Stephan Hacker
@stephanhacker2.bsky.social
Assistant Professor at Leiden University. Covalent inhibitors and chemoproteomics for antibiotics. Views my own. he/him/his. https://orcid.org/0000-0001-5420-4824
Great speech by the new president of @unileiden.bsky.social, Luc Sels, at the New Year's reception of @leidenscience.bsky.social. He gave great insights into his vision for the future of our university including excellent fundamental science, collaboration, internationalization and societal impact.
January 6, 2026 at 3:35 PM
Great speech by the new president of @unileiden.bsky.social, Luc Sels, at the New Year's reception of @leidenscience.bsky.social. He gave great insights into his vision for the future of our university including excellent fundamental science, collaboration, internationalization and societal impact.
Very interesting Tuesday Talk by Meindert Lamers at the New Year's reception of @leidenscience.bsky.social. He talked about the power of different electron microscopy techniques to visualize biological samples on length scales from tissues to individual molecules. www.nature.com/articles/s44...
January 6, 2026 at 3:14 PM
Very interesting Tuesday Talk by Meindert Lamers at the New Year's reception of @leidenscience.bsky.social. He talked about the power of different electron microscopy techniques to visualize biological samples on length scales from tissues to individual molecules. www.nature.com/articles/s44...
Our dean Jasper Knoester addresses our faculty @leidenscience.bsky.social in his New Year's speech. Interesting insights into the future strategic goals of our faculty and great to hear him highlight the priority themes including the @led3hub.bsky.social with new theme leader @mvdstelt.bsky.social.
January 6, 2026 at 2:48 PM
Our dean Jasper Knoester addresses our faculty @leidenscience.bsky.social in his New Year's speech. Interesting insights into the future strategic goals of our faculty and great to hear him highlight the priority themes including the @led3hub.bsky.social with new theme leader @mvdstelt.bsky.social.
2025 was a year full of great scientific discoveries and breakthroughs. Here, I want to highlight 10 papers that got me really excited. Of course, this is a highly subjective selection and I am sure I am forgetting some papers that I would love to include, but here it goes: (1/12)
January 4, 2026 at 6:44 AM
2025 was a year full of great scientific discoveries and breakthroughs. Here, I want to highlight 10 papers that got me really excited. Of course, this is a highly subjective selection and I am sure I am forgetting some papers that I would love to include, but here it goes: (1/12)
Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
pubs.acs.org/doi/10....
#ChemSky #ChemBio #DrugDiscovery #Kinases
pubs.acs.org/doi/10....
#ChemSky #ChemBio #DrugDiscovery #Kinases
December 29, 2025 at 2:00 PM
Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
pubs.acs.org/doi/10....
#ChemSky #ChemBio #DrugDiscovery #Kinases
pubs.acs.org/doi/10....
#ChemSky #ChemBio #DrugDiscovery #Kinases
If you are a #PhD candidate, you can also apply for our meeting award to get 500 € to support your conference attendance and a year of free @gdchbiochem.bsky.social membership. (2/2)
en.gdch.de/network-stru...
#ChemSky #ChemBio #Meeting #Conference #Biochemistry
en.gdch.de/network-stru...
#ChemSky #ChemBio #Meeting #Conference #Biochemistry
December 23, 2025 at 6:53 AM
If you are a #PhD candidate, you can also apply for our meeting award to get 500 € to support your conference attendance and a year of free @gdchbiochem.bsky.social membership. (2/2)
en.gdch.de/network-stru...
#ChemSky #ChemBio #Meeting #Conference #Biochemistry
en.gdch.de/network-stru...
#ChemSky #ChemBio #Meeting #Conference #Biochemistry
Interesting article by the American Peptide Society about the recent publication by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social on using BindCraft to predict #peptide binders to high value protein targets.
americanpeptidesociety.org/aps-news/bin...
americanpeptidesociety.org/aps-news/bin...
December 21, 2025 at 5:29 AM
Interesting article by the American Peptide Society about the recent publication by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social on using BindCraft to predict #peptide binders to high value protein targets.
americanpeptidesociety.org/aps-news/bin...
americanpeptidesociety.org/aps-news/bin...
Are you interested in using #ChemBio to study Biology?
