STEMCELL Science News
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A complete resource for the latest discoveries in cell biology, from organoids to immunology. Brought to you by STEMCELL Technologies.
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Science News by @stemcell.com offers 20 regular newsletters with the latest peer-reviewed research, reviews, and industry news delivered straight to your inbox.
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Science News by @stemcell.com offers 20 regular newsletters with the latest peer-reviewed research, reviews, and industry news delivered straight to your inbox.
💌 Subscribe here: https://bit.ly/47lRBjq
Scientists investigated the central role of histone deacetylase 6 in #SCLC progression and its regulatory mechanisms to identify novel therapeutic strategies.
📚 Read the article to learn more: https://bit.ly/4qQlM9i
📚 Read the article to learn more: https://bit.ly/4qQlM9i
January 15, 2026 at 6:36 PM
Scientists investigated the central role of histone deacetylase 6 in #SCLC progression and its regulatory mechanisms to identify novel therapeutic strategies.
📚 Read the article to learn more: https://bit.ly/4qQlM9i
📚 Read the article to learn more: https://bit.ly/4qQlM9i
🧪 Researchers create an efficient combined anti-tumor lipid nanoparticle (LNP) delivery system.
They added DMG-PEG2000-FA to the four-component LNP system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.
👉 https://bit.ly/3Lrwi7W
They added DMG-PEG2000-FA to the four-component LNP system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.
👉 https://bit.ly/3Lrwi7W
January 15, 2026 at 5:05 PM
🧪 Researchers create an efficient combined anti-tumor lipid nanoparticle (LNP) delivery system.
They added DMG-PEG2000-FA to the four-component LNP system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.
👉 https://bit.ly/3Lrwi7W
They added DMG-PEG2000-FA to the four-component LNP system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.
👉 https://bit.ly/3Lrwi7W
Researchers define a pathogenic monocyte transcriptional state linking systemic immune dysfunction to persistent long #COVID disease.
#OpenAccess
🔓 Learn more: https://go.nature.com/49xKvbj
#OpenAccess
🔓 Learn more: https://go.nature.com/49xKvbj
January 14, 2026 at 11:53 PM
Researchers define a pathogenic monocyte transcriptional state linking systemic immune dysfunction to persistent long #COVID disease.
#OpenAccess
🔓 Learn more: https://go.nature.com/49xKvbj
#OpenAccess
🔓 Learn more: https://go.nature.com/49xKvbj
In a recent @cp-cellrepmethods.bsky.social study, scientists generated hPSC-derived T cell progenitors capable of long-term T #lymphopoiesis in vivo without forced expression of defined transcription factors.
💡 https://bit.ly/3LcZnnD
💡 https://bit.ly/3LcZnnD
January 14, 2026 at 5:43 PM
In a recent @cp-cellrepmethods.bsky.social study, scientists generated hPSC-derived T cell progenitors capable of long-term T #lymphopoiesis in vivo without forced expression of defined transcription factors.
💡 https://bit.ly/3LcZnnD
💡 https://bit.ly/3LcZnnD
Reposted by STEMCELL Science News
How can a common virus contribute to a rare disease?
A new @cp-immunity.bsky.social study from @biomedizin.unibas.ch links EBV to early MS-like lesion formation by showing how B cells can act at the very start of the disease process.
🔗 doi.org/10.1016/j.ce...
@unibas.ch #EBV #MultipleSclerosis
A new @cp-immunity.bsky.social study from @biomedizin.unibas.ch links EBV to early MS-like lesion formation by showing how B cells can act at the very start of the disease process.
🔗 doi.org/10.1016/j.ce...
@unibas.ch #EBV #MultipleSclerosis
January 14, 2026 at 7:33 AM
How can a common virus contribute to a rare disease?
A new @cp-immunity.bsky.social study from @biomedizin.unibas.ch links EBV to early MS-like lesion formation by showing how B cells can act at the very start of the disease process.
