STEMCELL Science News
@stemcellsciencenews.com
A complete resource for the latest discoveries in cell biology, from organoids to immunology. Brought to you by STEMCELL Technologies.
❄️ Happy Holidays!
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
December 22, 2025 at 9:13 PM
❄️ Happy Holidays!
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
Check out this new study from Dr. Tanya Stoyanova's lab! 🥼
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
December 19, 2025 at 4:47 PM
Check out this new study from Dr. Tanya Stoyanova's lab! 🥼
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
Dr. Masoud Manjili and collaborators identify Bcl-xL as a central survival factor in chemotherapy-induced dormancy.
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
December 19, 2025 at 12:09 AM
Dr. Masoud Manjili and collaborators identify Bcl-xL as a central survival factor in chemotherapy-induced dormancy.
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
#Integrin α3 is implicated in #ADHD and other neurodevelopmental disorders.
A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes.
https://go.nature.com/4aiBN2P
A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes.
https://go.nature.com/4aiBN2P
December 17, 2025 at 11:06 PM
#Integrin α3 is implicated in #ADHD and other neurodevelopmental disorders.
A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes.
https://go.nature.com/4aiBN2P
A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes.
https://go.nature.com/4aiBN2P
A group of scientists from Sun Yat-sen University show that as #BladderCancer progresses, matrix stiffness and tumor #stemness increase.
High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size.
💡 https://go.nature.com/4pEqerl
High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size.
💡 https://go.nature.com/4pEqerl
December 17, 2025 at 7:34 PM
A group of scientists from Sun Yat-sen University show that as #BladderCancer progresses, matrix stiffness and tumor #stemness increase.
High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size.
💡 https://go.nature.com/4pEqerl
High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size.
💡 https://go.nature.com/4pEqerl
Led by Drs. Jocelynn Pearl and Annette Marleau, scientists review clinical advancements in the understanding of the therapeutic properties of MSCs and their subpopulations, assessing the evidence supporting their use in #RegenerativeMedicine.
💡Read it here! bit.ly/48N2kmg
💡Read it here! bit.ly/48N2kmg
December 16, 2025 at 11:59 PM
Led by Drs. Jocelynn Pearl and Annette Marleau, scientists review clinical advancements in the understanding of the therapeutic properties of MSCs and their subpopulations, assessing the evidence supporting their use in #RegenerativeMedicine.
💡Read it here! bit.ly/48N2kmg
💡Read it here! bit.ly/48N2kmg
🧪 Dr. Justus Duyster and team found that the STAT5-activating oncogenes JAK2 p.V617F, FLT3-ITD, and BCR::ABL1 induce oncostatin M, which triggers disease progression and immunosuppression.
@sigtrans-sttt.bsky.social | https://go.nature.com/4q938t4
@sigtrans-sttt.bsky.social | https://go.nature.com/4q938t4
December 16, 2025 at 8:34 PM
🧪 Dr. Justus Duyster and team found that the STAT5-activating oncogenes JAK2 p.V617F, FLT3-ITD, and BCR::ABL1 induce oncostatin M, which triggers disease progression and immunosuppression.
@sigtrans-sttt.bsky.social | https://go.nature.com/4q938t4
@sigtrans-sttt.bsky.social | https://go.nature.com/4q938t4
Hot off the press in @natcomms.nature.com 🔥
Drs. Mads Hald Andersen and Inge Marie Svane report long-term outcomes from the MM1636 trial, which evaluates a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with melanoma. 💊
https://go.nature.com/48SQ0RE
Drs. Mads Hald Andersen and Inge Marie Svane report long-term outcomes from the MM1636 trial, which evaluates a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with melanoma. 💊
https://go.nature.com/48SQ0RE
December 16, 2025 at 12:12 AM
Hot off the press in @natcomms.nature.com 🔥
Drs. Mads Hald Andersen and Inge Marie Svane report long-term outcomes from the MM1636 trial, which evaluates a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with melanoma. 💊
https://go.nature.com/48SQ0RE
Drs. Mads Hald Andersen and Inge Marie Svane report long-term outcomes from the MM1636 trial, which evaluates a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with melanoma. 💊
https://go.nature.com/48SQ0RE
From the Abrams & Brentjens labs, scientists reported that IL-36γ armored CAR T cells eradicate primary solid tumors and enable rejection of rechallenged antigen-negative tumors.
📙 Learn more: https://bit.ly/4qf3o9S
📙 Learn more: https://bit.ly/4qf3o9S
December 15, 2025 at 11:06 PM
From the Abrams & Brentjens labs, scientists reported that IL-36γ armored CAR T cells eradicate primary solid tumors and enable rejection of rechallenged antigen-negative tumors.
📙 Learn more: https://bit.ly/4qf3o9S
📙 Learn more: https://bit.ly/4qf3o9S
This @pnas.org study found that prostaglandin E2(PGE2) produced in TME confers the tumor-infiltrating Tregs signature to #Tregs via its receptors, EP2 and EP4.
