Anthony Vecchiarelli
@cellforganized.bsky.social
How do bacteria organize their innards?
Associate Prof at UMich
Associate Prof at UMich
Reposted by Anthony Vecchiarelli
I am pleased to announce the submission of my first author manuscript, "Aerotolerant Capacity of the Lung Commensal Prevotella melaninogenica," now available as a preprint.
🧫🧫🧫
Thank you to my mentors Dr. Ariangela Kozik @drkozik.bsky.social and Dr. Gary Huffnagle at UM.
🧫🧫🧫
Thank you to my mentors Dr. Ariangela Kozik @drkozik.bsky.social and Dr. Gary Huffnagle at UM.
Aerotolerant Capacity of the Lung Commensal Prevotella melaninogenica https://www.biorxiv.org/content/10.64898/2026.01.19.700327v1
January 24, 2026 at 3:19 AM
I am pleased to announce the submission of my first author manuscript, "Aerotolerant Capacity of the Lung Commensal Prevotella melaninogenica," now available as a preprint.
🧫🧫🧫
Thank you to my mentors Dr. Ariangela Kozik @drkozik.bsky.social and Dr. Gary Huffnagle at UM.
🧫🧫🧫
Thank you to my mentors Dr. Ariangela Kozik @drkozik.bsky.social and Dr. Gary Huffnagle at UM.
Reposted by Anthony Vecchiarelli
Pyrenoid Structure, Function, Evolution, and Characterization Across Diverse Lineages.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Pyrenoid Structure, Function, Evolution, and Characterization Across Diverse Lineages
Pyrenoids are eukaryotic CO2-fixing organelles that are evolutionarily diverse, globally abundant, and critical to global carbon cycling. Despite being described over 200 years ago, the vast majority ...
www.annualreviews.org
January 17, 2026 at 2:22 AM
Pyrenoid Structure, Function, Evolution, and Characterization Across Diverse Lineages.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Reposted by Anthony Vecchiarelli
We resolved the molecular architecture of a condensate—inside cells. 🤯 By combining in situ cryoET with multiscale simulations, we show how a single point mutation modifies molecular interactions, shifts the condensate’s material properties, and alters its biological function. Preprint 👇
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
January 13, 2026 at 6:33 PM
We resolved the molecular architecture of a condensate—inside cells. 🤯 By combining in situ cryoET with multiscale simulations, we show how a single point mutation modifies molecular interactions, shifts the condensate’s material properties, and alters its biological function. Preprint 👇
Reposted by Anthony Vecchiarelli
🚨PREPRINT🚨
Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.
#OXA-48 #ceftazidime #enzymeevolution
www.biorxiv.org/content/10.6...
Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.
#OXA-48 #ceftazidime #enzymeevolution
www.biorxiv.org/content/10.6...
Evolution tunes functional sub-state interconversion to boost enzyme function
Enzymes do not operate as static structures, but continuously fluctuate between different conformations. Enzymes therefore dynamically sample conformations with varying catalytic activity. However, it...
www.biorxiv.org
January 1, 2026 at 10:26 AM
🚨PREPRINT🚨
Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.
#OXA-48 #ceftazidime #enzymeevolution
www.biorxiv.org/content/10.6...
Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.
#OXA-48 #ceftazidime #enzymeevolution
www.biorxiv.org/content/10.6...
Reposted by Anthony Vecchiarelli
I am beyond excited to announce that the Bisson Lab has a new home!!! Starting January 2026, I will join the Biology Department at Indiana University Bloomington as Associate Professor with tenure.
I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join
[1/4]
I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join
[1/4]
December 24, 2025 at 5:10 PM
I am beyond excited to announce that the Bisson Lab has a new home!!! Starting January 2026, I will join the Biology Department at Indiana University Bloomington as Associate Professor with tenure.
I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join
[1/4]
I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join
[1/4]
Reposted by Anthony Vecchiarelli
Can’t wait!! My bacterial cell bio friends, you’re gonna want to go to this GRC and GRS.
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
December 13, 2025 at 1:44 PM
Can’t wait!! My bacterial cell bio friends, you’re gonna want to go to this GRC and GRS.
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
December 12, 2025 at 2:58 PM
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
Reposted by Anthony Vecchiarelli
NSF
- Forced reorg
- POs down ~ 40% (DRP, most rotators not renewed, retirements)
- Forced move (and we have to pack and clean) to a building with no furniture, little to no conference space for panels, inadequate 🛜, …)
I personally love the boxes they gave us for packing.
“Details matter” 🙃
- Forced reorg
- POs down ~ 40% (DRP, most rotators not renewed, retirements)
- Forced move (and we have to pack and clean) to a building with no furniture, little to no conference space for panels, inadequate 🛜, …)
I personally love the boxes they gave us for packing.
“Details matter” 🙃
December 11, 2025 at 11:16 AM
NSF
- Forced reorg
- POs down ~ 40% (DRP, most rotators not renewed, retirements)
- Forced move (and we have to pack and clean) to a building with no furniture, little to no conference space for panels, inadequate 🛜, …)
I personally love the boxes they gave us for packing.
