Sikander Hayat
@sikandhayat.bsky.social
Single-cell, spatial transcriptomics and AI computational method development. Finding data-driven drug targets for heart, kidney and fibrosis. Co-founder Sequantrix, academic group leader.
Reposted by Sikander Hayat
What happens to our immune system with aging, reducing vaccine response?
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
www.nature.com
October 29, 2025 at 4:10 PM
What happens to our immune system with aging, reducing vaccine response?
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Our human heart failure atlas with 1.8 million nuclei from 195 patients reveals novel cell states, integrates 52 GWAS traits and enables AI Agent driven target discovery. Collaboration between Uniklinik Aachen @rwth.bsky.social & @novonordisk.bsky.social. Poster at @americanheart.bsky.social Nov. 8.
Integrative single-cell and genetic profiling of human heart failure identifies targets for cardiomyocyte restoration https://www.medrxiv.org/content/10.1101/2025.10.09.25337646v1
October 18, 2025 at 5:16 AM
Our human heart failure atlas with 1.8 million nuclei from 195 patients reveals novel cell states, integrates 52 GWAS traits and enables AI Agent driven target discovery. Collaboration between Uniklinik Aachen @rwth.bsky.social & @novonordisk.bsky.social. Poster at @americanheart.bsky.social Nov. 8.
Reposted by Sikander Hayat
J.P. Flores, a core organizer for today's rallies and a bioinformatics researcher at the University of North Carolina, Chapel Hill, told Nature: “March 7 is the beginning — I don’t necessarily see it as the endpoint.” #StandUpForScience www.nature.com/articles/d41...
‘Scientists will not be silenced’: thousands protest Trump research cuts
Researchers at Stand Up for Science rallies voice defiance against the policies of US President Donald Trump’s administration.
www.nature.com
March 7, 2025 at 8:32 PM
J.P. Flores, a core organizer for today's rallies and a bioinformatics researcher at the University of North Carolina, Chapel Hill, told Nature: “March 7 is the beginning — I don’t necessarily see it as the endpoint.” #StandUpForScience www.nature.com/articles/d41...
Reposted by Sikander Hayat
Excited to share what I’ve been working on with @tkaraletsos.bsky.social to transform the field of drug discovery with atomistic foundation simulation models!
I could not be more thrilled to be working with this dream team.
achira.ai
I could not be more thrilled to be working with this dream team.
achira.ai
NEW: Achira has launched with a $33M seed round
I talked with CEO @jchodera.bsky.social about plans to combine AI- and physics-based methods for drug discovery and moving beyond 45 years of the same type of models behind molecular dynamics.
My latest @endpts.com:
endpts.com/achira-raise...
I talked with CEO @jchodera.bsky.social about plans to combine AI- and physics-based methods for drug discovery and moving beyond 45 years of the same type of models behind molecular dynamics.
My latest @endpts.com:
endpts.com/achira-raise...
February 21, 2025 at 2:15 PM
Excited to share what I’ve been working on with @tkaraletsos.bsky.social to transform the field of drug discovery with atomistic foundation simulation models!
I could not be more thrilled to be working with this dream team.
achira.ai
I could not be more thrilled to be working with this dream team.
achira.ai
Reposted by Sikander Hayat
The next generation of in situ multi-omics: www.nature.com/articles/s41...
The next generation of in situ multi-omics - Nature Methods
Spatial-Mux-seq adds to a growing portfolio of innovative spatial omics technologies and enables simultaneous profiling of up to five omic modalities in situ.
www.nature.com
January 27, 2025 at 9:33 PM
The next generation of in situ multi-omics: www.nature.com/articles/s41...
Our new decentralized single cell transcriptomics swarm learning approach for cell type annotation!
SwarmMAP: Swarm Learning for Decentralized Cell Type Annotation in Single Cell Sequencing Data https://www.biorxiv.org/content/10.1101/2025.01.13.632775v1
January 18, 2025 at 8:20 PM
Our new decentralized single cell transcriptomics swarm learning approach for cell type annotation!
Reposted by Sikander Hayat
Our (European Renal Association AKI Working Group) comment on the DEFENDER RCT: academic.oup.com/ndt/advance-...
SGLT2 inhibitors in critically ill patients are safe but do not reduce mortality or length of stay in the hospital. RCTs testing SGLT2i for AKI prevention and treatment are needed.
SGLT2 inhibitors in critically ill patients are safe but do not reduce mortality or length of stay in the hospital. RCTs testing SGLT2i for AKI prevention and treatment are needed.
DEFENDER Trial: Dapagliflozin for Critically Ill Patients with Acute Organ Dysfunction -Implications for clinicians
Jolanta Malyszko, the ERAKI Working group of the European Renal Association, Sophie De Seigneux, the ERAKI Working group of the European Renal Association,
academic.oup.com
January 18, 2025 at 7:12 PM
Our (European Renal Association AKI Working Group) comment on the DEFENDER RCT: academic.oup.com/ndt/advance-...
SGLT2 inhibitors in critically ill patients are safe but do not reduce mortality or length of stay in the hospital. RCTs testing SGLT2i for AKI prevention and treatment are needed.
SGLT2 inhibitors in critically ill patients are safe but do not reduce mortality or length of stay in the hospital. RCTs testing SGLT2i for AKI prevention and treatment are needed.
Thanks @erictopol.bsky.social for sharing our work!
Spatial omics of human arteries to understand what drives atherosclerosis: highlights role of the microvasculature (vasa vasorum), adventitial inflammation, migration of vascular smooth muscle cells (and more)
nature.com/articles/s44...
nature.com/articles/s44...
December 23, 2024 at 10:49 PM
Thanks @erictopol.bsky.social for sharing our work!
Reposted by Sikander Hayat
Our new paper put today @natureCVR led by @sikandhayat.bsky.social Tore Bleckwehl in collab with NovoNordisk 👇👇 www.nature.com/articles/s44...
Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis - Nature Cardiovascular Research
Bleckwehl et al. present a spatial transcriptomic map of atherosclerotic plaques across disease stages, revealing cellular recruitment and migration patterns and intercellular communication dynamics a...
www.nature.com
December 23, 2024 at 10:29 AM
Our new paper put today @natureCVR led by @sikandhayat.bsky.social Tore Bleckwehl in collab with NovoNordisk 👇👇 www.nature.com/articles/s44...
Reposted by Sikander Hayat
Our new paper: Label-free single cell RNA-sequencing leveraging genetix variability: www.nature.com/articles/s41... 🔥🔥
Label-free single-cell RNA multiplexing leveraging genetic variability - Nature Communications
Here the authors establish and benchmark a single cell RNA multiplexing framework that enables simple, yet robust high-throughput multiplexing leveraging single cell nucleotide polymorphisms of patien...
www.nature.com
December 5, 2024 at 1:32 PM
Our new paper: Label-free single cell RNA-sequencing leveraging genetix variability: www.nature.com/articles/s41... 🔥🔥
www.nature.com/articles/s41... Hello Single-cell world!
Label-free single-cell RNA multiplexing leveraging genetic variability - Nature Communications
Here the authors establish and benchmark a single cell RNA multiplexing framework that enables simple, yet robust high-throughput multiplexing leveraging single cell nucleotide polymorphisms of patien...
www.nature.com
December 5, 2024 at 6:53 PM
www.nature.com/articles/s41... Hello Single-cell world!