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Joe Bondy-Denomy @jbdsf.bsky.social · 14d

Our Department of Microbiology & Immunology at UCSF is running a faculty search this year for a new Assistant Professor! Please see the ad below for details. Searching for a great colleague, mentor, and scientist!
aprecruit.ucsf.edu/JPF05807

Microbiology and Immunology – Faculty Position (Ladder Rank) – Assistant Professor

University of California, San Francisco is hiring. Apply now!

aprecruit.ucsf.edu

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Anthony Vecchiarelli @cellforganized.bsky.social · 16d

New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵

Collaboration with the Giessen and Pi labs

Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!

www.biorxiv.org/content/10.1...

Engineering Spatial Control of Bacterial Organelles

Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...

www.biorxiv.org

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The Thormann Lab @thethormannden.bsky.social · 20d

Thanks for having us on board, Khaled!

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Ákos T Kovács @evolvedbiofilm.bsky.social · 20d

And here is the published version of the work from @selimlab.bsky.social, @mygalperin.bsky.social, Dubnau labs and @thethormannden.bsky.social labs
(superb collaboration)

ComFB, a widespread family of c-di-NMP receptor proteins

www.pnas.org/doi/10.1073/...

ComFB, a widespread family of c-di-NMP receptor proteins | PNAS

Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates a variety of cellular processes, including motility, biofil...

www.pnas.org

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Sonja-Verena Albers @archaellum.bsky.social · 22d

Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social

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Eduardo Rocha @epcrocha.bsky.social · Sep 8

Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...

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Royal Society Publishing @royalsocietypublishing.org · Sep 5

A new theme issue of #PhilTransB examines the evolutionary history of bacterial immune systems, their modes of action, and the patterns how different bacterial immune systems are distributed across different ecosystems. Read: buff.ly/Z4qdxY1

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The Thormann Lab @thethormannden.bsky.social · Sep 6

Morning stroll in early fall.

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Kranzusch Lab @kranzuschlab.bsky.social · Sep 5

How can we understand the earliest events in evolution of eukaryotic immunity? @yao-li.bsky.social reports incredible molecular fossils of complete bacterial-like operons in eukaryotes that illuminate how animal immunity was first acquired from anti-phage defense

www.biorxiv.org/content/10.1...

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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · Sep 5

Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team.
www.nature.com/articles/s41...

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Ákos T Kovács @evolvedbiofilm.bsky.social · Aug 31

Kin Recognition Systems and Their Role in Multicellular Behaviors

#AnnuRevMicrobiol by Karin Yaniv and Karine Gibbs @ucberkeleyofficial.bsky.social

four bacterial and eukaryotic microorganisms with collective migration where recognition is known or implied

www.annualreviews.org/content/jour...

Kin Recognition Systems and Their Role in Multicellular Behaviors | Annual Reviews

Interactions between individuals are at the foundation of every community. Furthermore, multicellular behaviors can emerge when individuals come together. Microbes—bacteria, fungi, archaea, and parasi...

www.annualreviews.org

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Sorek Lab @soreklab.bsky.social · Aug 25

Preprint: We discovered phage proteins that sequester diverse immune signaling molecules, including cUMP, cCMP, and N7-cADPR

The first viral sponges to inhibit Pycsar and type IV Thoeris

Congrats to talented leading author Romi Hadary! Read her thread to learn more about our findings

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Sonja-Verena Albers @archaellum.bsky.social · Aug 20

🚨 Imagine a bacterium that refuses to follow the textbook:
It grows as tangled filaments, divides unevenly, reshapes its own membranes… and even builds grappling hooks.
Meet Litorilinea aerophila — and here’s why it blew our minds.

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Kranzusch Lab @kranzuschlab.bsky.social · Aug 14

www.nature.com/articles/s41...

Characterization of an amyloid-based antiphage defence system in Escherichia coli - Nature Microbiology

Prion-like proteins in Escherichia coli trigger an abortive infection mechanism in response to phage infection—a process similar to amyloid-mediated immune signalling in fungi and animals.

www.nature.com

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Christian Kost @kostchristian.bsky.social · Aug 8

I am excited to announce that the position of a senior postdoc (3 +3 years) in the field of theoretical biology is available in my group.

The position provides the opportunity to closely interact with experimentalists and develop own research projects.

Please RT.

Details 👇:
shorturl.at/iiiOv

116 FB 5 Research Assistant (m/f/d) field of Theoretical Ecology and Evolution or Computational Biology: Uni Osnabrück

shorturl.at

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Maciek Wiatrak @macwiatrak.bsky.social · Jul 21

💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve.

Preprint 📝: biorxiv.org/content/10.1...

🧵 1/n

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Sorek Lab @soreklab.bsky.social · Jul 30

We wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology

www.nature.com/articles/s41...

Was fun to write this piece with Dina Hochhauser!

Here is a thread to explain the premises

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Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology

Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...

www.nature.com

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Nature Microbiology @natmicrobiol.nature.com · Aug 1

#NatMicroPicks

Ancient Proteins, Modern Immune Insights! 🦠

A conserved protein family member activates inflammation via the Toll-like receptor pathway in mammals highlighting new aspects of human immunity.

www.science.org/doi/10.1126/...

A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway

Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...

www.science.org

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Sternberg Lab @sternberglab.bsky.social · Jul 24

1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77

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Eduardo Rocha @epcrocha.bsky.social · Jul 23

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

graphical abstract of the article the extended mobility of plasmids

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Aude Bernheim @audeber.bsky.social · Jul 24

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

www.science.org

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Rob Edwards @linsalrob.bsky.social · Jul 22

Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

Structural predictions to improve #phage genome annotation!

@hannelorelongin.bsky.social @gbouras13.bsky.social y.social @susiegriggo.bsky.social @veravannoort.bsky.social

www.biorxiv.org/content/10.1...

Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, t...

www.biorxiv.org

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Kranzusch Lab @kranzuschlab.bsky.social · Jul 17

A new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity.

www.biorxiv.org/content/10.1...

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BejaLab @bejalab.bsky.social · Jul 16

Prophages block cell surface receptors to preserve their viral progeny www.nature.com/articles/s41...

Prophages block cell surface receptors to preserve their viral progeny - Nature

Zip promotes the accumulation of free phages in bacterial lysogen communities, safeguarding phage progeny.

www.nature.com

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Yves Brun lab @brunlabcaulo.bsky.social · Jul 9

Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...

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