Huge thanks to all involved, including but not limited to
@jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @nartimsoole.bsky.social @arnemoeller.bsky.social

With a combination of #cryo-EM, biochemical, biophysical and in vivo data we show what contributes to substrate and target membrane specificity and reveal a function of the third subunit of the metazoan MC1 GEF, RMC1/Bulli.

Thrilled to share our newest publication in Science Advances!
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....

Always found it odd we were never thaught how to assess publications. Of course your experiences, discussion and reading loads are key, but I think a reminder on Master's level that not everything you come across in literature can be taken for granted and what to look for would help lots of students

Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1...
Happy testing: cryosift.org #cryoEM #CNN

Happy our preprint on the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned is out! doi.org/10.1101/2025...
Thanks to everyone involved! @jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @arnemoeller.bsky.social @nartimsoole.bsky.social

Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned https://www.biorxiv.org/content/10.1101/2025.03.27.645700v1

Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1