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Amanda Sierra

@sierralab.bsky.social

900 followers 210 following 57 posts

Research professor at Achucarro Basque Center for Neuroscience. Microglial lover, passionate about science outreach. ORCID: 0000-0001-8415-096X Lab website: https://www.achucarro.org/es/laboratory/glial-cell-biology/

www.achucarro.org

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Amanda Sierra @sierralab.bsky.social · Dec 11

Happy to share our Perspective on #microglia #pruning and help to answer the questions of whether they are hunters or gatherers of brain #synapses 🧠🧪

#neuroskyence
nature.com/articles/s4159…

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Amanda Sierra @sierralab.bsky.social · Sep 4

🧠🧪Funded PhD job offer ok neddylation in glial cells @achucarro.bsky.social

Pls repost

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Amanda Sierra @sierralab.bsky.social · Aug 13

Join us if you want to learn about #microglia!

Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · Aug 11

🗓️El próximo 16 de septiembre a las 16h "Webinar Grupo Neurobiología Molecular" coordinado por @pgonzalezrodriguez.bsky.social

🗣️ @sierralab.bsky.social “Brain scavengers: microglial phagocytosis in health and disease

✍️ https://f.mtr.cool/fawelesych

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Amanda Sierra @sierralab.bsky.social · Aug 8

"Sisterly love"
Proliferating neural stem cells🧪🧠

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Amanda Sierra @sierralab.bsky.social · Jul 24

Are you interested in human brain #organoids to study #microglia but don't know where to start?🧠🧪
#neuroskyence

Here's our piece of advice on "Building Immunocompetent Cerebral Organoids From a Developmental Perspective"

onlinelibrary.wiley.com/doi/10.1002/...

Building Immunocompetent Cerebral Organoids From a Developmental Perspective

Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statist...

onlinelibrary.wiley.com

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Reposted by Amanda Sierra

Ʌʗʜʋʗɑɼɼʘ @achucarro.bsky.social · Jul 14

The @sierralab.bsky.social lab is hiring!

Postdoctoral position in #microglial development (#IKUR)

www.achucarro.org/job/postdoct...

Amanda Sierra @sierralab.bsky.social · Jul 11

Reaching Marseille was quite an odissey because of the wildfires, but the #Euroglia meeting was quite a success! Tons of science, friends and fun!

Reposted by Amanda Sierra

Ʌʗʜʋʗɑɼɼʘ @achucarro.bsky.social · Jun 2

@sierralab.bsky.social reflexiona sobre si se puede parar la #menopausia

www.elcorreo.com/vivir/salud/...

¿Y si pudiéramos evitar la menopausia? | El Correo

Se están desarrollando terapias para rejuvenecer los ovarios y evitar los efectos negativos sobre la salud

www.elcorreo.com

Amanda Sierra @sierralab.bsky.social · May 30

Pero cámbiate el handle que no sabía que eras tú!

Amanda Sierra @sierralab.bsky.social · May 30

Congrats dear Alberto! You rock!

Amanda Sierra @sierralab.bsky.social · May 4

This sounds sooo familiar

So, maybe, "The next time we hear a crazy/bitch narrative about a senior woman, let's ask ourselves: How much first-hand evidence do we personally have to back it up -- does it resonate with our own direct observations and interactions with her?"

Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · May 3

“How might the narrative about senior women be challenged or changed in order to respect these women who have achieved enough success to earn promotion? How do we stop this generational cycle so that women's wings aren't clipped as soon as they approach the power to soar.”

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Reposted by Amanda Sierra

Carsen Stringer @computingnature.bsky.social · Feb 12

#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...

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Amanda Sierra @sierralab.bsky.social · Mar 29

Congrats Marisol, you rock!

Reposted by Amanda Sierra

The Transmitter @thetransmitter.bsky.social · Mar 25

Even in the absence of formal instruction to do so, we should continue to hold ourselves and our neuroscience colleagues accountable for “Sex as a Biological Variable” practices, writes @docbecca.bsky.social.

#neuroskyence

www.thetransmitter.org/sex-differen...