“Details matter” 🙃
- Forced reorg
- POs down ~ 40% (DRP, most rotators not renewed, retirements)
- Forced move (and we have to pack and clean) to a building with no furniture, little to no conference space for panels, inadequate 🛜, …)
I personally love the boxes they gave us for packing.
“Details matter” 🙃
Reposted by Anthony Vecchiarelli
📄 Delighted to share that the preprint of my main PhD work is out now!
👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏
🧵 below!
www.biorxiv.org/content/10.6...
👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏
🧵 below!
www.biorxiv.org/content/10.6...
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems
Low-copy-number plasmids often rely on dedicated maintenance mechanisms, such as partitioning systems, to ensure stable inheritance across generations. These partition systems actively segregate siste...
www.biorxiv.org
December 11, 2025 at 1:25 PM
📄 Delighted to share that the preprint of my main PhD work is out now!
👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏
🧵 below!
www.biorxiv.org/content/10.6...
👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏
🧵 below!
www.biorxiv.org/content/10.6...
Reposted by Anthony Vecchiarelli
Fabulous summer research opportunity for undergraduate students.
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
bit.ly
November 30, 2025 at 12:13 AM
Fabulous summer research opportunity for undergraduate students.
Reposted by Anthony Vecchiarelli
🚨Announcing the NSF-NIST Bioeconomy Standards Scholar-in-Residence Initiative.
👉🏻Catalyze development of standards and metrics for the bioeconomy.
👉🏻Researchers spend time in a NIST laboratory to gain experience and help this initiative.
www.nsf.gov/funding/oppo...
👉🏻Catalyze development of standards and metrics for the bioeconomy.
👉🏻Researchers spend time in a NIST laboratory to gain experience and help this initiative.
www.nsf.gov/funding/oppo...
NSF-NIST Scholars in Residence
www.nsf.gov
November 22, 2025 at 1:08 AM
🚨Announcing the NSF-NIST Bioeconomy Standards Scholar-in-Residence Initiative.
👉🏻Catalyze development of standards and metrics for the bioeconomy.
👉🏻Researchers spend time in a NIST laboratory to gain experience and help this initiative.
www.nsf.gov/funding/oppo...
👉🏻Catalyze development of standards and metrics for the bioeconomy.
👉🏻Researchers spend time in a NIST laboratory to gain experience and help this initiative.
www.nsf.gov/funding/oppo...
Reposted by Anthony Vecchiarelli
Bacterial networks #BacNet26 in September 2026 will be chaired by @lalouxlab.bsky.social and co-chaired by @s-lab.bsky.social with @coralietesseur.bsky.social
Sneak peak on invited speakers and preliminary program:
meetings.embo.org/event/26-bac...
Sneak peak on invited speakers and preliminary program:
meetings.embo.org/event/26-bac...
November 20, 2025 at 8:47 AM
Bacterial networks #BacNet26 in September 2026 will be chaired by @lalouxlab.bsky.social and co-chaired by @s-lab.bsky.social with @coralietesseur.bsky.social
Sneak peak on invited speakers and preliminary program:
meetings.embo.org/event/26-bac...
Sneak peak on invited speakers and preliminary program:
meetings.embo.org/event/26-bac...
Reposted by Anthony Vecchiarelli
Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB https://www.biorxiv.org/content/10.1101/2025.11.19.689047v1
November 19, 2025 at 4:18 PM
Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB https://www.biorxiv.org/content/10.1101/2025.11.19.689047v1
Reposted by Anthony Vecchiarelli
I’m excited to share my recent postdoc work. Here, we interrogate how different phage infection outcomes (productive vs. restrictive) affect the expression of phage defense systems. We find that a restricted infection not only inhibits the phage but also induces increased immune protein abundance.
Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses https://www.biorxiv.org/content/10.1101/2025.11.13.688357v1
November 15, 2025 at 6:10 PM
I’m excited to share my recent postdoc work. Here, we interrogate how different phage infection outcomes (productive vs. restrictive) affect the expression of phage defense systems. We find that a restricted infection not only inhibits the phage but also induces increased immune protein abundance.
Reposted by Anthony Vecchiarelli
Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
doi.org
July 2, 2025 at 10:07 AM
Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
Reposted by Anthony Vecchiarelli
Trump’s HHS put me on “non-disciplinary” admin leave today. This was retaliation for speaking up. Moves like this are designed to silence us. Let’s not let.
www.tiktok.com/t/ZP8Dteoop/
www.tiktok.com/t/ZP8Dteoop/
I guess I am hitting a nerve, because they just put me on admin leave.