Uni Konstanz and Uni Wien have a new research program on "Chemical and Biological Principles of Cellular Trigger Responses” with 20 PhD positions: www.chembiol.uni-konstanz.de/about-us/app...
#Chemistry #Biology #ChemBio #Trigger #PhD #postdoc
Uni Konstanz and Uni Wien have a new research program on "Chemical and Biological Principles of Cellular Trigger Responses” with 20 PhD positions: www.chembiol.uni-konstanz.de/about-us/app...
#Chemistry #Biology #ChemBio #Trigger #PhD #postdoc
December 19, 2025 at 2:53 PM
Are you interested in using #ChemBio to study Biology?
Uni Konstanz and Uni Wien have a new research program on "Chemical and Biological Principles of Cellular Trigger Responses” with 20 PhD positions: www.chembiol.uni-konstanz.de/about-us/app...
#Chemistry #Biology #ChemBio #Trigger #PhD #postdoc
Uni Konstanz and Uni Wien have a new research program on "Chemical and Biological Principles of Cellular Trigger Responses” with 20 PhD positions: www.chembiol.uni-konstanz.de/about-us/app...
#Chemistry #Biology #ChemBio #Trigger #PhD #postdoc
Great news in the fight against antimicrobial resistance!
Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4)
www.fda.gov/news-events/...
Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4)
www.fda.gov/news-events/...
December 19, 2025 at 12:09 PM
Great news in the fight against antimicrobial resistance!
Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4)
www.fda.gov/news-events/...
Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4)
www.fda.gov/news-events/...
In the last session of the #iCNS meeting, we learned about the research of Work Package 5 on "Target validation in advanced model systems". Great to see the many advanced biological systems that are available for experiments within this consortium.
i-cns.nl/en/research/...
i-cns.nl/en/research/...
December 16, 2025 at 3:32 PM
In the last session of the #iCNS meeting, we learned about the research of Work Package 5 on "Target validation in advanced model systems". Great to see the many advanced biological systems that are available for experiments within this consortium.
i-cns.nl/en/research/...
i-cns.nl/en/research/...
Great talk by Martijn Verdoes at the #iCNS meeting. He talked about the exciting research lines of his group incl. the work on using the ubiquitination machinery to make highly defined, site-specifically modified antibodies.
www.nature.com/articles/s41...
#ChemSky #ChemBio #antibodies #ubiquitin
www.nature.com/articles/s41...
#ChemSky #ChemBio #antibodies #ubiquitin
December 16, 2025 at 3:30 PM
Great talk by Martijn Verdoes at the #iCNS meeting. He talked about the exciting research lines of his group incl. the work on using the ubiquitination machinery to make highly defined, site-specifically modified antibodies.
www.nature.com/articles/s41...
#ChemSky #ChemBio #antibodies #ubiquitin
www.nature.com/articles/s41...
#ChemSky #ChemBio #antibodies #ubiquitin
The #iCNS meeting continues with the presentation of WP2 "Molecular human brain atlas". Interesting insights, into how to select the most relevant material to represent brain regions that are associated with psychiatric disorders and how they can be studied using multi-omics
i-cns.nl/en/research/...
i-cns.nl/en/research/...
December 16, 2025 at 10:26 AM
The #iCNS meeting continues with the presentation of WP2 "Molecular human brain atlas". Interesting insights, into how to select the most relevant material to represent brain regions that are associated with psychiatric disorders and how they can be studied using multi-omics
i-cns.nl/en/research/...
i-cns.nl/en/research/...
Excited to be at the meeting of the Institute for Chemical Neuroscience today. Looking forward to a great day of learning about #neuroscience on the clinical and molecular level as well as to discussing, how chemical tools can drive the field forward
i-cns.nl/en
#ChemSky #ChemBio #ChemicalProteomics
i-cns.nl/en
#ChemSky #ChemBio #ChemicalProteomics
December 16, 2025 at 8:54 AM
Excited to be at the meeting of the Institute for Chemical Neuroscience today. Looking forward to a great day of learning about #neuroscience on the clinical and molecular level as well as to discussing, how chemical tools can drive the field forward
i-cns.nl/en
#ChemSky #ChemBio #ChemicalProteomics
i-cns.nl/en
#ChemSky #ChemBio #ChemicalProteomics
#RSCPoster is happening again on March 3rd and 4th, 2026, here on LinkedIn. I am happy to be involved as subject chair for #RSCChemBio.