➡️ Read the full article here: bit.ly/4q2xahV
➡️ Read the full article here: bit.ly/4q2xahV
December 12, 2025 at 4:52 PM
This @pnas.org study found that prostaglandin E2(PGE2) produced in TME confers the tumor-infiltrating Tregs signature to #Tregs via its receptors, EP2 and EP4.
➡️ Read the full article here: bit.ly/4q2xahV
➡️ Read the full article here: bit.ly/4q2xahV
Drs. Michael Keller and Navid Djassemi examine advancements in virus-specific T cell manufacturing that broaden their accessibility to a wider range of viral infections and immunocompromised populations.
👉 Read their review in @bloodjournals.hematology.org bit.ly/4oJ1Qnd
👉 Read their review in @bloodjournals.hematology.org bit.ly/4oJ1Qnd
December 11, 2025 at 12:53 AM
Drs. Michael Keller and Navid Djassemi examine advancements in virus-specific T cell manufacturing that broaden their accessibility to a wider range of viral infections and immunocompromised populations.
👉 Read their review in @bloodjournals.hematology.org bit.ly/4oJ1Qnd
👉 Read their review in @bloodjournals.hematology.org bit.ly/4oJ1Qnd
In this study, scientists utilized androgenetic, parthenogenetic, and biparental hESCs and their neural derivatives to identify novel imprinted genes by analyzing their methylome and transcriptome profiles.
📖 Read more: https://bit.ly/452mvvr
📖 Read more: https://bit.ly/452mvvr
December 10, 2025 at 8:47 PM
In this study, scientists utilized androgenetic, parthenogenetic, and biparental hESCs and their neural derivatives to identify novel imprinted genes by analyzing their methylome and transcriptome profiles.
📖 Read more: https://bit.ly/452mvvr
📖 Read more: https://bit.ly/452mvvr
🧠 This study suggests that targeting the CCL2/CCR2/ERK1/2 pathway may help overcome chemoresistance in #glioblastomas caused by cancer-associated fibroblasts!
👉 https://go.nature.com/3XI0cHu
👉 https://go.nature.com/3XI0cHu
December 10, 2025 at 6:10 PM
🧠 This study suggests that targeting the CCL2/CCR2/ERK1/2 pathway may help overcome chemoresistance in #glioblastomas caused by cancer-associated fibroblasts!
👉 https://go.nature.com/3XI0cHu
👉 https://go.nature.com/3XI0cHu
🔬 Researchers investigated the involvement of cyclin B2 in pancreatic ductal adenocarcinoma growth and progression using glycolysis inhibitors in vivo and in vitro.
🔗 https://bit.ly/44gwTzD
🔗 https://bit.ly/44gwTzD
December 9, 2025 at 5:49 PM
🔬 Researchers investigated the involvement of cyclin B2 in pancreatic ductal adenocarcinoma growth and progression using glycolysis inhibitors in vivo and in vitro.
🔗 https://bit.ly/44gwTzD
🔗 https://bit.ly/44gwTzD
💓 Scientists with Dr. Nobuaki Fukuma at @columbiauniversity.bsky.social investigated whether and how #cardiomyocyte NO-sensitive soluble guanylyl cyclase mediates female-specific, adaptive right ventricular pressure-overload remodeling.
👉 https://bit.ly/3WYQdx2
👉 https://bit.ly/3WYQdx2
December 9, 2025 at 12:11 AM
💓 Scientists with Dr. Nobuaki Fukuma at @columbiauniversity.bsky.social investigated whether and how #cardiomyocyte NO-sensitive soluble guanylyl cyclase mediates female-specific, adaptive right ventricular pressure-overload remodeling.
👉 https://bit.ly/3WYQdx2
👉 https://bit.ly/3WYQdx2
Researchers found that isoflurane facilitates hemispheric lateralization in BBB permeability, leading to different responses between the left and right hemispheres. 🧠
📖 https://bit.ly/3Yho4lq
📖 https://bit.ly/3Yho4lq
December 8, 2025 at 11:55 PM
Researchers found that isoflurane facilitates hemispheric lateralization in BBB permeability, leading to different responses between the left and right hemispheres. 🧠
📖 https://bit.ly/3Yho4lq
📖 https://bit.ly/3Yho4lq
📊 In this study, an integrative analysis of public datasets and immunohistochemistry revealed that ACTC1 is upregulated in prostate cancer, identifying ACTC1 as an oncogenic regulator of prostate cancer progression.
🔗 https://bit.ly/4osaoPm
🔗 https://bit.ly/4osaoPm
December 5, 2025 at 5:14 PM
📊 In this study, an integrative analysis of public datasets and immunohistochemistry revealed that ACTC1 is upregulated in prostate cancer, identifying ACTC1 as an oncogenic regulator of prostate cancer progression.