🔗 doi.org/10.1016/j.ce...
@unibas.ch #EBV #MultipleSclerosis
A new @cp-immunity.bsky.social study from @biomedizin.unibas.ch links EBV to early MS-like lesion formation by showing how B cells can act at the very start of the disease process.
🔗 doi.org/10.1016/j.ce...
@unibas.ch #EBV #MultipleSclerosis
Dr. Melanie Rutkowski (@rutkowskilab.bsky.social) has been selected as a Victoria’s Secret Rising Innovator, receiving a grant to further her studies of the role of the microbiome in #OvarianCancer and in the disease’s ability to resist immune therapy.
Congratulations! 🤩
🗞️ https://bit.ly/45d2frb
Congratulations! 🤩
🗞️ https://bit.ly/45d2frb
January 13, 2026 at 9:46 PM
Dr. Melanie Rutkowski (@rutkowskilab.bsky.social) has been selected as a Victoria’s Secret Rising Innovator, receiving a grant to further her studies of the role of the microbiome in #OvarianCancer and in the disease’s ability to resist immune therapy.
Congratulations! 🤩
🗞️ https://bit.ly/45d2frb
Congratulations! 🤩
🗞️ https://bit.ly/45d2frb
🚨 This study presents the development and validation of a noninvasive circulating cell-free DNA–based model for early pancreatic cancer detection.
👉 https://bit.ly/457t2Fk
👉 https://bit.ly/457t2Fk
January 13, 2026 at 5:48 PM
🚨 This study presents the development and validation of a noninvasive circulating cell-free DNA–based model for early pancreatic cancer detection.
👉 https://bit.ly/457t2Fk
👉 https://bit.ly/457t2Fk
Piezo1 exacerbates microvascular and skeletal muscle damage in acute limb ischemia–reperfusion injury by facilitating the cPLA2-dependent release of arachidonic acid and promoting ACSL4-driven lipid peroxidation.
👉 https://go.nature.com/3NGmZl6
👉 https://go.nature.com/3NGmZl6
January 13, 2026 at 12:32 AM
Piezo1 exacerbates microvascular and skeletal muscle damage in acute limb ischemia–reperfusion injury by facilitating the cPLA2-dependent release of arachidonic acid and promoting ACSL4-driven lipid peroxidation.
👉 https://go.nature.com/3NGmZl6
👉 https://go.nature.com/3NGmZl6
💪 Investigators at @newcastleuni.bsky.social utilized datasets from single-nuclei RNA sequencing of Duchenne muscular dystrophy muscle samples to examine the dysregulation of molecular pathways in comparison to healthy control muscle.
🔗 https://go.nature.com/4sCKKul
🔗 https://go.nature.com/4sCKKul
January 13, 2026 at 12:28 AM
💪 Investigators at @newcastleuni.bsky.social utilized datasets from single-nuclei RNA sequencing of Duchenne muscular dystrophy muscle samples to examine the dysregulation of molecular pathways in comparison to healthy control muscle.
🔗 https://go.nature.com/4sCKKul
🔗 https://go.nature.com/4sCKKul
In this study with a target trial emulation design, sodium-glucose cotransporter 2 inhibitor use was associated with delayed hormone therapy failure in patients with #ProstateCancer, suggesting a potential oncologic benefit beyond glucose lowering.
🆕 https://bit.ly/4baQ56b
🆕 https://bit.ly/4baQ56b
January 10, 2026 at 12:41 AM
In this study with a target trial emulation design, sodium-glucose cotransporter 2 inhibitor use was associated with delayed hormone therapy failure in patients with #ProstateCancer, suggesting a potential oncologic benefit beyond glucose lowering.
🆕 https://bit.ly/4baQ56b
🆕 https://bit.ly/4baQ56b
A research group from Soochow University found that chromobox 4 upregulation promotes #GastricCancer progression via β-catenin signaling activation.
