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sloanevolab.bsky.social
Dan Sloan
@sloanevolab.bsky.social
760 followers 440 following 65 posts
Molecular Evolutionary Biologist. Professor at Colorado State University Department of Biology. Personal account. Opinions my own (as if anyone else would want them). https://sites.google.com/site/danielbsloan
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danielbolnick.bsky.social
Daniel Bolnick @danielbolnick.bsky.social · 11d
The GRFP announcement from NSF cuts out an entire cohort of 2nd year students from consideration, without warning. This is so deeply unfair that it warrants a formal protest from the scientific community. If someone wants to work with me to craft an open letter and solicit signatures, LMK.
dangaristo.bsky.social
Dan Garisto @dangaristo.bsky.social · 11d
New: After a long wait, the GRFP solicitation is live! Deadlines have been extended to early November, so applicants have a bit over a month to submit. www.nsf.gov/funding/oppo...
NSF Graduate Research Fellowship Program (GRFP)
www.nsf.gov
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corybooker.com
Cory Booker @corybooker.com · 20d
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jbonfield.bsky.social
James Bonfield @jbonfield.bsky.social · 23d
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.

Ie: it's not us (Samtools team)! Be warned
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official-smbe.bsky.social
Society for Molecular Biology and Evolution @official-smbe.bsky.social · 28d
📢 The Call for Symposia for SMBE2026 is now open. We warmly invite you to submit a symposium proposal and help shape the scientific content of our annual meeting.

🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3

More information: smbe2026.org/symposia
SMBE2026 - Call for Symposia Proposals
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Reposted by Dan Sloan
jomcinerney.bsky.social
James McInerney @jomcinerney.bsky.social · 28d
I’ll be advertising a post-doc position (up to 3 year) soon. It will be for somebody that is a good programmer, interested in evolution & is keen to learn new machine learning & AI approaches. I don’t have a link to a job advertisement yet. The post will be hybrid working and based at U of Liverpool
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ecoevolab.bsky.social
Casey terHorst @ecoevolab.bsky.social · 29d
The GRFP lives!! (due end of October)
www.nsf.gov/funding/oppo...
NSF Graduate Research Fellowship Program (GRFP)
www.nsf.gov
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Reposted by Dan Sloan
nucleosomepolice.bsky.social
Karolin Luger @nucleosomepolice.bsky.social · 29d
❤️❤️❤️ CSU. Fort Collins is a lovely place to live, and students / faculty are awesome. I should know, I taught there for 15 years! Apply!
sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · 29d
The Department of Biology at Colorado State University is hiring an Assistant Professor in the area of plant-microbe interactions! Please spread the word!

jobs.colostate.edu/postings/165...
Assistant Professor Plant-Microbe Interactions
We seek a creative, collaborative, and visionary plant biologist to establish an internationally recognized research program at the forefront of plant-microbe interactions aimed at understanding how t...
jobs.colostate.edu
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sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · 29d
New preprint on the role of MutS2 genes in rescuing stalled/collided ribosomes in chloroplasts, led by Amanda Broz and many other contributors from the lab. Never expected to go down this road when we started working on plant MutS2 years ago. Feedback appreciated!

www.biorxiv.org/content/10.1...
Graphs showing plant responses to ribosome-stalling drugs as measured by photosynthetic efficient (Fv/Fm) and root length, with representative images of phenotypic mueasurements.
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sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · 29d
The Department of Biology at Colorado State University is hiring an Assistant Professor in the area of plant-microbe interactions! Please spread the word!

jobs.colostate.edu/postings/165...
Assistant Professor Plant-Microbe Interactions
We seek a creative, collaborative, and visionary plant biologist to establish an internationally recognized research program at the forefront of plant-microbe interactions aimed at understanding how t...
jobs.colostate.edu
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Reposted by Dan Sloan
3rdreviewer.bsky.social
Matthew Hahn @3rdreviewer.bsky.social · Sep 1
New paper led by @yadirapga.bsky.social!

Opossums have babies at 6-months of age, but are still highly male-biased in their mutations