🔗 https://bit.ly/4osaoPm
🔗 https://bit.ly/4osaoPm
🥊 Researchers with Giovanni Papa and Jiazhuo He perform in vivo CRISPR knockout screening for gastric tumor suppressors using gastric murine organoids in a subcutaneous as well as a surgical model of orthotopic tumor growth.
🔗 https://bit.ly/3Ks8AI7
🔗 https://bit.ly/3Ks8AI7
December 4, 2025 at 4:45 PM
🥊 Researchers with Giovanni Papa and Jiazhuo He perform in vivo CRISPR knockout screening for gastric tumor suppressors using gastric murine organoids in a subcutaneous as well as a surgical model of orthotopic tumor growth.
🔗 https://bit.ly/3Ks8AI7
🔗 https://bit.ly/3Ks8AI7
Drs. Wolfdieter Springer, Xu Hou, and @mayoclinic.org co-authors revealed complex interactions between #LewyBody pathology, neurofibrillary tangle pathology, and genetic mitophagy modifiers in Lewy body #Dementia brains. 🧠
📝 Check out the paper: https://bit.ly/3MfHUuU
📝 Check out the paper: https://bit.ly/3MfHUuU
December 3, 2025 at 11:07 PM
Drs. Wolfdieter Springer, Xu Hou, and @mayoclinic.org co-authors revealed complex interactions between #LewyBody pathology, neurofibrillary tangle pathology, and genetic mitophagy modifiers in Lewy body #Dementia brains. 🧠
📝 Check out the paper: https://bit.ly/3MfHUuU
📝 Check out the paper: https://bit.ly/3MfHUuU
🩸 Acute #leukemia is the most common type of cancer in children; however, the etiology is poorly understood.
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
December 3, 2025 at 6:13 PM
🩸 Acute #leukemia is the most common type of cancer in children; however, the etiology is poorly understood.
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
Among the five types of stem cells that have been experimentally applied to #LiverDisease, #MSCs have emerged as the most extensively studied, with the largest number of experimental and clinical research platforms worldwide.
📖 Read the review: https://bit.ly/48tNMYN
📖 Read the review: https://bit.ly/48tNMYN
December 2, 2025 at 10:14 PM
Among the five types of stem cells that have been experimentally applied to #LiverDisease, #MSCs have emerged as the most extensively studied, with the largest number of experimental and clinical research platforms worldwide.
📖 Read the review: https://bit.ly/48tNMYN
📖 Read the review: https://bit.ly/48tNMYN
💊 Researchers uncover a heme rheostat that is connected to gene expression and drug sensitivity in #AML and implicates heme biosynthesis enzyme inhibition as a trigger of cuproptosis.
🔗 https://bit.ly/4p6Wsvf
🔗 https://bit.ly/4p6Wsvf
December 2, 2025 at 5:07 PM
💊 Researchers uncover a heme rheostat that is connected to gene expression and drug sensitivity in #AML and implicates heme biosynthesis enzyme inhibition as a trigger of cuproptosis.
🔗 https://bit.ly/4p6Wsvf
🔗 https://bit.ly/4p6Wsvf
🧫 By leveraging lipid nanoparticles designed to selectively transfect tumor-associated #macrophages, scientists circumvent extensive ex vivo manipulation and achieve robust CAR expression directly within the tumor microenvironment.
👉 https://bit.ly/3KqyagG
👉 https://bit.ly/3KqyagG
December 2, 2025 at 12:55 AM
🧫 By leveraging lipid nanoparticles designed to selectively transfect tumor-associated #macrophages, scientists circumvent extensive ex vivo manipulation and achieve robust CAR expression directly within the tumor microenvironment.
👉 https://bit.ly/3KqyagG
👉 https://bit.ly/3KqyagG
A team of scientists from Air Force Medical University clarify how N-trans-feruloyloctopamine, as an FGF2 inhibitor, mitigates UVB-induced #SkinDamage and #hyperpigmentation by regulating this pathway.
💡Check it out: bit.ly/3KB67Lx
💡Check it out: bit.ly/3KB67Lx
December 2, 2025 at 12:20 AM
A team of scientists from Air Force Medical University clarify how N-trans-feruloyloctopamine, as an FGF2 inhibitor, mitigates UVB-induced #SkinDamage and #hyperpigmentation by regulating this pathway.
💡Check it out: bit.ly/3KB67Lx
💡Check it out: bit.ly/3KB67Lx
Liver cancer patients may soon be able to check if their disease has returned with a simple blood test that detects tumor-specific DNA changes in the bloodstream, as part of a new Curtain University-led research project.
📰 Check out the article: bit.ly/4ootZzU
📰 Check out the article: bit.ly/4ootZzU
November 29, 2025 at 2:02 AM
Liver cancer patients may soon be able to check if their disease has returned with a simple blood test that detects tumor-specific DNA changes in the bloodstream, as part of a new Curtain University-led research project.
📰 Check out the article: bit.ly/4ootZzU
📰 Check out the article: bit.ly/4ootZzU