Spirochrome
@spirochrome.com
Our main focus is to offer innovative tools for live cell fluorescence imaging to the scientific community.
https://spirochrome.com/
https://spirochrome.com/
You are correct! mtDNA staining is typically performed with an intercalating DNA dye with nanomolar affinity for dsDNA. SPY-DNA probes, primarily designed for live cell imaging, are DNA groove binders and have a lower affinity to avoid toxicity. Probably not strong enough for robust mtDNA staining.
January 9, 2026 at 8:47 AM
You are correct! mtDNA staining is typically performed with an intercalating DNA dye with nanomolar affinity for dsDNA. SPY-DNA probes, primarily designed for live cell imaging, are DNA groove binders and have a lower affinity to avoid toxicity. Probably not strong enough for robust mtDNA staining.
The images were acquired on a @leicamicrosystems.bsky.social Stellaris system by
@bioarm.bsky.social from @centriolelab.bsky.social.
Huge thank you for trying this out!
@bioarm.bsky.social from @centriolelab.bsky.social.
Huge thank you for trying this out!
January 8, 2026 at 2:25 PM
The images were acquired on a @leicamicrosystems.bsky.social Stellaris system by
@bioarm.bsky.social from @centriolelab.bsky.social.
Huge thank you for trying this out!
@bioarm.bsky.social from @centriolelab.bsky.social.
Huge thank you for trying this out!
The images in the main text are also definitely worth a look!
November 24, 2025 at 1:34 PM
The images in the main text are also definitely worth a look!
More information about Flipper-TR on our website spirochrome.com/product/flip...
Flipper-TR® - Live cell membrane tension probe - spirochrome
Flipper-TR® is a live cell membrane tension probe
spirochrome.com
November 4, 2025 at 9:19 AM
More information about Flipper-TR on our website spirochrome.com/product/flip...
Reposted by Spirochrome
October 29, 2025 at 9:30 AM
And thanks to @joachimgoedhart.bsky.social for the Bouncy-Curtain imageJ plugin.
github.com/JoachimGoedh...
github.com/JoachimGoedh...
GitHub - JoachimGoedhart/Bouncy-Curtain: ImageJ/FIJI macro to generate an animated, curtain-style comparison of two images
ImageJ/FIJI macro to generate an animated, curtain-style comparison of two images - JoachimGoedhart/Bouncy-Curtain
github.com
October 29, 2025 at 9:44 AM
And thanks to @joachimgoedhart.bsky.social for the Bouncy-Curtain imageJ plugin.
github.com/JoachimGoedh...
github.com/JoachimGoedh...
October 29, 2025 at 9:30 AM