Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

Exited to share our recent work on viral cis-regulatory elements in collaboration with @tewhey.bsky.social!
We identified >2000 CREs across the genomes of 27 human-infecting dsDNA viruses from the Herpesvirus, Adenovirus, Papillomavirus, and Polyomavirus families.
www.biorxiv.org/content/10.1...
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Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU

Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542...

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1/n 🚨Very excited to share our recent work!🚨
To understand gene regulation across diverse environmental conditions and cellular contexts, we treated a broad array of human cell types with three environmental exposures in vitro.
www.biorxiv.org/content/10.1...

Proud to share our lab’s first student preprint!🚀@j-c-butts.bsky.social, @alwaysrong.bsky.social, @sagergosai.bsky.social leveraged our MPRA models to predict variant effects, providing scores for the complete catalog of human variation. Grateful for another fun collab with @stevereilly.bsky.social.

In 15 yrs of reporting, I've never had so many health & biomed researchers & outreach orgs tell me they're afraid to talk w/press or barred from speaking bc of new comms policies.

I understand the fear of losing funds. I don't know if silence does more harm than good. If you can speak up, pls do.

A special Bluetorial about one of my mentors Ruth Kirschstein

Among Ruth Kirschstein’s many contributions to American science was the development and expansion of programs intended to increase participation of people from groups underrepresented in biomedical research.

Super excited to announce our latest flagship model Borzoi: major props to Johannes & David Kelley et al for advancing it. It's been a long journey from our prior Enformer model into this one. A few innovations: i) longer DNA context, ii) adaptation to predict RNA-seq abundance and splice isoforms,

Our ChromBPNet preprint out!

www.biorxiv.org/content/10.1...

Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/

Thanks @stephenturner.us for highlighting our work!