TikTok video by Jenna
www.tiktok.com
November 13, 2025 at 11:18 PM
Trump’s HHS put me on “non-disciplinary” admin leave today. This was retaliation for speaking up. Moves like this are designed to silence us. Let’s not let.
www.tiktok.com/t/ZP8Dteoop/
www.tiktok.com/t/ZP8Dteoop/
Reposted by Anthony Vecchiarelli
NSF is open again!
A few comments:
*Please be patient.
During a shutdown NSF employees cannot open computers or respond to emails.
*Merit review will continue. However panels won’t resume until after Dec 8th.
*POs remain excited and committed to advancing science and the scientific workforce.
A few comments:
*Please be patient.
During a shutdown NSF employees cannot open computers or respond to emails.
*Merit review will continue. However panels won’t resume until after Dec 8th.
*POs remain excited and committed to advancing science and the scientific workforce.
November 13, 2025 at 5:58 PM
NSF is open again!
A few comments:
*Please be patient.
During a shutdown NSF employees cannot open computers or respond to emails.
*Merit review will continue. However panels won’t resume until after Dec 8th.
*POs remain excited and committed to advancing science and the scientific workforce.
A few comments:
*Please be patient.
During a shutdown NSF employees cannot open computers or respond to emails.
*Merit review will continue. However panels won’t resume until after Dec 8th.
*POs remain excited and committed to advancing science and the scientific workforce.
Reposted by Anthony Vecchiarelli
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
November 10, 2025 at 6:15 PM
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
Reposted by Anthony Vecchiarelli
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
November 11, 2025 at 1:20 AM
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
Canadian Premier Soccer final is the most bad ass soccer game I've seen.
soccer players are playing in the snow with a sign that says season tick
ALT: soccer players are playing in the snow with a sign that says season tick
media.tenor.com
November 10, 2025 at 1:07 AM
Canadian Premier Soccer final is the most bad ass soccer game I've seen.
Reposted by Anthony Vecchiarelli
Friday means a new #MattersMicrobial podcast. This week, Dr. Hannah Ledvina joins the #QualityQuorum to chat about how bacteria can shield themselves against Bdellovibrio attack! Please spread the #GoodMicrobialWord. @univpugetsound @ASMicrobiology @microbe.tv
youtu.be/n31kkw576GE?...
youtu.be/n31kkw576GE?...
November 7, 2025 at 6:03 PM
Friday means a new #MattersMicrobial podcast. This week, Dr. Hannah Ledvina joins the #QualityQuorum to chat about how bacteria can shield themselves against Bdellovibrio attack! Please spread the #GoodMicrobialWord. @univpugetsound @ASMicrobiology @microbe.tv
youtu.be/n31kkw576GE?...
youtu.be/n31kkw576GE?...
Reposted by Anthony Vecchiarelli
One of the most useful resources for anyone who uses fluorescence methods.
The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!
www.fpbase.org/spectra/
www.fpbase.org/spectra/
FPbase Fluorescence Spectra Viewer
An interactive fluorescence spectra viewer to evaluate the spectral properties of fluorescent proteins, organic dyes, filters, and detectors.
www.fpbase.org
November 4, 2025 at 5:01 PM
One of the most useful resources for anyone who uses fluorescence methods.
Reposted by Anthony Vecchiarelli
Right now this is my favorite @inaturalist.bsky.social observation www.inaturalist.org/observations...
Blue Jay (Cyanocitta cristata)
Blue Jay from Montgomery County, MD, USA on January 18, 2024 at 10:35 AM by Jonathan Eisen
www.inaturalist.org
November 2, 2025 at 2:37 AM
Right now this is my favorite @inaturalist.bsky.social observation www.inaturalist.org/observations...
Reposted by Anthony Vecchiarelli
I had the most awesome time recording next week's #MattersMicrobial podcast session with Dr. Hannah Ledvina of the University of Michigan. Her work on the "shield" that E. coli can make against Bdellovibrio attack was amazing. Plus, we share many common enthusiasms. It was a proper nerdfest.
October 31, 2025 at 9:18 PM
I had the most awesome time recording next week's #MattersMicrobial podcast session with Dr. Hannah Ledvina of the University of Michigan. Her work on the "shield" that E. coli can make against Bdellovibrio attack was amazing. Plus, we share many common enthusiasms. It was a proper nerdfest.
Reposted by Anthony Vecchiarelli
LA Dodger’s Freddie Freedom speaks about his Canadian Mom.
He seems like a really nice guy, I hope his team comes in 2nd place.
#Canada
#TorontoBlueJays
#LADodgers
#WorldSeries
He seems like a really nice guy, I hope his team comes in 2nd place.
#Canada
#TorontoBlueJays
#LADodgers
#WorldSeries
October 25, 2025 at 1:12 PM
LA Dodger’s Freddie Freedom speaks about his Canadian Mom.
He seems like a really nice guy, I hope his team comes in 2nd place.
#Canada
#TorontoBlueJays
#LADodgers
#WorldSeries
He seems like a really nice guy, I hope his team comes in 2nd place.
#Canada
#TorontoBlueJays
#LADodgers
#WorldSeries