @shyama13.bsky.social · Jul 15

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Several open questions remain, and we discuss each of the following to close out this review:

Is ISR a master regulator of metabolism?

Does it regulate "cellular memory"?

How do homeostatic and adaptive ISR functions differ in the same tissue?

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Shyama Nandakumar @shyama13.bsky.social · Jul 15

5/ We found some interesting clues that suggest ISR could play an important role in influencing the robustness of various biological oscillators, across different time scales! (something yours truly is excited to investigate further!)

a white fan is sitting on a red table .

ALT: a white fan is sitting on a red table .

media.tenor.com

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Shyama Nandakumar @shyama13.bsky.social · Jul 15

4/ Is ISR a driver of physiological aging? - we highlight emerging literature that suggests this is the case in the nervous system and skeletal system

an elderly woman is driving a car next to a dog

ALT: an elderly woman is driving a car next to a dog

media.tenor.com

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Shyama Nandakumar @shyama13.bsky.social · Jul 15

3/ We highlight several known key functions of ISR in development, metabolic tissue function, tissue surveillance and cell competition...but there's more! We identified some emerging themes that could inform decades of future "stress" research"...some highlights 👇👇👇

a swiss army knife with a red handle and a white cross on it

ALT: a swiss army knife with a red handle and a white cross on it

media.tenor.com

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Shyama Nandakumar @shyama13.bsky.social · Jul 15

2/ Our favourite stress signaling pathway, the Integrated Stress Response (ISR) moonlights in several tissues playing several critical homeostatic functions, across species!

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Shyama Nandakumar @shyama13.bsky.social · Jul 15

Hello fellow scientists, I'm thrilled to share with you a state of the art review that @lydiagrmai.bsky.social , the bsky-less Deepika Vasudevan and I have been working on for >1 year! Keep reading...!
febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress-adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of l....

febs.onlinelibrary.wiley.com

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Reposted by Shyama Nandakumar

Saccharomyces Genome Database @yeastgenome.bsky.social · Jun 9

FlyBase needs your help!

Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org

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Shyama Nandakumar @shyama13.bsky.social · Jun 11

New paper alert.

The fat body in Drosophila larvae is comprised of pairs of adipocytes that are connected to one another throughout larval development! Ring canals here are v.v.small, allow selective organellar cargo transport, mediate stress tolerance and more....!

Full thread coming soon!

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jun 11

Ring canals in the larval adipose of Drosophila buffer stress response https://www.biorxiv.org/content/10.1101/2025.06.11.658881v1

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jun 11

Ring canals in the larval adipose of Drosophila buffer stress response https://www.biorxiv.org/content/10.1101/2025.06.11.658881v1

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Buttitta Lab @buttittalab.bsky.social · Jun 5

Thank you for the highlight of our work! #drosophila #cancer model.

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · Jun 5

Probing Prostate Cancer: Adult male fruit fly accessory gland-cancer as a model for studying human prostate cancer

Image made with @leicamicrosystems.bsky.social
microscopy
📷 S. Jaimian Church, @buttittalab.bsky.social et al
@umich.edu in @dmmjournal.bsky.social

➡️ bpod.org.uk/archive/2025...

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Shefali @iamshef.bsky.social · Jun 2

Hey #Drosophila folks ! #FlyCROSS is back and #Mentor surveys are open NOW ! If you're a faculty/postdoc/ equivalent in any scientific career & have #Drosophila research experience - we'd be delighted to have you as mentors to empower early career scientists in the #Dros community !

Summer 2025 Survey For Mentors : FlyCROSS Mentor Mentee Matching Program

We appreciate you taking the time and volunteering to be a mentor! Add [email protected] to your email address book or safe sender list, so that you can receive our emails. To be a participating me...

docs.google.com

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Harmit Singh Malik @harmitmalik.bsky.social · Mar 21

Drosophila folks at the @genetics-gsa.bsky.social Fly meeting please take some time to thank the amazing organizers who put in a lot of hard work:
genetics-gsa.org/drosophila-2...

Special thanks to GSA folks especially the tireless Suzy Brown (who appears to run entirely on diet Mountain Dew)

Organizers - 66th Annual Drosophila Research Conference

Visit our website to learn more.

genetics-gsa.org

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Prof Jess @pr0fjess.bsky.social · Mar 20

Really looking forward to this workshop!

Shyama Nandakumar @shyama13.bsky.social · Mar 20

#Dros25 workshop alert!
Today at 8pm, Pacific Ballroom C - Go Big or Go Home : Polyploidy on the Fly.
Excited to host this with @gavinrrice.bsky.social

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Shyama Nandakumar @shyama13.bsky.social · Mar 20

#Dros25 workshop alert!
Today at 8pm, Pacific Ballroom C - Go Big or Go Home : Polyploidy on the Fly.
Excited to host this with @gavinrrice.bsky.social

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Shefali @iamshef.bsky.social · Mar 11

The committee has unanimously voted to have the next cycle in summer/early fall - so early career scientists, keep an eye out for announcements !!! 👀

If you have suggestions/ideas for the future cycles, please feel free to reach out !!

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Alissa Armstrong @armstrongflylab.bsky.social · Mar 11

#drosophila #mentoring

Shefali @iamshef.bsky.social · Mar 11

#Drosophila community update: As the #First cycle of FlyCROSS is coming to completion, time for celebrations! We matched 37 mentees to their preferred mentors 🎉🥳

This year we had 90 mentor volunteers from across the world. Distributions of mentor demographics and types of support are shown here:

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Shyama Nandakumar @shyama13.bsky.social · Feb 26

#Drosophila folks, anyone looking for a roommate (Female) at fly meeting? I know someone who would appreciate a roommate. Comment/DM for details

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Shyama Nandakumar @shyama13.bsky.social · Feb 25

Congratulations!!!! 🎉🎉🎉

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Alissa Armstrong @armstrongflylab.bsky.social · Feb 24

Beyond thrilled - I’ve been awarded an NSF CAREER grant! I get to continue making scientific discoveries, training the next generation of researchers, & sharing knowledge about the scientific enterprise with the general public. This support is much needed, personally & professionally…let’s GOOO!!!

Screenshot of part of a notice of award for an NSF CAREER grant: Regulation of Drosophila melanogaster oogenesis by ovarian and adipose tissue amino acid sensing signaling pathways

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