Amid NIH upheaval, how to keep sex as a biological variable

Even in the absence of formal instruction to do so, we should continue to hold our colleagues accountable for SABV practices.

www.thetransmitter.org

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Amanda Sierra @sierralab.bsky.social · Mar 15

My heart is with my fellow american scientists... Politics interfering with science at this level is something I could have never expected

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Amanda Sierra @sierralab.bsky.social · Mar 8

Fantastic defense by the ever amazing @martapiglesias.bsky.social! Watch out for more great things to come from her!

Amanda Sierra @sierralab.bsky.social · Mar 8

Thank you Carles!

Reposted by Amanda Sierra

Eric Topol @erictopol.bsky.social · Mar 1

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

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Amanda Sierra @sierralab.bsky.social · Mar 1

Of course, the field has been focused on pruning for too long, disregarding other roles. It's not good for discovery!

Reposted by Amanda Sierra

Nuno Miguel Gonçalves @scinuno.bsky.social · Feb 25

🗣️ℹ️How do we prevent misinformation? By talking about it, without reservations and full openness.

🧫🐁It is the same with science communication and #AnimalResearch specifically.

💉💡Even if you somehow oppose it… know why it is still needed.

EARA @eara.eu · Feb 18

📄 We have updated our popular website information page '40 reasons why animals are needed for #BiomedicalResearch'.

🔬 The page which presents compelling reasons why #AnimalResearch continues to be essential in medical advances & scientific discovery.
www.eara.eu/post/40-reas...

40 reasons why animals are needed – updated EARA page

EARA has updated its popular website information page 40 reasons why animals are needed for biomedical research, which presents compelling reasons, in bitesize form, why the use of animals continues t...

www.eara.eu

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Amanda Sierra @sierralab.bsky.social · Feb 26

Thanks for reaching out! The distinction between hunters or gatherers (culling or scavening) is mechanistic and needs to be experimentally determined. Pruning and gardening are poetic terms but not accurate enough in my opinion. They do not help understanding how microglia actually remove synapses

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Reposted by Amanda Sierra

Federico Soria @soriafn.bsky.social · Feb 4

This is today. No recording, so it won't be available in our website.
Don't miss it!

European Microglia Webinar Series @microgliaseries.bsky.social · Jan 28

📢New webinar coming soon📢
Dr. Gilbert Di Paolo from Denali Therapeutics will be our next speaker on February 4th. Check all the information in the flyer and add it to your calendar!

Reposted by Amanda Sierra

Christian Frezza @frezzalab.bsky.social · Jan 31

I would love to hear your views on this article. I discuss some hurdles I faced when thinking about experiments and projects design. This is something no one formally teaches you.

network.febs.org/posts/thinki...

Thinking like a scientist: not that trivial

network.febs.org

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Amanda Sierra @sierralab.bsky.social · Feb 2

🧪🧠

Shane Liddelow @liddelowsa.bsky.social · Jan 30

#GliaPapers #GliaFebruary2025 RESEARCH

Noelia Rodriguez-Iglesias, …, Simon Gutbier,
@sierralab.bsky.social

Bottom-up approach identifies antipsychotic & antineoplastic trifluoperazine & ribose derivative deoxytubercidin as microglial phagocytosis inhibitors onlinelibrary.wiley.com/doi/10.1002/...

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Reposted by Amanda Sierra

Agnes Nadjar @agnesnadjar.bsky.social · Jan 30

Interested in pursuing a PhD in neuroimmunology and metabolism? Apply to this call to work on a collaborative project between my group and @cmadore.bsky.social !

Charlotte Madore @cmadore.bsky.social · Jan 30

🧠Talented future PhD students in Neuroscience/Nutrition !!! Do not hesitate to apply to this great PhD program at Bordeaux University🧠
(the call ends soon)
🧠🤯🧪

www.bordeaux-neurocampus.fr/phd-call-2025/

Neurocampus PhD program - Call for applications - Bordeaux Neurocampus

Applications are open until 28th February 2025.

www.bordeaux-neurocampus.fr

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Amanda Sierra @sierralab.bsky.social · Jan 29

"Note, for all the seemingly sophisticated thought and language, the moral indifference born of unintelligence. Here, ChatGPT exhibits something like the banality of evil: plagiarism and apathy and obviation".