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Reposted by Anthony Vecchiarelli

Jeremy Berg @jeremymberg.bsky.social · 1d

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.

Deafening Quiet from the Scientific Establishment

jeremymberg.github.io/jeremyberg.g...

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jeremymberg.github.io

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Reposted by Anthony Vecchiarelli

Amelia Randich @ameliarandich.bsky.social · 7d

Interested in a tenure track position teaching and doing research with undergrads at a PUI? We are looking for a broadly-defined microbiologist who can teach Med Micro and Immunology. Apply at universityofscrantonjobs.com/postings/8308. Pls share widely to feeds (& on twitter if you still tweet)! 🦠

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Reposted by Anthony Vecchiarelli

Anthony Vecchiarelli @cellforganized.bsky.social · 15d

New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵

Collaboration with the Giessen and Pi labs

Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!

www.biorxiv.org/content/10.1...

Engineering Spatial Control of Bacterial Organelles

Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...

www.biorxiv.org

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Reposted by Anthony Vecchiarelli

Tung Le @tunglejic.bsky.social · 5d

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

John Innes Centre @johninnescentre.bsky.social · 5d

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...

Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre

The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…

www.jic.ac.uk

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Reposted by Anthony Vecchiarelli

Ryan Marino, MD @ryanmarino.bsky.social · 7d

This is why we fund scientists to study things like oyster slobber even if you don’t think it sounds important

Leah McElrath @leahmcelrath.bsky.social · 9d

⚠️ Chinese researchers have invented bone glue that mimics how oysters stick to surfaces underwater.

The adhesive can reportedly repair orthopedic fractures in 2-3 minutes, even in blood-rich environments, and is bioabsorbable.

interestingengineering.com/science/chin...

China's oyster-inspired 'bone glue' bonds fractures in minutes

A new oyster-inspired Bone-02 adhesive can revolutionize bone repair without metal fasteners.

interestingengineering.com

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Reposted by Anthony Vecchiarelli

Jutras Lab @jutraslab.bsky.social · 7d

Invited to give a talk by graduate students-who DRIVE research nationwide-is easily one of the greatest honors for a PI. It’s even better when one of your former mentees is the host! Thank you Tanner and @harvard.edu Micro for being a bright light in these dark times. 🙏 Science will prevail 💪

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Reposted by Anthony Vecchiarelli

The Robert Mehrabian College of Engineering @ucsbengineering.bsky.social · 7d

We kicked off the new school year with the launch of the BioFoundry for Extreme and Exceptional Fungi, Archaea and Bacteria (ExFAB). The new facility will allow researchers to make novel discoveries using previously unstudied microbes that could generate advances in biotechnology & biomanufacturing.

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Reposted by Anthony Vecchiarelli

Manuel Thery @manuelthery.bsky.social · 7d

THE Erwin Frey, talking about self-organization in biological systems. Title of the seminar serie suggests it might be intended for physicists.

APS DSNP @aps-dsnp.bsky.social · 8d

📌 Join us for the next klogW seminar on October 21st at 12PM EST (register below) by Erwin Frey @physicsoflifelmu.bsky.social on "Emergence and Self-organization in Biological Systems".
Registration link:
apsphysics.zoom.us/meeting/regi...

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Reposted by Anthony Vecchiarelli

Benoit Bruneau @benoitbruneau.bsky.social · 8d

thank you to all the NIH staff who stand by their duty and put in heroic efforts to get it done. I'll never forget it and will be eternally grateful.

Jeremy Berg @jeremymberg.bsky.social · 9d

The fiscal year ends tomorrow.

Here are results from NIH Reporter downloaded an hour ago.

The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.

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$A graph showing the fraction of annual grant funding committed for NIH for fiscal years 2015 to 2025. The fiscal year 2025 lagged behind but then caught up over the last two months.$

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Reposted by Anthony Vecchiarelli

Jeremy BOO! Yoder 🎃💀🕷️ @jbyoder.org · 8d

We've already got hundreds of students and mentors here, sharing how the sudden policy change has derailed plans. We're looking at formally "delivering" results to NSF leadership tomorrow, please do keep sharing and spreading the word: laurenkuehne.github.io/grfpChanges/

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Anthony Vecchiarelli @cellforganized.bsky.social · 9d

Congratulations Manuel! My lab and I already read the preprint several times, and I'm happy to see it published. It really inspired some of our upcoming work. Thank you!

