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Reposted by Silvia Vangelisti
Reposted by Silvia Vangelisti
Boyan Bonev
@boyanbonev.bsky.social
· Apr 4
Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis
The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell tra...
www.biorxiv.org
Reposted by Silvia Vangelisti
Boyan Bonev
@boyanbonev.bsky.social
· Mar 13
3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development
The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...
www.biorxiv.org