If you want to share some exciting research in #Chemistry and especially #ChemBio consider registering for the event:
www.rsc.org/our-events/a...
#ChemSky
If you want to share some exciting research in #Chemistry and especially #ChemBio consider registering for the event:
www.rsc.org/our-events/a...
#ChemSky
December 12, 2025 at 11:50 AM
#RSCPoster is happening again on March 3rd and 4th, 2026, here on LinkedIn. I am happy to be involved as subject chair for #RSCChemBio.
If you want to share some exciting research in #Chemistry and especially #ChemBio consider registering for the event:
www.rsc.org/our-events/a...
#ChemSky
If you want to share some exciting research in #Chemistry and especially #ChemBio consider registering for the event:
www.rsc.org/our-events/a...
#ChemSky
"Drive the Future of Dutch Chemistry with Selfless Leadership"
In July, I had the absolute pleasure to attend the "KNCV – NextGen Leaders in Dutch Chemistry Summit". Here, we had in-depth discussions on Leadership as well as the current state and the future of Chemistry in the Netherlands. (1/11)
In July, I had the absolute pleasure to attend the "KNCV – NextGen Leaders in Dutch Chemistry Summit". Here, we had in-depth discussions on Leadership as well as the current state and the future of Chemistry in the Netherlands. (1/11)
December 12, 2025 at 11:29 AM
"Drive the Future of Dutch Chemistry with Selfless Leadership"
In July, I had the absolute pleasure to attend the "KNCV – NextGen Leaders in Dutch Chemistry Summit". Here, we had in-depth discussions on Leadership as well as the current state and the future of Chemistry in the Netherlands. (1/11)
In July, I had the absolute pleasure to attend the "KNCV – NextGen Leaders in Dutch Chemistry Summit". Here, we had in-depth discussions on Leadership as well as the current state and the future of Chemistry in the Netherlands. (1/11)
#NWOCHAINS comes to an end with the closing ceremony led by Ioana Ilie (@biosim-lab.bsky.social)!
I had two days of exciting science and learned a lot. Thank you to everyone, who was involved in organizing and who contributed to the program. Congratulations to all winners of the poster prizes!
I had two days of exciting science and learned a lot. Thank you to everyone, who was involved in organizing and who contributed to the program. Congratulations to all winners of the poster prizes!
December 3, 2025 at 8:10 PM
#NWOCHAINS comes to an end with the closing ceremony led by Ioana Ilie (@biosim-lab.bsky.social)!
I had two days of exciting science and learned a lot. Thank you to everyone, who was involved in organizing and who contributed to the program. Congratulations to all winners of the poster prizes!
I had two days of exciting science and learned a lot. Thank you to everyone, who was involved in organizing and who contributed to the program. Congratulations to all winners of the poster prizes!
Interesting talk by Florian Ort from the group of Floris Rutjes at #NWOCHAINS. He talked about the use of #mechanochemistry for solvent-free, racemization-free #peptide #ligation. Exciting applications for #NativeChemicalLigation of insoluble peptides.
#ChemSky #ChemBio #GreenChemistry
#ChemSky #ChemBio #GreenChemistry
December 3, 2025 at 2:46 PM
Interesting talk by Florian Ort from the group of Floris Rutjes at #NWOCHAINS. He talked about the use of #mechanochemistry for solvent-free, racemization-free #peptide #ligation. Exciting applications for #NativeChemicalLigation of insoluble peptides.
#ChemSky #ChemBio #GreenChemistry
#ChemSky #ChemBio #GreenChemistry
Very happy that @marnixroseboom.bsky.social represented our group of the @led3hub.bsky.social with a very well-attended talk at #NWOCHAINS. He reported on his #PhD work on developing #ChemoProteomics technologies to study #CovalentInhibitor target engagement at arginines.
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
December 3, 2025 at 2:28 PM
Very happy that @marnixroseboom.bsky.social represented our group of the @led3hub.bsky.social with a very well-attended talk at #NWOCHAINS. He reported on his #PhD work on developing #ChemoProteomics technologies to study #CovalentInhibitor target engagement at arginines.