💡 Learn more: https://bit.ly/4jCFfIi
💡 Learn more: https://bit.ly/4jCFfIi
January 9, 2026 at 9:43 PM
A research group from Soochow University found that chromobox 4 upregulation promotes #GastricCancer progression via β-catenin signaling activation.
💡 Learn more: https://bit.ly/4jCFfIi
💡 Learn more: https://bit.ly/4jCFfIi
Drs. Sarah Herzog, Suzanne Fuqua, and their @bcmhouston.bsky.social colleagues identify replication stress and DNA damage responses as key dysregulated pathways in ESR1 mutant #BreastCancer.
🆕 Check it out: https://bit.ly/49epKTk
🆕 Check it out: https://bit.ly/49epKTk
January 8, 2026 at 11:45 PM
Drs. Sarah Herzog, Suzanne Fuqua, and their @bcmhouston.bsky.social colleagues identify replication stress and DNA damage responses as key dysregulated pathways in ESR1 mutant #BreastCancer.
🆕 Check it out: https://bit.ly/49epKTk
🆕 Check it out: https://bit.ly/49epKTk
🧫 This review comprehensively examines integrative bioengineering strategies for endometrial regeneration, focusing on the synergistic applications of biomaterials, stem cells, #organoids, and organ-on-a-chip technologies.
📖 https://bit.ly/3LlxtWq
📖 https://bit.ly/3LlxtWq
January 8, 2026 at 4:46 PM
🧫 This review comprehensively examines integrative bioengineering strategies for endometrial regeneration, focusing on the synergistic applications of biomaterials, stem cells, #organoids, and organ-on-a-chip technologies.
📖 https://bit.ly/3LlxtWq
📖 https://bit.ly/3LlxtWq
🧠 Scientists find that #glioblastoma stem cells displayed relative resistance to cuproptosis with circadian variation of intracellular copper levels.
👇 Check it out!
@jci.org | https://bit.ly/3YlTzuV
👇 Check it out!
@jci.org | https://bit.ly/3YlTzuV
January 7, 2026 at 4:53 PM
🧠 Scientists find that #glioblastoma stem cells displayed relative resistance to cuproptosis with circadian variation of intracellular copper levels.
👇 Check it out!
@jci.org | https://bit.ly/3YlTzuV
👇 Check it out!
@jci.org | https://bit.ly/3YlTzuV
🔬 Researchers evaluated the immunomodulatory function of PD-L1-(+) MSCs using scRNA-seq and investigated their roles in suppressing inflammation and regulating pathological bone formation in curdlan-induced SKG ankylosing spondylitis mouse models.
🔗 https://bit.ly/4qwlOTE
🔗 https://bit.ly/4qwlOTE
January 6, 2026 at 6:15 PM
🔬 Researchers evaluated the immunomodulatory function of PD-L1-(+) MSCs using scRNA-seq and investigated their roles in suppressing inflammation and regulating pathological bone formation in curdlan-induced SKG ankylosing spondylitis mouse models.
🔗 https://bit.ly/4qwlOTE
🔗 https://bit.ly/4qwlOTE
Scientists including Dr. Shaza Aly assess the #WoundHealing efficacy of fractions derived from Rosmarinus officinalis through phytochemical profiling, antioxidant assays, and in vitro scratch wound models. 🌿
🔎 Take a closer look: https://go.nature.com/495h6X6
🔎 Take a closer look: https://go.nature.com/495h6X6
January 6, 2026 at 1:44 AM
Scientists including Dr. Shaza Aly assess the #WoundHealing efficacy of fractions derived from Rosmarinus officinalis through phytochemical profiling, antioxidant assays, and in vitro scratch wound models. 🌿
🔎 Take a closer look: https://go.nature.com/495h6X6
🔎 Take a closer look: https://go.nature.com/495h6X6
The Dushek lab demonstrated that super selective T cells with reduced cross-reactivity and enhanced ligand discrimination can be generated without impacting on-target potency and importantly, without modifying the TCR.
