Tiago J. Costa
@tiagojcosta.bsky.social
Associate Professor at USP
Pharmacologist
Connecting the universe of sex hormones and vascular biology
Running enthusiasts
Twitter: tiagojcosta_
Pharmacologist
Connecting the universe of sex hormones and vascular biology
Running enthusiasts
Twitter: tiagojcosta_
Please join us for the next
@vascularbiology #Symposium!!!
Thursday, March 27 @ 1 pm ET!
👉 Register at tinyurl.com/2azhpxa7
@vascularbiology #Symposium!!!
Thursday, March 27 @ 1 pm ET!
👉 Register at tinyurl.com/2azhpxa7
March 20, 2025 at 10:57 PM
Please join us for the next
@vascularbiology #Symposium!!!
Thursday, March 27 @ 1 pm ET!
👉 Register at tinyurl.com/2azhpxa7
@vascularbiology #Symposium!!!
Thursday, March 27 @ 1 pm ET!
👉 Register at tinyurl.com/2azhpxa7
🚀 USP Academy 2025 has begun!
Join us as we discuss arterial hypertension with experts from universities worldwide. 🌍💡
#Hypertension #USPAcademy2025
Join us as we discuss arterial hypertension with experts from universities worldwide. 🌍💡
#Hypertension #USPAcademy2025
February 17, 2025 at 1:22 PM
🚀 USP Academy 2025 has begun!
Join us as we discuss arterial hypertension with experts from universities worldwide. 🌍💡
#Hypertension #USPAcademy2025
Join us as we discuss arterial hypertension with experts from universities worldwide. 🌍💡
#Hypertension #USPAcademy2025
Reposted by Tiago J. Costa
Glomerular Neovascularization
#DiabeticKidneyDisease #CaseReport
#SpatialTranscriptomics #Visium @10xGenomics
50-μm section multiplex IF
TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule
#KPMProject #CJASN 2024
journals.lww.com/cjasn/abstra...
#DiabeticKidneyDisease #CaseReport
#SpatialTranscriptomics #Visium @10xGenomics
50-μm section multiplex IF
TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule
#KPMProject #CJASN 2024
journals.lww.com/cjasn/abstra...
February 5, 2025 at 12:49 PM
Glomerular Neovascularization
#DiabeticKidneyDisease #CaseReport
#SpatialTranscriptomics #Visium @10xGenomics
50-μm section multiplex IF
TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule
#KPMProject #CJASN 2024
journals.lww.com/cjasn/abstra...
#DiabeticKidneyDisease #CaseReport
#SpatialTranscriptomics #Visium @10xGenomics
50-μm section multiplex IF
TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule
#KPMProject #CJASN 2024
journals.lww.com/cjasn/abstra...
Reposted by Tiago J. Costa
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 24, 2025 at 4:30 AM
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Reposted by Tiago J. Costa
Thanks for highlighting this work. Serendipitously, Luc - a visiting student - made the first surprising observation!
👏 Quite proud of Emily @xinruilimemily1.bsky.social and Luc! 👏
👏 Quite proud of Emily @xinruilimemily1.bsky.social and Luc! 👏
Amyloidβ Aβ1-40 activates #Piezo1 channels in brain capillary #EndothelialCell via ROS
Another splendid patch-clamp study from @osamaharraz.bsky.social
Aβ1-40 doesn't have to be in the pipette to activate Piezo1, likely an indirect effect
@biophysj.bsky.social 2024
www.cell.com/biophysj/abs...
Another splendid patch-clamp study from @osamaharraz.bsky.social
Aβ1-40 doesn't have to be in the pipette to activate Piezo1, likely an indirect effect
@biophysj.bsky.social 2024
www.cell.com/biophysj/abs...
January 12, 2025 at 1:53 PM
Thanks for highlighting this work. Serendipitously, Luc - a visiting student - made the first surprising observation!
👏 Quite proud of Emily @xinruilimemily1.bsky.social and Luc! 👏
👏 Quite proud of Emily @xinruilimemily1.bsky.social and Luc! 👏
Reposted by Tiago J. Costa
#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
December 25, 2024 at 11:53 AM
#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
Reposted by Tiago J. Costa
#MetaplasticBreastCancer
SEER database 2010-2014
1112 MpBC
21321 Tri-neg #BreastCancer
21~24 mo f/up
Chemotherapy-> No benefit
Radiotherapy-> HR=1.5
Compromised survivals of TN vs non-TN MpBC
Breast Cancer Res Treat 2018
link.springer.com/article/10.1...
SEER database 2010-2014
1112 MpBC
21321 Tri-neg #BreastCancer
21~24 mo f/up
Chemotherapy-> No benefit
Radiotherapy-> HR=1.5
Compromised survivals of TN vs non-TN MpBC
Breast Cancer Res Treat 2018
link.springer.com/article/10.1...
December 8, 2024 at 9:38 PM
#MetaplasticBreastCancer
SEER database 2010-2014
1112 MpBC
21321 Tri-neg #BreastCancer
21~24 mo f/up
Chemotherapy-> No benefit
Radiotherapy-> HR=1.5
Compromised survivals of TN vs non-TN MpBC
Breast Cancer Res Treat 2018
link.springer.com/article/10.1...
SEER database 2010-2014
1112 MpBC
21321 Tri-neg #BreastCancer
21~24 mo f/up
Chemotherapy-> No benefit
Radiotherapy-> HR=1.5
Compromised survivals of TN vs non-TN MpBC
Breast Cancer Res Treat 2018
link.springer.com/article/10.1...
Reposted by Tiago J. Costa
Development of the nervous system in a #zebrafish larva. Credit to Dr. Nathan Martin of @plavickilab.bsky.social. #ZebrafishZunday 🧪
December 8, 2024 at 10:54 AM
Development of the nervous system in a #zebrafish larva. Credit to Dr. Nathan Martin of @plavickilab.bsky.social. #ZebrafishZunday 🧪
Reposted by Tiago J. Costa
Our editorial for this fantastic paper -
www.ahajournals.org/doi/10.1161/...
published in @CircRes @ahajournals.bsky.social is now in pubmed 👇
pubmed.ncbi.nlm.nih.gov/39636968/
www.ahajournals.org/doi/10.1161/...
published in @CircRes @ahajournals.bsky.social is now in pubmed 👇
pubmed.ncbi.nlm.nih.gov/39636968/
December 9, 2024 at 9:30 PM
Our editorial for this fantastic paper -
www.ahajournals.org/doi/10.1161/...
published in @CircRes @ahajournals.bsky.social is now in pubmed 👇
pubmed.ncbi.nlm.nih.gov/39636968/
www.ahajournals.org/doi/10.1161/...
published in @CircRes @ahajournals.bsky.social is now in pubmed 👇
pubmed.ncbi.nlm.nih.gov/39636968/