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thecimr.bsky.social
Cambridge Institute for Medical Research
@thecimr.bsky.social
280 followers 110 following 34 posts
An interdisciplinary institute within University of Cambridge School of Clinical Medicine Determining the molecular mechanisms of human disease, focusing on genetic/ pathogen-induced disruptions to fundamental cellular pathways https://www.cimr.cam.ac.uk/
www.cimr.cam.ac.uk
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jan 16
Hello! Although we are still in the other place, this will become our main social media feed. We're part of the University of Cambridge Clinical School
Cell biology, molecular mechanisms of human disease
Colourful microscope image of malaria parasites infecting human red blood cells. Rayner lab Con-focal microscope image of glutamatergic neurons with axons labelled in yellow/ orange and somatodendritic compartments in blue. Nixon-Abell lab at CIMR
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · 1d
Applications now open for our work experience programme for year 12 students, run with @mrc-mbu.bsky.social & @stcatharines.bsky.social We give students a valuable insight into life as a research scientist and student in Cambridge. Details & application link here: www.cimr.cam.ac.uk/inspiring-sc...
A montage of images of sixth form students in a Cambridge research lab
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · 1d
Great to welcome our second cohort of students to our Masters in Molecular Mechanism of Human Disease today. Have a good year everyone!
Group of university students gathered on a staircase and landing
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · 9d
We're looking forward to the Big Biology Day at Hills Road Sixth Form on Saturday 11th October - who's coming?
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Reposted by Cambridge Institute for Medical Research
jennydickens41.bsky.social
Jenny Dickens @jennydickens41.bsky.social · 13d
*job alert**
Wanted - 2 enthusiastic postdocs to join me @thecimr.bsky.social and Emma Rawlins @labrawlins.bsky.social to build complex models and use -omic approaches to understand mechanisms in human lung disease in collaboration with GSK. Contact us for more info!
www.jobs.cam.ac.uk/job/52936/
Research Associate: Human Lung Disease Mechanisms (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate: Human Lung Disease Mechanisms (Fixed Term) in the Gurdon Institute at the University of Cambridge.
www.jobs.cam.ac.uk
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · 22d
Great new paper highlighting @jenniferepalmer.bsky.social 's PhD work: www.cimr.cam.ac.uk/research-adv...
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Reposted by Cambridge Institute for Medical Research
jcellsci.bsky.social
Journal of Cell Science @jcellsci.bsky.social · 28d
New JCS snapshot - Cytotoxic T lymphocytes adapt to the loss of Cdc42
@adamrochussen.bsky.social presents the key findings from their recent JCS paper with Claire Ma and Gillian Griffiths @griffithslab.bsky.social.
journals.biologists.com/jcs/article/...
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Reposted by Cambridge Institute for Medical Research
genomicpress.bsky.social
Genomic Press @genomicpress.bsky.social · Aug 21
🧠 Cambridge scientist reveals how autophagy clears toxic proteins in neurodegeneration in Genomic Press Interview. Dr. Rubinsztein's breakthrough: cellular cleanup fights Huntington's, Parkinson's & Alzheimer's! 134k+ citations 🔬✨
📄🆓 DOI: doi.org/10.61373/bm0...
Source: genomicpress.kglmeridian.com
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Reposted by Cambridge Institute for Medical Research
jcellsci.bsky.social
Journal of Cell Science @jcellsci.bsky.social · Aug 11
. @adamrochussen.bsky.social, Claire Ma & Gillian Griffiths @griffithslab.bsky.social find that deletion of Cdc42 in primary T cells triggers transcriptional adaptation, leading to enhanced T cell function.
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Multi-panel figure showing that CTL function improves days after deletion of Cdc42.
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Reposted by Cambridge Institute for Medical Research
griffithslab.bsky.social
Griffiths Lab @griffithslab.bsky.social · Aug 4
Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...

In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
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Reposted by Cambridge Institute for Medical Research
profmarciniak.bsky.social
Stefan Marciniak @profmarciniak.bsky.social · Aug 1
Great news² 🥳

Clinical PhD student Niki Veale has just passed his PhD viva so will become Dr Dr Veale (Dr² Veale)

We’ve also learned that he’s secured a Clinical Lectureship so will return to the lab as a post-doc (or is that post-doc-doc?)