academic.oup.com/genetics/adv...
Low mutation rate but high male-bias in the germline of a short-lived opossum
Abstract. Age and sex have been found to be important determinants of the mutation rate per generation in mammals, but the mechanisms underlying these fact
academic.oup.com
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Reposted by Dan Sloan
mollyprz.bsky.social
Molly Przeworski @mollyprz.bsky.social · Sep 2
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
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sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · Sep 2
On the same page there!
Slide showing definition of epistasis: Interactions between alleles at different loci. The phenotypic effect of an allele at one locus depends on which alleles are present at another locus in the genome.
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sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · Sep 2
Cuz I thought epistasis only exists when there is variation at both loci, which is why the QG folks talk about "converting" epistatic to additive variance when an allele is fixed at one locus. Dude, all I know is that my confidence is shot next time I teach the Genetics kiddos about epistasis. Ha.
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sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · Sep 1
Don't you also need Ab and ab to show that it's an interaction?
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sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · Sep 1
By that, you mean an alelle at each of two different loci? I don't think you can have epistasis until you consider that there is an alt allele (WT?) at each of those loci. I think of epistasis as being defined between loci, not between alleles, and it could not be done with only two haplotypes.
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sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · Sep 1
I guess one difference is that you can have a dominance relationship with just two alleles (e.g., one of your mutants and WT). But you couldn't have epistasis if there were just those two alleles.
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sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · Sep 1
But if you consider the sites of the mutations to be diff loci, you have one epistatic relationship between 2 bi-allelic loci to define. Both seem like reasonable framings, but I don't see how that makes dominance = epistasis? I might be misunderstanding tho.
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sloanevolab.bsky.social
Dan Sloan @sloanevolab.bsky.social · Sep 1
I think dominance is defined for pairs of alleles. In your two-mutant (A and a) example, you would also have a WT allele, so there are 3 dominance relationships (A vs a; A vs WT; a vs WT) to define.
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mitomaths.bsky.social
Iain Johnston @mitomaths.bsky.social · Jun 17
There'll be 2 PhD positions (math / microscopy) on MitoPhyto. But the Norwegian research council is also offering opportunities for non-European postdocs to come to Norway for 3 years associated with FRIPRO projects. Please DM me if interested!
www.forskningsradet.no/en/call-for-...
Recruitment of Talented Researchers to Norway
The Research Council supports the recruitment of talented international researchers to the Research Council's centre calls and for projects funded ...
www.forskningsradet.no
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Reposted by Dan Sloan
maddyseale.bsky.social
Maddy Seale @maddyseale.bsky.social · Aug 22
My pick for In Other Journals this week:
MSH1 suppresses organelle mutation - an investigation of how many plants maintain very low mitochondrial mutation rates

My summary here:
www.science.org/doi/10.1126/...

Paper here: doi.org/10.1371/jour...
@sloanevolab.bsky.social
#PlantScience
In Other Journals
Editors’ selections from the current scientific literature
www.science.org
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iochromaland.bsky.social
Stacey D. Smith @iochromaland.bsky.social · Aug 11
Big news! We are recruiting a postdoc to work on tomatillo evolution: jobs.colorado.edu/jobs/JobDeta.... The clade containing tomatillos and its allies (ca 300 spp) has evolved lantern fruits at least 25 times - we want to know why! Join us @rociodeanna.bsky.social & @caschenck-bio.bsky.social
Postdoctoral Fellow in Tomatillo Evolution
jobs.colorado.edu
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annttate.bsky.social
Ann T. Tate @annttate.bsky.social · Aug 15
Pls RT: We are recruiting a postdoc (and potentially an RA or staff scientist) to work on the evolution of stage-structured immune systems! Experimental evolution, natural variation in immunity, and/or evo genomics in flour beetles (Tribolium). See ad here: my.vanderbilt.edu/tatelab/join...
Scale highlighting trade-offs between larval and adult beetles in response to infection A teaser of panels illustrating potential approaches to studying stage-structured immune systems, including transcriptomics, experimental evolution, and experiments in wild-derived populations
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Reposted by Dan Sloan
psudmant.bsky.social
Peter Sudmant @psudmant.bsky.social · Aug 13
The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052
Postdoctoral Scholar – Genomics, Aging, Somatic Mutation, Structural Variation, Evolution , Cancer – Integrative Biology
University of California, Berkeley is hiring. Apply now!
aprecruit.berkeley.edu
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mollyschumer.bsky.social
Molly Schumer @mollyschumer.bsky.social · Aug 10
Our review on the last decade+ of hybrid incompatibility research is now out! www.sciencedirect.com/science/arti...

Original thread here: bsky.app/profile/moll...
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Reposted by Dan Sloan
teralevin.bsky.social
Tera Levin @teralevin.bsky.social · Aug 5
I'm excited to announce our new biorxiv preprint, wherein we investigate the evolution of the weirdest genetic locus I've ever seen! Behold the tgr genes of the social amoeba, which mediate self/non-self discrimination during facultative multicellularity 🐅 🧵 1/
www.biorxiv.org/content/10.1...
Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes in Dictyostelium
Cells require highly polymorphic receptors to perform accurate self/non-self recognition. In the amoeba Dicytostelium discoideum, polymorphic TgrB1 & TgrC1 proteins are used to bind sister cells and e...
www.biorxiv.org
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