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
Interesting talk by Foteini Skoulikopoulou of the group of @armstrongchembio.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. She talked about her research into the synthesis of stable 9-O-acetylated sialic acid mimics with potential applications as #antivirals.
#glycotime #ChemSky #ChemBio
#glycotime #ChemSky #ChemBio
December 3, 2025 at 2:13 PM
Interesting talk by Foteini Skoulikopoulou of the group of @armstrongchembio.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. She talked about her research into the synthesis of stable 9-O-acetylated sialic acid mimics with potential applications as #antivirals.
#glycotime #ChemSky #ChemBio
#glycotime #ChemSky #ChemBio
Interesting talk by Friedrich Förster at #NWOCHAINS. He talked about his group's exciting research into visualizing protein biogenesis at the ER membrane using cryo-electron microscopy and cryo-electron tomography.
www.nature.com/articles/s41...
#cryoEM #proteins #structure
www.nature.com/articles/s41...
#cryoEM #proteins #structure
December 3, 2025 at 2:07 PM
Interesting talk by Friedrich Förster at #NWOCHAINS. He talked about his group's exciting research into visualizing protein biogenesis at the ER membrane using cryo-electron microscopy and cryo-electron tomography.
www.nature.com/articles/s41...
#cryoEM #proteins #structure
www.nature.com/articles/s41...
#cryoEM #proteins #structure
Another great session of #PosterPitches at #NWOCHAINS. We learned about a huge diversity of topics including #SupramoecularAssemblies, #biomarker #sensing, #Ion-selective #membranes, radical #polymerization and #MassSpectrometry.
December 3, 2025 at 2:06 PM
Another great session of #PosterPitches at #NWOCHAINS. We learned about a huge diversity of topics including #SupramoecularAssemblies, #biomarker #sensing, #Ion-selective #membranes, radical #polymerization and #MassSpectrometry.
@seanmckenna.bsky.social represented the group of @sebastianpomplun.bsky.social and the @led3hub.bsky.social with an exciting talk at #NWOCHAINS. He talked about using a combination of in silico screening and semi-automated synthesis to accelerate #DrugDiscovery.
#ChemSky #ChemBio
#ChemSky #ChemBio
December 3, 2025 at 1:59 PM
@seanmckenna.bsky.social represented the group of @sebastianpomplun.bsky.social and the @led3hub.bsky.social with an exciting talk at #NWOCHAINS. He talked about using a combination of in silico screening and semi-automated synthesis to accelerate #DrugDiscovery.
#ChemSky #ChemBio
#ChemSky #ChemBio
Excited that Yorick van Aalst represented our group of the @led3hub.bsky.social with a talk at #NWOCHAINS. He talked about mining #AlphaFold structures of the entire proteome for pockets and using this information to prioritize hits from #Chemoproteomic screens.
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
December 3, 2025 at 1:55 PM
Excited that Yorick van Aalst represented our group of the @led3hub.bsky.social with a talk at #NWOCHAINS. He talked about mining #AlphaFold structures of the entire proteome for pockets and using this information to prioritize hits from #Chemoproteomic screens.
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
Exciting talk by Charalampos Ntallis from the group of Markus Weingarth at #NWOCHAINS. He talked about his exciting research into using solid-state #NMR to understand the interaction between the last resort #antibiotic #polymyxin and #LPS on the molecular level.
December 3, 2025 at 1:50 PM
Exciting talk by Charalampos Ntallis from the group of Markus Weingarth at #NWOCHAINS. He talked about his exciting research into using solid-state #NMR to understand the interaction between the last resort #antibiotic #polymyxin and #LPS on the molecular level.
Insightful talk by Bob van Puffelen from the groups of Jeroen Codee and Dima Filippov @leidenadpr.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. He talked about a glycan modification of the bacterial flagellum and how they use synthetic tools to study its biosynthesis.
#ChemSky #ChemBio
#ChemSky #ChemBio
December 3, 2025 at 1:47 PM
Insightful talk by Bob van Puffelen from the groups of Jeroen Codee and Dima Filippov @leidenadpr.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. He talked about a glycan modification of the bacterial flagellum and how they use synthetic tools to study its biosynthesis.
#ChemSky #ChemBio
#ChemSky #ChemBio