Reposted by Anthony Vecchiarelli

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 11d

Unannotated translation products are widespread in model E. coli https://www.biorxiv.org/content/10.1101/2025.09.25.678689v1

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Anthony Vecchiarelli @cellforganized.bsky.social · 11d

❤️✊️

Reposted by Anthony Vecchiarelli

Emmanuele Severi @emmseveri.bsky.social · 11d

www.nature.com/articles/s41...

#microsky

Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation - Nature Communications

ParABS systems partition chromosomal DNA and low-copy plasmids in bacteria. Here, the authors elucidate the mode of interaction between ParA and ParB and clarify how ParB stimulates the ATPase activity of ParA to drive the segregation process.

www.nature.com

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Reposted by Anthony Vecchiarelli

Géraldine Laloux @lalouxlab.bsky.social · 13d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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Reposted by Anthony Vecchiarelli

Anthony Vecchiarelli @cellforganized.bsky.social · Aug 26

My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!

Applications Due by October 15, 2025

We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.

lsa.umich.edu/mcdb/news-ev...

MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB)

MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...

lsa.umich.edu

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Reposted by Anthony Vecchiarelli

Géraldine Laloux @lalouxlab.bsky.social · 21d

🚨New paper out! #MicroSky
Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival.
We expanded its genetic toolbox:
🧬promoters to fine-tune expression
🧬IPTG-inducible system
🧬CRISPRi for rapid knockdown
bit.ly/46GUn2c
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Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference

Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.

academic.oup.com

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Reposted by Anthony Vecchiarelli

Shyamal @shyamalm.bsky.social · 15d

Ever wondered how to position organelles in bacteria? Wonder no more!
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.

The avenues this opens in the synthetic biology space are enormous!

Movie: Carboxysomes positioned in E. coli!

Preprint: shorturl.at/D6xVg

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Anthony Vecchiarelli @cellforganized.bsky.social · 15d

The capacity to engineer both the composition of compartments and their positioning advances synthetic biology into a new era, where the spatial context of cellular function (“where”) can be programmed as readily as its content (“what”).

This was a massive team effort. Congrats to all authors!

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Anthony Vecchiarelli @cellforganized.bsky.social · 15d

By fusing this MapTag to heterologous organelles and co-expressing McdA, we reprogramed the distribution of condensates, encapsulins, and even membrane-bound organelles in E. coli!

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Anthony Vecchiarelli @cellforganized.bsky.social · 15d

We then repurposed McdAB as a generalized spatial regulator for other bacterial organelles. An N-terminal peptide of McdB is necessary and sufficient for McdA interaction. We developed this McdB peptide into a minimal autonomous positioning tag or “MapTag”.

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Anthony Vecchiarelli @cellforganized.bsky.social · 15d

We also observed carboxysome “partitioning,” where the shell appears to invaginate at the midpoint of a larger carboxysome, suggesting that McdAB may play a role in carboxysome size regulation by subdividing oversized structures.

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Anthony Vecchiarelli @cellforganized.bsky.social · 15d

Without McdAB, CryoET shows large and disorganized aggregates of carboxysome components at the cell poles. By contrast, McdAB-expressing cells displayed fully assembled, properly sized, and unclustered carboxysomes distributed across the nucleoid region of the cell!

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Anthony Vecchiarelli @cellforganized.bsky.social · 15d

First, we showed that McdAB can distribute carboxysomes in E. coli!

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Anthony Vecchiarelli @cellforganized.bsky.social · 15d

McdAB is currently the only known minimal and self-organizing positioning system for any protein-based organelle in bacteria. Could McdAB be repurposed to provide synthetic spatial control in (1) other bacteria and (2) other organelle types?

a man in a suit and tie has the word question written on his chest

ALT: a man in a suit and tie has the word question written on his chest

media.tenor.com

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