🔗 https://go.nature.com/4jALBYE
🔗 https://go.nature.com/4jALBYE
January 6, 2026 at 1:27 AM
The Dushek lab demonstrated that super selective T cells with reduced cross-reactivity and enhanced ligand discrimination can be generated without impacting on-target potency and importantly, without modifying the TCR.
🔗 https://go.nature.com/4jALBYE
🔗 https://go.nature.com/4jALBYE
Reposted by STEMCELL Science News
Happy Holidays from the CISR! May all your days and fluorophores be BRIGHT. #MicroscopyMonday
December 22, 2025 at 10:24 PM
Happy Holidays from the CISR! May all your days and fluorophores be BRIGHT. #MicroscopyMonday
Reposted by STEMCELL Science News
Happy Holidays from our team!
December 23, 2025 at 1:13 PM
Happy Holidays from our team!
❄️ Happy Holidays!
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
December 22, 2025 at 9:13 PM
❄️ Happy Holidays!
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
Check out this new study from Dr. Tanya Stoyanova's lab! 🥼
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
December 19, 2025 at 4:47 PM
Check out this new study from Dr. Tanya Stoyanova's lab! 🥼
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
Reposted by STEMCELL Science News
Some fiery prefrontal cortical neurons projecting to the locus coeruleus that are labeled in the mouse brain
#FluorescenceFriday 🧠🔬🔥
Image credit to @rehg-j.bsky.social and the @lieberinstitute.bsky.social Circuits Team
#FluorescenceFriday 🧠🔬🔥
Image credit to @rehg-j.bsky.social and the @lieberinstitute.bsky.social Circuits Team
December 19, 2025 at 2:28 PM
Some fiery prefrontal cortical neurons projecting to the locus coeruleus that are labeled in the mouse brain
#FluorescenceFriday 🧠🔬🔥
Image credit to @rehg-j.bsky.social and the @lieberinstitute.bsky.social Circuits Team
#FluorescenceFriday 🧠🔬🔥
Image credit to @rehg-j.bsky.social and the @lieberinstitute.bsky.social Circuits Team
Dr. Masoud Manjili and collaborators identify Bcl-xL as a central survival factor in chemotherapy-induced dormancy.
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
December 19, 2025 at 12:09 AM
Dr. Masoud Manjili and collaborators identify Bcl-xL as a central survival factor in chemotherapy-induced dormancy.
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
Love the #bacteriophage cheese board! 😂
Nature asked readers about their favorite scientific gifts. Here’s what they said.
What is your favorite scientific gift? 🧪
What is your favorite scientific gift? 🧪
The gift that shaped my career in science
Nature asked about your most memorable scientific gifts. You delivered.
go.nature.com
December 18, 2025 at 5:49 PM
Love the #bacteriophage cheese board! 😂
Reposted by STEMCELL Science News
Very pleased to share our new review "The Evolving Landscape of Brain Metastasis" in @cp-trendscancer.bsky.social 🧠🔬🧪
Grateful to an outstanding team of co-authors, all pioneers in the #brain #metastasis field and to @valientelab.bsky.social for co-leading this 🙏🏻
Link: www.cell.com/trends/cance...
Grateful to an outstanding team of co-authors, all pioneers in the #brain #metastasis field and to @valientelab.bsky.social for co-leading this 🙏🏻
Link: www.cell.com/trends/cance...
December 17, 2025 at 4:49 PM
Very pleased to share our new review "The Evolving Landscape of Brain Metastasis" in @cp-trendscancer.bsky.social 🧠🔬🧪
Grateful to an outstanding team of co-authors, all pioneers in the #brain #metastasis field and to @valientelab.bsky.social for co-leading this 🙏🏻
Link: www.cell.com/trends/cance...
Grateful to an outstanding team of co-authors, all pioneers in the #brain #metastasis field and to @valientelab.bsky.social for co-leading this 🙏🏻
Link: www.cell.com/trends/cance...