@thecimr.bsky.social
@veale-n.bsky.social
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 24
Congratulations Adam!
adamrochussen.bsky.social
Adam Rochussen @adamrochussen.bsky.social · Jul 21
Delighted to have been awarded a CSAR 2025 PhD Student Award for some of my work in the @griffithslab.bsky.social
@thecimr.bsky.social

The CSAR mission to recognise and prioritise research with real-world application is a super important one that I'll be taking forward as a postdoc & beyond
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Reposted by Cambridge Institute for Medical Research
jennydickens41.bsky.social
Jenny Dickens @jennydickens41.bsky.social · Jul 22
New preprint alert! Endogenous gene editing of alveolar organoids to investigate mechanisms of epithelial dysfunction in familial ILD. Kudos first author @eimearrutherford.bsky.social and thanks @thecimr.bsky.social @labrawlins.bsky.social @profmarciniak.bsky.social
www.biorxiv.org/content/10.1...
Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing
Background: Idiopathic pulmonary fibrosis is a fatal lung disease of progressive lung parenchymal scarring caused by the aberrant response of an alveolar epithelium repeatedly exposed to injury. Under...
www.biorxiv.org
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 17
Could climate change bring new diseases to the UK? Prof Michael Weekes spoke to @the-independent.com recently
www.independent.co.uk/climate-chan...
Heatwaves could bring deadly ‘tropical’ diseases to Britain
A warming world is pushing tropical infectious diseases northwards as pathogens thrive in hot and humid conditions
www.independent.co.uk
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 15
We had a such a great week with this lovely group of students on @gurdoninstitute.bsky.social ASTP programme- they did some fantastic presentations on Friday! Well done to all of them 👋👋👋
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Reposted by Cambridge Institute for Medical Research
saraocana1.bsky.social
Sara Cuevas Ocaña @saraocana1.bsky.social · Jul 12
Such a rewarding experience to host these ASTP students and guide them through an exciting weak of science discovery @thecimr.bsky.social
I’m glad I could convey the importance of sterile conditions in cell culture 😂😂
thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 10
We're loving hosting students for the @gurdoninstitute.bsky.social ASTP programme, along with @mrc-mbu.bsky.social . As ever, so impressed with the next generation of scientists!
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 10
We're loving hosting students for the @gurdoninstitute.bsky.social ASTP programme, along with @mrc-mbu.bsky.social . As ever, so impressed with the next generation of scientists!
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 7
Rounding up today's flurry of new papers is this one from the Salje lab www.cimr.cam.ac.uk/research-adv...
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 7
And another one from the very busy @deanelab.bsky.social - this time PhD work from Alex Nicholson
www.cimr.cam.ac.uk/research-adv...
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 7
New in from @deanelab.bsky.social www.nature.com/articles/s41...
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 3
New insights from the Salje lab into the little-known but common Scrub typhus - a vector-borne human disease caused by the bacterium Orientia tsutsugmushi and spread by mites: www.cimr.cam.ac.uk/research-adv...
Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease | Cambridge Institute for Me...
Scrub typhus is a vector-borne human disease caused by the bacterium Orientia tsutsugmushi and spread by mites.
www.cimr.cam.ac.uk
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thecimr.bsky.social
Cambridge Institute for Medical Research @thecimr.bsky.social · Jul 1
Great new paper from the Rubinsztein lab www.cimr.cam.ac.uk/research-adv...
Reposted by Cambridge Institute for Medical Research
mrclmb.bsky.social
MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Jun 17
Is the next step of your career at the LMB?
Come and find us at the @cambridgebiocampus.bsky.social Campus Jobs and Career Fair this Saturday 21st June at the Cambridge Academy for Science and Technology!
More details here: cambridge-biomedical.com/event/cbc-jo...
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Reposted by Cambridge Institute for Medical Research
crukcamcentre.bsky.social
Cancer Research UK Cambridge Centre @crukcamcentre.bsky.social · Jun 12
Join @crukcamthoracic.bsky.social For the launch event of 'NextGen Researchers'. A great opportunity to connect with like-minded early career cancer researchers in Cambridge!

📅 Thursday 10 July, 5-6pm
🍕 Pizza provided
📍@vpd-hlri.bsky.social
Register ➡️ www.eventbrite.co.uk/e/nextgen-re...
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Reposted by Cambridge Institute for Medical Research
lautenschlagerlab.bsky.social
lautenschlagerlab.bsky.social @lautenschlagerlab.bsky.social · Jun 12
Very excited to share our second preprint from the lab ‘Dual effect of alpha-synuclein disease variants on condensate formation’

www.biorxiv.org/content/10.1...

Great work from Aswathy, Aishwarya, Tianhao and our collaborator Tiago Outeiro. Thanks to @thecimr.bsky.social and @royalsociety.org.
Dual effect of alpha-synuclein disease variants on condensate formation
Alpha-synuclein is a pre-synaptic protein implicated in synucleinopathies like Parkinson's disease and Dementia with Lewy Bodies, where it accumulates in intracellular aggregates termed Lewy bodies an...
www.biorxiv.org
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Reposted by Cambridge Institute for Medical Research
crukcamcentre.bsky.social
Cancer Research UK Cambridge Centre @crukcamcentre.bsky.social · Jun 3
📢 Don’t miss our next Cancer Biology and Medicine talk on Thursday!

Early cancer trials
Dr Simon Pacey @cuh.nhs.uk

Thurs 5 June, 9:30-10:30
TC Lecture Theatre, School of Clinical Medicine
All welcome @cambridge-scm.bsky.social
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