Tom Mathers
@tom-mathers.bsky.social
230 followers 350 following 27 posts
Evolutionary biologist. Genomics, aphids and gardening. Senior Computer Biologist at Wellcome Sanger Institute.
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tom-mathers.bsky.social
Struggling to find the tiny microchromosomes in draft bird genome assemblies?

Our new #preprint introducing MicroFinder can help: www.biorxiv.org/content/10.1...

🧵 below

(1/n)

@sangerinstitute.bsky.social
tom-mathers.bsky.social
Second cut of the year for the rosemary hedge. The most fragrant job in the garden!
Reposted by Tom Mathers
marcelauliano.bsky.social
Now out! Paper led by @philmor1964.bsky.social and the The Cetacean Genomes Project. An effort by many, we present 13 new, high-quality reference genomes for cetaceans 🐬🐋 following @vertebrategenomes.bsky.social and @ebpgenome.bsky.social standards for a group that is very hard to sample from.
tom-mathers.bsky.social
😱 Simultaneously curating all 8 haplotypes of octaploid Carpinus betulus (European hornbeam).

One set of chromosomes down, many more to go...

@sangerinstitute.bsky.social Darwin Tree of Life.
tom-mathers.bsky.social
Great to see this out. Hopefully very useful assemblies for the community.

These were very challenging to assemble due to high heterozygosity and lots of recent repeat activity. Tom Heaven put in a huge effort with manual #HiC #curation to get them in good shape.
Reposted by Tom Mathers
genomebiolevol.bsky.social
Heaven @saskiahogenhout.bsky.social et al. generated chromosome-level genomes for three psyllid species that are plant disease vectors, revealing detoxification gene expansions and genetic substructure across Europe.

🔗 doi.org/10.1093/gbe/evaf116

#genome #entomology
tom-mathers.bsky.social
Helenium Moerheim Beauty doing well in the dry conditions.
Reposted by Tom Mathers
joanameier.bsky.social
Join us on the Wellcome Genome Campus of the Sanger Institute and EBI for a symposium on biodiversity genomics from 27th-29th October! Abstract deadline on 14 July. There is also an option to join via Zoom, but in-person is much nicer if you can make it.
eventswcs.bsky.social
Present your insights from studies into #eukaryotic genomes at our #Biodiversity25 conference! 📈

🗓️ 27-29 October 2025
Submit by 14 July 📩

We encourage submissions showcasing best practices for applying new methods and resources to analyse #biodiversity genomes at scale 🌳🧬

📎 bit.ly/4j3vAZ9
Wellcome Connecting Science hybrid conference
Understanding Life: Using Large-scale Biodiversity Reference Genomes 

Conference dates: 27-29 October 2025
Location: Hinxton Hall Conference Centre, Wellcome Genome Campus, UK and online

Bursary and abstract deadline: 14 July 
Registration deadlines
In person: 29 September 
Virtual: 20 October
tom-mathers.bsky.social
First group three clematis flowers. Early this year due to the hot spring.
tom-mathers.bsky.social
Shropshire lad, grown from a cutting.
Reposted by Tom Mathers
mcmullan0.bsky.social
Thanks for posting @reviewcommons.org

If you're interested you can also find the reviewed version here:
doi.org/10.7554/eLif...

Really keen to get people's perspectives on the population genetics of reservoirs, and what they tell us about variation associated with emergent crop pathogens.
Reposted by Tom Mathers
Reposted by Tom Mathers
rowenahill.bsky.social
Our paper on phylogenetics of fungal Starship TEs is now on the cover of the June issue of Genetics @genetics-gsa.bsky.social 🙂
academic.oup.com/genetics/iss...

@mcmullan0.bsky.social @earlhaminst.bsky.social @rothamsted.bsky.social
Cover for the June issue of the journal Genetics, with an abstract illustration in the background showing starships flying through space trailing DNA sequences that meet in the bottom right corner to form a circular phylogenetic tree
Reposted by Tom Mathers
jsantoyo.bsky.social
Starship giant transposable elements cluster by host taxonomy using k-mer-based phylogenetics. #TransposableElements #TEs #Kmer #Phylogenetics #Genomics #Bioinformatics #G3 🧬 🖥️
academic.oup.com/g3journal/ad...
Reposted by Tom Mathers
nancy-moran.bsky.social
An update on open postdoc positions, in my group and the adjacent group of Howard Ochman, here at UT-Austin. #SymbioSky

Mine: insect-bacterial symbiosis with emphasis on intracellular endosymbionts and molecular mechanisms.
web.biosci.utexas.edu/moran/contac...
Nancy Moran Contact
web.biosci.utexas.edu
Reposted by Tom Mathers
dongwookkim.bsky.social
Unicore is now published on GBE 🚀
Unicore rapidly identifies structural single-copy core genes from input species proteomes for phylogenetic analysis. Powered by Foldseek and ProstT5, Unicore enables linear-scale structure-based phylogeny of any given set of taxa. 🧵1/n
📃 doi.org/10.1093/gbe/evaf109
tom-mathers.bsky.social
Rosa Charles de Mills with Geum Totally Tangerine.
tom-mathers.bsky.social
Thanks!

The gene set in the current version is tailored for birds but no reason why this approach couldn’t help with other species using a custom gene set. We started with birds as there had been a long-standing problem finding all the micros.
Reposted by Tom Mathers
kamilsjaron.bsky.social
Interested to read a perspective by >160 reproductive biologists? The new Tree of Sex white paper is out! Led by
@danjeffries.bsky.social 👏